# BioAtt: Anatomical Prior Driven Low-Dose CT Denoising

arXiv: https://arxiv.org/abs/2504.01662 · HTML: https://mlsanity.com/paper/2504.01662/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 11 of its 35 references that are in the map.
- First posted on arXiv 2 Apr 2025.

## Builds on (most cited first, 11 of 11)

- [Squeeze-and-Excitation Networks](https://mlsanity.com/paper/1709.01507/) (2017)
- [CBAM: Convolutional Block Attention Module](https://mlsanity.com/paper/1807.06521/) (2018)
- [Extract Free Dense Labels from CLIP](https://mlsanity.com/paper/2112.01071/) (2021)
- [Medical SAM Adapter: Adapting Segment Anything Model for Medical Image Segmentation](https://mlsanity.com/paper/2304.12620/) (2023)
- [Low-Dose CT with a Residual Encoder-Decoder Convolutional Neural Network (RED-CNN)](https://mlsanity.com/paper/1702.00288/) (2017)
- [Low Dose CT Image Denoising Using a Generative Adversarial Network with Wasserstein Distance and Perceptual Loss](https://mlsanity.com/paper/1708.00961/) (2017)
- [CLIP Models are Few-shot Learners: Empirical Studies on VQA and Visual Entailment](https://mlsanity.com/paper/2203.07190/) (2022)
- [ASCON: Anatomy-aware Supervised Contrastive Learning Framework for Low-dose CT Denoising](https://mlsanity.com/paper/2307.12225/) (2023)
- [Deep Learning for Low-Dose CT Denoising](https://mlsanity.com/paper/1902.10127/) (2019)
- [CT Image Denoising with Perceptive Deep Neural Networks](https://mlsanity.com/paper/1702.07019/) (2017)
- [Cascaded Convolutional Neural Networks with Perceptual Loss for Low Dose CT Denoising](https://mlsanity.com/paper/2006.14738/) (2020)

## Abstract (arXiv)

Deep-learning-based denoising methods have significantly improved Low-Dose CT (LDCT) image quality. However, existing models often over-smooth important anatomical details due to their purely data-driven attention mechanisms. To address this challenge, we propose a novel LDCT denoising framework, BioAtt. The key innovation lies in attending anatomical prior distributions extracted from the pretrained vision-language model BiomedCLIP. These priors guide the denoising model to focus on anatomically relevant regions to suppress noise while preserving clinically relevant structures. We highlight three main contributions: BioAtt outperforms baseline and attention-based models in SSIM, PSNR, and RMSE across multiple anatomical regions. The framework introduces a new architectural paradigm by embedding anatomic priors directly into spatial attention. Finally, BioAtt attention maps provide visual confirmation that the improvements stem from anatomical guidance rather than increased model complexity.