# Temporal Gaussian Copula For Clinical Multivariate Time Series Data Imputation

arXiv: https://arxiv.org/abs/2504.02317 · HTML: https://mlsanity.com/paper/2504.02317/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 8 of its 20 references that are in the map.
- First posted on arXiv 3 Apr 2025.

## Builds on (most cited first, 8 of 8)

- [SCINet: Time Series Modeling and Forecasting with Sample Convolution and Interaction](https://mlsanity.com/paper/2106.09305/) (2021)
- [BRITS: Bidirectional Recurrent Imputation for Time Series](https://mlsanity.com/paper/1805.10572/) (2018)
- [GP-VAE: Deep Probabilistic Time Series Imputation](https://mlsanity.com/paper/1907.04155/) (2019)
- [Frequency-domain MLPs are More Effective Learners in Time Series Forecasting](https://mlsanity.com/paper/2311.06184/) (2023)
- [SAITS: Self-Attention-based Imputation for Time Series](https://mlsanity.com/paper/2202.08516/) (2022)
- [FiLM: Frequency improved Legendre Memory Model for Long-term Time Series Forecasting](https://mlsanity.com/paper/2205.08897/) (2022)
- [Koopa: Learning Non-stationary Time Series Dynamics with Koopman Predictors](https://mlsanity.com/paper/2305.18803/) (2023)
- [Real-time Mortality Prediction Using MIMIC-IV ICU Data Via Boosted Nonparametric Hazards](https://mlsanity.com/paper/2110.08949/) (2021)

## Abstract (arXiv)

The imputation of the Multivariate time series (MTS) is particularly challenging since the MTS typically contains irregular patterns of missing values due to various factors such as instrument failures, interference from irrelevant data, and privacy regulations. Existing statistical methods and deep learning methods have shown promising results in time series imputation. In this paper, we propose a Temporal Gaussian Copula Model (TGC) for three-order MTS imputation. The key idea is to leverage the Gaussian Copula to explore the cross-variable and temporal relationships based on the latent Gaussian representation. Subsequently, we employ an Expectation-Maximization (EM) algorithm to improve robustness in managing data with varying missing rates. Comprehensive experiments were conducted on three real-world MTS datasets. The results demonstrate that our TGC substantially outperforms the state-of-the-art imputation methods. Additionally, the TGC model exhibits stronger robustness to the varying missing ratios in the test dataset. Our code is available at https://github.com/MVL-Lab/TGC-MTS.