# Building LLM Agents by Incorporating Insights from Computer Systems

arXiv: https://arxiv.org/abs/2504.04485 · HTML: https://mlsanity.com/paper/2504.04485/

## Key facts

- Cited by 5 papers in the map (data through 14 Oct 2026).
- Placed in General LLM agent frameworks and benchmarks, one of 16 directions in LLM agents and tool use.
- Builds on 43 of its 54 references that are in the map.
- First posted on arXiv 6 Apr 2025.

## Placed in

- LLM agents and tool use / [General LLM agent frameworks and benchmarks](https://mlsanity.com/agents/general-llm-agent-frameworks-and-benchmarks/)

## Builds on (most cited first, 30 of 43)

- [GPT-4 Technical Report](https://mlsanity.com/paper/2303.08774/) (2023)
- [Proximal Policy Optimization Algorithms](https://mlsanity.com/paper/1707.06347/) (2017)
- [Chain-of-Thought Prompting Elicits Reasoning in Large Language Models](https://mlsanity.com/paper/2201.11903/) (2022)
- [Retrieval-Augmented Generation for Knowledge-Intensive NLP Tasks](https://mlsanity.com/paper/2005.11401/) (2020)
- [ReAct: Synergizing Reasoning and Acting in Language Models](https://mlsanity.com/paper/2210.03629/) (2022)
- [Self-Consistency Improves Chain of Thought Reasoning in Language Models](https://mlsanity.com/paper/2203.11171/) (2022)
- [Reflexion: Language Agents with Verbal Reinforcement Learning](https://mlsanity.com/paper/2303.11366/) (2023)
- [Generative Agents: Interactive Simulacra of Human Behavior](https://mlsanity.com/paper/2304.03442/) (2023)
- [Tree of Thoughts: Deliberate Problem Solving with Large Language Models](https://mlsanity.com/paper/2305.10601/) (2023)
- [Do As I Can, Not As I Say: Grounding Language in Robotic Affordances](https://mlsanity.com/paper/2204.01691/) (2022)
- [Voyager: An Open-Ended Embodied Agent with Large Language Models](https://mlsanity.com/paper/2305.16291/) (2023)
- [ToolLLM: Facilitating Large Language Models to Master 16000+ Real-world APIs](https://mlsanity.com/paper/2307.16789/) (2023)
- [WebGPT: Browser-assisted question-answering with human feedback](https://mlsanity.com/paper/2112.09332/) (2021)
- [SWE-agent: Agent-Computer Interfaces Enable Automated Software Engineering](https://mlsanity.com/paper/2405.15793/) (2024)
- [MemGPT: Towards LLMs as Operating Systems](https://mlsanity.com/paper/2310.08560/) (2023)
- [Gorilla: Large Language Model Connected with Massive APIs](https://mlsanity.com/paper/2305.15334/) (2023)
- [HuggingGPT: Solving AI Tasks with ChatGPT and its Friends in Hugging Face](https://mlsanity.com/paper/2303.17580/) (2023)
- [OpenHands: An Open Platform for AI Software Developers as Generalist Agents](https://mlsanity.com/paper/2407.16741/) (2024)
- [CogAgent: A Visual Language Model for GUI Agents](https://mlsanity.com/paper/2312.08914/) (2023)
- [LLM+P: Empowering Large Language Models with Optimal Planning Proficiency](https://mlsanity.com/paper/2304.11477/) (2023)
- [MineDojo: Building Open-Ended Embodied Agents with Internet-Scale Knowledge](https://mlsanity.com/paper/2206.08853/) (2022)
- [AppAgent: Multimodal Agents as Smartphone Users](https://mlsanity.com/paper/2312.13771/) (2023)
- [An Embodied Generalist Agent in 3D World](https://mlsanity.com/paper/2311.12871/) (2023)
- [AgentTuning: Enabling Generalized Agent Abilities for LLMs](https://mlsanity.com/paper/2310.12823/) (2023)
- [FireAct: Toward Language Agent Fine-tuning](https://mlsanity.com/paper/2310.05915/) (2023)
- [ShowUI: One Vision-Language-Action Model for GUI Visual Agent](https://mlsanity.com/paper/2411.17465/) (2024)
- [VideoAgent: A Memory-augmented Multimodal Agent for Video Understanding](https://mlsanity.com/paper/2403.11481/) (2024)
- [DigiRL: Training In-The-Wild Device-Control Agents with Autonomous Reinforcement Learning](https://mlsanity.com/paper/2406.11896/) (2024)
- [Agent Q: Advanced Reasoning and Learning for Autonomous AI Agents](https://mlsanity.com/paper/2408.07199/) (2024)
- [OS-Copilot: Towards Generalist Computer Agents with Self-Improvement](https://mlsanity.com/paper/2402.07456/) (2024)

## Built on by (most cited first, 5 of 5)

- [A Survey of Context Engineering for Large Language Models](https://mlsanity.com/paper/2507.13334/) (2025)
- [A Survey on the Safety and Security Threats of Computer-Using Agents: JARVIS or Ultron?](https://mlsanity.com/paper/2505.10924/) (2025)
- [Fundamentals of Building Autonomous LLM Agents](https://mlsanity.com/paper/2510.09244/) (2025)
- [Model-Native Computing Architecture: Envisioning Future System Architecture Through the Lens of Computer Architecture](https://mlsanity.com/paper/2606.00288/) (2026)
- [Dalek: A Constructive Agent Machine](https://mlsanity.com/paper/2609.03546/) (2026)

## Abstract (arXiv)

LLM-driven autonomous agents have emerged as a promising direction in recent years. However, many of these LLM agents are designed empirically or based on intuition, often lacking systematic design principles, which results in diverse agent structures with limited generality and scalability. In this paper, we advocate for building LLM agents by incorporating insights from computer systems. Inspired by the von Neumann architecture, we propose a structured framework for LLM agentic systems, emphasizing modular design and universal principles. Specifically, this paper first provides a comprehensive review of LLM agents from the computer system perspective, then identifies key challenges and future directions inspired by computer system design, and finally explores the learning mechanisms for LLM agents beyond the computer system. The insights gained from this comparative analysis offer a foundation for systematic LLM agent design and advancement.