# Investigating the Role of Bilateral Symmetry for Inpainting Brain MRI

arXiv: https://arxiv.org/abs/2504.10039 · HTML: https://mlsanity.com/paper/2504.10039/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 16 of its 25 references that are in the map.
- First posted on arXiv 14 Apr 2025.

## Builds on (most cited first, 16 of 16)

- [Denoising Diffusion Probabilistic Models](https://mlsanity.com/paper/2006.11239/) (2020)
- [Diffusion Models Beat GANs on Image Synthesis](https://mlsanity.com/paper/2105.05233/) (2021)
- [Hierarchical Text-Conditional Image Generation with CLIP Latents](https://mlsanity.com/paper/2204.06125/) (2022)
- [Photorealistic Text-to-Image Diffusion Models with Deep Language Understanding](https://mlsanity.com/paper/2205.11487/) (2022)
- [SGDR: Stochastic Gradient Descent with Warm Restarts](https://mlsanity.com/paper/1608.03983/) (2016)
- [Neural Discrete Representation Learning](https://mlsanity.com/paper/1711.00937/) (2017)
- [Improved Techniques for Training GANs](https://mlsanity.com/paper/1606.03498/) (2016)
- [RePaint: Inpainting using Denoising Diffusion Probabilistic Models](https://mlsanity.com/paper/2201.09865/) (2022)
- [Context Encoders: Feature Learning by Inpainting](https://mlsanity.com/paper/1604.07379/) (2016)
- [Free-Form Image Inpainting with Gated Convolution](https://mlsanity.com/paper/1806.03589/) (2018)
- [Image Inpainting for Irregular Holes Using Partial Convolutions](https://mlsanity.com/paper/1804.07723/) (2018)
- [Pluralistic Image Completion](https://mlsanity.com/paper/1903.04227/) (2019)
- [Generating Diverse Structure for Image Inpainting With Hierarchical VQ-VAE](https://mlsanity.com/paper/2103.10022/) (2021)
- [Unsupervised 3D out-of-distribution detection with latent diffusion models](https://mlsanity.com/paper/2307.03777/) (2023)
- [Reversing the Abnormal: Pseudo-Healthy Generative Networks for Anomaly Detection](https://mlsanity.com/paper/2303.08452/) (2023)
- [Adversarial Inpainting of Medical Image Modalities](https://mlsanity.com/paper/1810.06621/) (2018)

## Abstract (arXiv)

Inpainting has recently emerged as a valuable and interesting technology to employ in the analysis of medical imaging data, in particular brain MRI. A wide variety of methodologies for inpainting MRI have been proposed and demonstrated on tasks including anomaly detection. In this work we investigate the statistical relationship between inpainted brain structures and the amount of subject-specific conditioning information, i.e. the other areas of the image that are masked. In particular, we analyse the distribution of inpainting results when masking additional regions of the image, specifically the contra-lateral structure. This allows us to elucidate where in the brain the model is drawing information from, and in particular, what is the importance of hemispherical symmetry? Our experiments interrogate a diffusion inpainting model through analysing the inpainting of subcortical brain structures based on intensity and estimated area change. We demonstrate that some structures show a strong influence of symmetry in the conditioning of the inpainting process.