# Identifying regions of interest in whole slide images of renal cell carcinoma

arXiv: https://arxiv.org/abs/2504.07313 · HTML: https://mlsanity.com/paper/2504.07313/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 8 of its 65 references that are in the map.
- First posted on arXiv 9 Apr 2025.

## Builds on (most cited first, 8 of 8)

- [Deep Residual Learning for Image Recognition](https://mlsanity.com/paper/1512.03385/) (2015)
- [Very Deep Convolutional Networks for Large-Scale Image Recognition](https://mlsanity.com/paper/1409.1556/) (2014)
- [Deep neural network models for computational histopathology: A survey](https://mlsanity.com/paper/1912.12378/) (2019)
- [Federated Learning for Computational Pathology on Gigapixel Whole Slide Images](https://mlsanity.com/paper/2009.10190/) (2020)
- [Fine-Tuning and Training of DenseNet for Histopathology Image Representation Using TCGA Diagnostic Slides](https://mlsanity.com/paper/2101.07903/) (2021)
- [Deep Learning for Whole Slide Image Analysis: An Overview](https://mlsanity.com/paper/1910.11097/) (2019)
- [Automated Classification of Histopathology Images Using Transfer Learning](https://mlsanity.com/paper/1903.10035/) (2019)
- [How Much Off-The-Shelf Knowledge Is Transferable From Natural Images To Pathology Images?](https://mlsanity.com/paper/2005.01609/) (2020)

## Abstract (arXiv)

The histopathological images contain a huge amount of information, which can make diagnosis an extremely timeconsuming and tedious task. In this study, we developed a completely automated system to detect regions of interest (ROIs) in whole slide images (WSI) of renal cell carcinoma (RCC), to reduce time analysis and assist pathologists in making more accurate decisions. The proposed approach is based on an efficient texture descriptor named dominant rotated local binary pattern (DRLBP) and color transformation to reveal and exploit the immense texture variability at the microscopic high magnifications level. Thereby, the DRLBPs retain the structural information and utilize the magnitude values in a local neighborhood for more discriminative power. For the classification of the relevant ROIs, feature extraction of WSIs patches was performed on the color channels separately to form the histograms. Next, we used the most frequently occurring patterns as a feature selection step to discard non-informative features. The performances of different classifiers on a set of 1800 kidney cancer patches originating from 12 whole slide images were compared and evaluated. Furthermore, the small size of the image dataset allows to investigate deep learning approach based on transfer learning for image patches classification by using deep features and fine-tuning methods. High recognition accuracy was obtained and the classifiers are efficient, the best precision result was 99.17% achieved with SVM. Moreover, transfer learning models perform well with comparable performance, and the highest precision using ResNet-50 reached 98.50%. The proposed approach results revealed a very efficient image classification and demonstrated efficacy in identifying ROIs. This study presents an automatic system to detect regions of interest relevant to the diagnosis of kidney cancer in whole slide histopathology images.