# Federated Learning for Medical Image Classification: A Comprehensive Benchmark

arXiv: https://arxiv.org/abs/2504.05238 · HTML: https://mlsanity.com/paper/2504.05238/

## Key facts

- Cited by 6 papers in the map (data through 14 Oct 2026).
- Builds on 55 of its 81 references that are in the map.
- First posted on arXiv 7 Apr 2025.

## Builds on (most cited first, 30 of 55)

- [Deep Residual Learning for Image Recognition](https://mlsanity.com/paper/1512.03385/) (2015)
- [Denoising Diffusion Probabilistic Models](https://mlsanity.com/paper/2006.11239/) (2020)
- [U-Net: Convolutional Networks for Biomedical Image Segmentation](https://mlsanity.com/paper/1505.04597/) (2015)
- [High-Resolution Image Synthesis with Latent Diffusion Models](https://mlsanity.com/paper/2112.10752/) (2021)
- [Communication-Efficient Learning of Deep Networks from Decentralized Data](https://mlsanity.com/paper/1602.05629/) (2016)
- [Rethinking the Inception Architecture for Computer Vision](https://mlsanity.com/paper/1512.00567/) (2015)
- [Deep Learning Face Attributes in the Wild](https://mlsanity.com/paper/1411.7766/) (2014)
- [Advances and Open Problems in Federated Learning](https://mlsanity.com/paper/1912.04977/) (2019)
- [Federated Optimization in Heterogeneous Networks](https://mlsanity.com/paper/1812.06127/) (2018)
- [On the Convergence of FedAvg on Non-IID Data](https://mlsanity.com/paper/1907.02189/) (2019)
- [When Does Label Smoothing Help?](https://mlsanity.com/paper/1906.02629/) (2019)
- [Tackling the Objective Inconsistency Problem in Heterogeneous Federated Optimization](https://mlsanity.com/paper/2007.07481/) (2020)
- [LEAF: A Benchmark for Federated Settings](https://mlsanity.com/paper/1812.01097/) (2018)
- [Model-Contrastive Federated Learning](https://mlsanity.com/paper/2103.16257/) (2021)
- [Ensemble Distillation for Robust Model Fusion in Federated Learning](https://mlsanity.com/paper/2006.07242/) (2020)
- [Ditto: Fair and Robust Federated Learning Through Personalization](https://mlsanity.com/paper/2012.04221/) (2020)
- [Local SGD Converges Fast and Communicates Little](https://mlsanity.com/paper/1805.09767/) (2018)
- [FedBN: Federated Learning on Non-IID Features via Local Batch Normalization](https://mlsanity.com/paper/2102.07623/) (2021)
- [Federated Learning Based on Dynamic Regularization](https://mlsanity.com/paper/2111.04263/) (2021)
- [Skin Lesion Analysis Toward Melanoma Detection: A Challenge at the 2017 International Symposium on Biomedical Imaging (ISBI), Hosted by the International Skin Imaging Collaboration (ISIC)](https://mlsanity.com/paper/1710.05006/) (2017)
- [Exploiting Shared Representations for Personalized Federated Learning](https://mlsanity.com/paper/2102.07078/) (2021)
- [FedMD: Heterogenous Federated Learning via Model Distillation](https://mlsanity.com/paper/1910.03581/) (2019)
- [Flower: A Friendly Federated Learning Research Framework](https://mlsanity.com/paper/2007.14390/) (2020)
- [FedML: A Research Library and Benchmark for Federated Machine Learning](https://mlsanity.com/paper/2007.13518/) (2020)
- [COVID-Net: A Tailored Deep Convolutional Neural Network Design for Detection of COVID-19 Cases from Chest X-Ray Images](https://mlsanity.com/paper/2003.09871/) (2020)
- [Don't Use Large Mini-Batches, Use Local SGD](https://mlsanity.com/paper/1808.07217/) (2018)
- [Federated Multi-Task Learning under a Mixture of Distributions](https://mlsanity.com/paper/2108.10252/) (2021)
- [FedKD: Communication Efficient Federated Learning via Knowledge Distillation](https://mlsanity.com/paper/2108.13323/) (2021)
- [FedBABU: Towards Enhanced Representation for Federated Image Classification](https://mlsanity.com/paper/2106.06042/) (2021)
- [FedDC: Federated Learning with Non-IID Data via Local Drift Decoupling and Correction](https://mlsanity.com/paper/2203.11751/) (2022)

## Built on by (most cited first, 6 of 6)

- [LCMem: A Universal Model for Robust Image Memorization Detection](https://mlsanity.com/paper/2512.14421/) (2025)
- [Federated Foundation Model for GI Endoscopy Images](https://mlsanity.com/paper/2505.24108/) (2025)
- [A New One-Shot Federated Learning Framework for Medical Imaging Classification with Feature-Guided Rectified Flow and Knowledge Distillation](https://mlsanity.com/paper/2507.19045/) (2025)
- [CFL-SparseMed: Communication-Efficient Federated Learning for Medical Imaging with Top-k Sparse Updates](https://mlsanity.com/paper/2510.24776/) (2025)
- [FedSQ: Optimized Weight Averaging via Fixed Gating](https://mlsanity.com/paper/2604.02990/) (2026)
- [Federated Medical Image Classification under Class and Domain Imbalance exploiting Synthetic Sample Generation](https://mlsanity.com/paper/2604.26324/) (2026)

## Abstract (arXiv)

The federated learning paradigm is wellsuited for the field of medical image analysis, as it can effectively cope with machine learning on isolated multicenter data while protecting the privacy of participating parties. However, current research on optimization algorithms in federated learning often focuses on limited datasets and scenarios, primarily centered around natural images, with insufficient comparative experiments in medical contexts. In this work, we conduct a comprehensive evaluation of several state-of-the-art federated learning algorithms in the context of medical imaging. We conduct a fair comparison of classification models trained using various federated learning algorithms across multiple medical imaging datasets. Additionally, we evaluate system performance metrics, such as communication cost and computational efficiency, while considering different federated learning architectures. Our findings show that medical imaging datasets pose substantial challenges for current federated learning optimization algorithms. No single algorithm consistently delivers optimal performance across all medical federated learning scenarios, and many optimization algorithms may underperform when applied to these datasets. Our experiments provide a benchmark and guidance for future research and application of federated learning in medical imaging contexts. Furthermore, we propose an efficient and robust method that combines generative techniques using denoising diffusion probabilistic models with label smoothing to augment datasets, widely enhancing the performance of federated learning on classification tasks across various medical imaging datasets. Our code will be released on GitHub, offering a reliable and comprehensive benchmark for future federated learning studies in medical imaging.