# The AI Scientist-v2: Workshop-Level Automated Scientific Discovery via Agentic Tree Search

arXiv: https://arxiv.org/abs/2504.08066 · HTML: https://mlsanity.com/paper/2504.08066/

## Key facts

- Cited by 422 papers in the map (data through 14 Oct 2026).
- Placed in Web, search, and research agents, one of 16 directions in LLM agents and tool use.
- Builds on 10 of its 31 references that are in the map.
- First posted on arXiv 10 Apr 2025.

## Placed in

- LLM agents and tool use / [Web, search, and research agents](https://mlsanity.com/agents/web-search-and-research-agents/)

## Builds on (most cited first, 10 of 10)

- [The AI Scientist: Towards Fully Automated Open-Ended Scientific Discovery](https://mlsanity.com/paper/2408.06292/) (2024)
- [Agent Laboratory: Using LLM Agents as Research Assistants](https://mlsanity.com/paper/2501.04227/) (2025)
- [Accelerating scientific discovery with Co-Scientist](https://mlsanity.com/paper/2502.18864/) (2025)
- [AIDE: AI-Driven Exploration in the Space of Code](https://mlsanity.com/paper/2502.13138/) (2025)
- [BixBench: a Comprehensive Benchmark for LLM-based Agents in Computational Biology](https://mlsanity.com/paper/2503.00096/) (2025)
- [AI-GAs: AI-generating algorithms, an alternate paradigm for producing general artificial intelligence](https://mlsanity.com/paper/1905.10985/) (2019)
- [Superintelligent Agents Pose Catastrophic Risks: Can Scientist AI Offer a Safer Path?](https://mlsanity.com/paper/2502.15657/) (2025)
- [AgentRxiv: Towards Collaborative Autonomous Research](https://mlsanity.com/paper/2503.18102/) (2025)
- [Transforming Science with Large Language Models: A Survey on AI-assisted Scientific Discovery, Experimentation, Content Generation, and Evaluation](https://mlsanity.com/paper/2502.05151/) (2025)
- [Evaluating Sakana's AI Scientist: Bold Claims, Mixed Results, and a Promising Future?](https://mlsanity.com/paper/2502.14297/) (2025)

## Built on by (most cited first, 30 of 422)

- [Self-Harness: Harnesses That Improve Themselves](https://mlsanity.com/paper/2606.09498/) (2026)
- [AI-Researcher: Autonomous Scientific Innovation](https://mlsanity.com/paper/2505.18705/) (2025)
- [From Automation to Autonomy: A Survey on Large Language Models in Scientific Discovery](https://mlsanity.com/paper/2505.13259/) (2025)
- [Perception, Reason, Think, and Plan: A Survey on Large Multimodal Reasoning Models](https://mlsanity.com/paper/2505.04921/) (2025)
- [A Self-Improving Coding Agent](https://mlsanity.com/paper/2504.15228/) (2025)
- [From AI for Science to Agentic Science: A Survey on Autonomous Scientific Discovery](https://mlsanity.com/paper/2508.14111/) (2025)
- [AI Research Agents for Machine Learning: Search, Exploration, and Generalization in MLE-bench](https://mlsanity.com/paper/2507.02554/) (2025)
- [Paper2Code: Automating Code Generation from Scientific Papers in Machine Learning](https://mlsanity.com/paper/2504.17192/) (2025)
- [Deep Research: A Survey of Autonomous Research Agents](https://mlsanity.com/paper/2508.12752/) (2025)
- [MLR-Bench: Evaluating AI Agents on Open-Ended Machine Learning Research](https://mlsanity.com/paper/2505.19955/) (2025)
- [DeepScientist: Advancing Frontier-Pushing Scientific Findings Progressively](https://mlsanity.com/paper/2509.26603/) (2025)
- [TRiSM for Agentic AI: A Review of Trust, Risk, and Security Management in LLM-based Agentic Multi-Agent Systems](https://mlsanity.com/paper/2506.04133/) (2025)
- [Towards Robust Agentic CUDA Kernel Benchmarking, Verification, and Optimization](https://mlsanity.com/paper/2509.14279/) (2025)
- [A Survey of Agentic Reasoning for Large Language Models: Towards Recursively Self-Improving and Collective Agents](https://mlsanity.com/paper/2601.12538/) (2026)
- [Code as Agent Harness](https://mlsanity.com/paper/2605.18747/) (2026)
- [ReportBench: Evaluating Deep Research Agents via Academic Survey Tasks](https://mlsanity.com/paper/2508.15804/) (2025)
- [AIRS-Bench: a Suite of Tasks for Frontier AI Research Science Agents](https://mlsanity.com/paper/2602.06855/) (2026)
- [ENPIRE: Agentic Robot Policy Self-Improvement in the Real World](https://mlsanity.com/paper/2606.19980/) (2026)
- [A Survey of Scientific Large Language Models: From Data Foundations to Agent Frontiers](https://mlsanity.com/paper/2508.21148/) (2025)
- [NewtonBench: Benchmarking Generalizable Scientific Law Discovery in LLM Agents](https://mlsanity.com/paper/2510.07172/) (2025)
- [Ax-Prover: A Deep Reasoning Agentic Framework for Theorem Proving in Mathematics and Quantum Physics](https://mlsanity.com/paper/2510.12787/) (2025)
- [The 2025 AI Agent Index: Documenting Technical and Safety Features of Deployed Agentic AI Systems](https://mlsanity.com/paper/2602.17753/) (2026)
- [MLRC-Bench: Can Language Agents Solve Machine Learning Research Challenges?](https://mlsanity.com/paper/2504.09702/) (2025)
- [PiFlow: Principle-Aware Scientific Discovery with Multi-Agent Collaboration](https://mlsanity.com/paper/2505.15047/) (2025)
- [Towards Execution-Grounded Automated AI Research](https://mlsanity.com/paper/2601.14525/) (2026)
- [InternAgent-1.5: A Unified Agentic Framework for Long-Horizon Autonomous Scientific Discovery](https://mlsanity.com/paper/2602.08990/) (2026)
- [MM-Agent: LLM as Agents for Real-world Mathematical Modeling Problem](https://mlsanity.com/paper/2505.14148/) (2025)
- [MARS: Modular Agent with Reflective Search for Automated AI Research](https://mlsanity.com/paper/2602.02660/) (2026)
- [AutoResearchClaw: Self-Reinforcing Autonomous Research with Human-AI Collaboration](https://mlsanity.com/paper/2605.20025/) (2026)
- [AutoFigure: Generating and Refining Publication-Ready Scientific Illustrations](https://mlsanity.com/paper/2602.03828/) (2026)

## Abstract (arXiv)

AI is increasingly playing a pivotal role in transforming how scientific discoveries are made. We introduce The AI Scientist-v2, an end-to-end agentic system capable of producing the first entirely AI generated peer-review-accepted workshop paper. This system iteratively formulates scientific hypotheses, designs and executes experiments, analyzes and visualizes data, and autonomously authors scientific manuscripts. Compared to its predecessor (v1, Lu et al., 2024 arXiv:2408.06292), The AI Scientist-v2 eliminates the reliance on human-authored code templates, generalizes effectively across diverse machine learning domains, and leverages a novel progressive agentic tree-search methodology managed by a dedicated experiment manager agent. Additionally, we enhance the AI reviewer component by integrating a Vision-Language Model (VLM) feedback loop for iterative refinement of content and aesthetics of the figures. We evaluated The AI Scientist-v2 by submitting three fully autonomous manuscripts to a peer-reviewed ICLR workshop. Notably, one manuscript achieved high enough scores to exceed the average human acceptance threshold, marking the first instance of a fully AI-generated paper successfully navigating a peer review. This accomplishment highlights the growing capability of AI in conducting all aspects of scientific research. We anticipate that further advancements in autonomous scientific discovery technologies will profoundly impact human knowledge generation, enabling unprecedented scalability in research productivity and significantly accelerating scientific breakthroughs, greatly benefiting society at large. We have open-sourced the code at https://github.com/SakanaAI/AI-Scientist-v2 to foster the future development of this transformative technology. We also discuss the role of AI in science, including AI safety.