# STeP: A Framework for Solving Scientific Video Inverse Problems with Spatiotemporal Diffusion Priors

arXiv: https://arxiv.org/abs/2504.07549 · HTML: https://mlsanity.com/paper/2504.07549/

## Key facts

- Cited by 3 papers in the map (data through 14 Oct 2026).
- Placed in Inverse problems and image restoration, one of 14 directions in Diffusion models.
- Builds on 49 of its 75 references that are in the map.
- First posted on arXiv 10 Apr 2025.

## Placed in

- Diffusion models / [Inverse problems and image restoration](https://mlsanity.com/diffusion/inverse-problems-and-image-restoration/)

## Builds on (most cited first, 30 of 49)

- [Denoising Diffusion Probabilistic Models](https://mlsanity.com/paper/2006.11239/) (2020)
- [High-Resolution Image Synthesis with Latent Diffusion Models](https://mlsanity.com/paper/2112.10752/) (2021)
- [The Unreasonable Effectiveness of Deep Features as a Perceptual Metric](https://mlsanity.com/paper/1801.03924/) (2018)
- [Score-Based Generative Modeling through Stochastic Differential Equations](https://mlsanity.com/paper/2011.13456/) (2020)
- [Neural Discrete Representation Learning](https://mlsanity.com/paper/1711.00937/) (2017)
- [Generative Modeling by Estimating Gradients of the Data Distribution](https://mlsanity.com/paper/1907.05600/) (2019)
- [Taming Transformers for High-Resolution Image Synthesis](https://mlsanity.com/paper/2012.09841/) (2020)
- [Elucidating the Design Space of Diffusion-Based Generative Models](https://mlsanity.com/paper/2206.00364/) (2022)
- [Stable Video Diffusion: Scaling Latent Video Diffusion Models to Large Datasets](https://mlsanity.com/paper/2311.15127/) (2023)
- [RAFT: Recurrent All-Pairs Field Transforms for Optical Flow](https://mlsanity.com/paper/2003.12039/) (2020)
- [Image Super-Resolution via Iterative Refinement](https://mlsanity.com/paper/2104.07636/) (2021)
- [Align your Latents: High-Resolution Video Synthesis with Latent Diffusion Models](https://mlsanity.com/paper/2304.08818/) (2023)
- [Diffusion Posterior Sampling for General Noisy Inverse Problems](https://mlsanity.com/paper/2209.14687/) (2022)
- [Towards Accurate Generative Models of Video: A New Metric & Challenges](https://mlsanity.com/paper/1812.01717/) (2018)
- [Denoising Diffusion Restoration Models](https://mlsanity.com/paper/2201.11793/) (2022)
- [Tune-A-Video: One-Shot Tuning of Image Diffusion Models for Text-to-Video Generation](https://mlsanity.com/paper/2212.11565/) (2022)
- [Zero-Shot Image Restoration Using Denoising Diffusion Null-Space Model](https://mlsanity.com/paper/2212.00490/) (2022)
- [Solving Inverse Problems in Medical Imaging with Score-Based Generative Models](https://mlsanity.com/paper/2111.08005/) (2021)
- [Denoising Diffusion Models for Plug-and-Play Image Restoration](https://mlsanity.com/paper/2305.08995/) (2023)
- [Understanding disentangling in β-VAE](https://mlsanity.com/paper/1804.03599/) (2018)
- [Score-based diffusion models for accelerated MRI](https://mlsanity.com/paper/2110.05243/) (2021)
- [Robust Compressed Sensing MRI with Deep Generative Priors](https://mlsanity.com/paper/2108.01368/) (2021)
- [Diffusion probabilistic modeling of protein backbones in 3D for the motif-scaffolding problem](https://mlsanity.com/paper/2206.04119/) (2022)
- [Practical and Asymptotically Exact Conditional Sampling in Diffusion Models](https://mlsanity.com/paper/2306.17775/) (2023)
- [A Variational Perspective on Solving Inverse Problems with Diffusion Models](https://mlsanity.com/paper/2305.04391/) (2023)
- [Solving Inverse Problems with Latent Diffusion Models via Hard Data Consistency](https://mlsanity.com/paper/2307.08123/) (2023)
- [Improving Diffusion Inverse Problem Solving with Decoupled Noise Annealing](https://mlsanity.com/paper/2407.01521/) (2024)
- [Solving Linear Inverse Problems Provably via Posterior Sampling with Latent Diffusion Models](https://mlsanity.com/paper/2307.00619/) (2023)
- [Score-Based Diffusion Models as Principled Priors for Inverse Imaging](https://mlsanity.com/paper/2304.11751/) (2023)
- [Principled Probabilistic Imaging using Diffusion Models as Plug-and-Play Priors](https://mlsanity.com/paper/2405.18782/) (2024)

## Built on by (most cited first, 3 of 3)

- [Solving Inverse Problems via Diffusion-Based Priors: An Approximation-Free Ensemble Sampling Approach](https://mlsanity.com/paper/2506.03979/) (2025)
- [MIRA: A Score for Conditional Distribution Accuracy and Model Comparison](https://mlsanity.com/paper/2605.02014/) (2026)
- [Multimodal Spatiotemporal Atmospheric Data Assimilation with Latent Video Flow-matching](https://mlsanity.com/paper/2608.05103/) (2026)

## Abstract (arXiv)

Reconstructing spatially and temporally coherent videos from time-varying measurements is a fundamental challenge in many scientific domains. A major difficulty arises from the sparsity of measurements, which hinders accurate recovery of temporal dynamics. Existing image diffusion-based methods rely on extracting temporal consistency directly from measurements, limiting their effectiveness on scientific tasks with high spatiotemporal uncertainty. We address this difficulty by proposing a plug-and-play framework that incorporates a learned spatiotemporal diffusion prior. Due to its plug-and-play nature, our framework can be flexibly applied to different video inverse problems without the need for task-specific design and temporal heuristics. We further demonstrate that a spatiotemporal diffusion model can be trained efficiently with limited video data. We validate our approach on two challenging scientific video reconstruction tasks: black hole video reconstruction and dynamic MRI. While baseline methods struggle to provide temporally coherent reconstructions, our approach achieves significantly improved recovery of the spatiotemporal structure of the underlying ground truth videos.