# Learned Image Compression and Restoration for Digital Pathology

arXiv: https://arxiv.org/abs/2503.23862 · HTML: https://mlsanity.com/paper/2503.23862/

## Key facts

- Cited by 1 papers in the map (data through 14 Oct 2026).
- Builds on 21 of its 31 references that are in the map.
- First posted on arXiv 31 Mar 2025.

## Builds on (most cited first, 21 of 21)

- [PyTorch: An Imperative Style, High-Performance Deep Learning Library](https://mlsanity.com/paper/1912.01703/) (2019)
- [Deformable Convolutional Networks](https://mlsanity.com/paper/1703.06211/) (2017)
- [Variational image compression with a scale hyperprior](https://mlsanity.com/paper/1802.01436/) (2018)
- [End-to-end Optimized Image Compression](https://mlsanity.com/paper/1611.01704/) (2016)
- [Deformable ConvNets v2: More Deformable, Better Results](https://mlsanity.com/paper/1811.11168/) (2018)
- [Joint Autoregressive and Hierarchical Priors for Learned Image Compression](https://mlsanity.com/paper/1809.02736/) (2018)
- [Learned Image Compression with Discretized Gaussian Mixture Likelihoods and Attention Modules](https://mlsanity.com/paper/2001.01568/) (2020)
- [Deeply-Recursive Convolutional Network for Image Super-Resolution](https://mlsanity.com/paper/1511.04491/) (2015)
- [ELIC: Efficient Learned Image Compression with Unevenly Grouped Space-Channel Contextual Adaptive Coding](https://mlsanity.com/paper/2203.10886/) (2022)
- [CompressAI: a PyTorch library and evaluation platform for end-to-end compression research](https://mlsanity.com/paper/2011.03029/) (2020)
- [Channel-wise Autoregressive Entropy Models for Learned Image Compression](https://mlsanity.com/paper/2007.08739/) (2020)
- [Recurrent Residual Convolutional Neural Network based on U-Net (R2U-Net) for Medical Image Segmentation](https://mlsanity.com/paper/1802.06955/) (2018)
- [The Devil Is in the Details: Window-based Attention for Image Compression](https://mlsanity.com/paper/2203.08450/) (2022)
- [Context-adaptive Entropy Model for End-to-end Optimized Image Compression](https://mlsanity.com/paper/1809.10452/) (2018)
- [MLIC: Multi-Reference Entropy Model for Learned Image Compression](https://mlsanity.com/paper/2211.07273/) (2022)
- [MLIC++: Linear Complexity Multi-Reference Entropy Modeling for Learned Image Compression](https://mlsanity.com/paper/2307.15421/) (2023)
- [DRFN: Deep Recurrent Fusion Network for Single-Image Super-Resolution with Large Factors](https://mlsanity.com/paper/1908.08837/) (2019)
- [Image Super-Resolution via Dual-State Recurrent Networks](https://mlsanity.com/paper/1805.02704/) (2018)
- [R2U++: A Multiscale Recurrent Residual U-Net with Dense Skip Connections for Medical Image Segmentation](https://mlsanity.com/paper/2206.01793/) (2022)
- [Feedback U-net for Cell Image Segmentation](https://mlsanity.com/paper/2004.14581/) (2020)
- [Learned Image Compression for HE-stained Histopathological Images via Stain Deconvolution](https://mlsanity.com/paper/2406.12623/) (2024)

## Built on by (most cited first, 1 of 1)

- [Multimodal Model for Computational Pathology:Representation Learning and Image Compression](https://mlsanity.com/paper/2603.18660/) (2026)

## Abstract (arXiv)

Digital pathology images play a crucial role in medical diagnostics, but their ultra-high resolution and large file sizes pose significant challenges for storage, transmission, and real-time visualization. To address these issues, we propose CLERIC, a novel deep learning-based image compression framework designed specifically for whole slide images (WSIs). CLERIC integrates a learnable lifting scheme and advanced convolutional techniques to enhance compression efficiency while preserving critical pathological details. Our framework employs a lifting-scheme transform in the analysis stage to decompose images into low- and high-frequency components, enabling more structured latent representations. These components are processed through parallel encoders incorporating Deformable Residual Blocks (DRB) and Recurrent Residual Blocks (R2B) to improve feature extraction and spatial adaptability. The synthesis stage applies an inverse lifting transform for effective image reconstruction, ensuring high-fidelity restoration of fine-grained tissue structures. We evaluate CLERIC on a digital pathology image dataset and compare its performance against state-of-the-art learned image compression (LIC) models. Experimental results demonstrate that CLERIC achieves superior rate-distortion (RD) performance, significantly reducing storage requirements while maintaining high diagnostic image quality. Our study highlights the potential of deep learning-based compression in digital pathology, facilitating efficient data management and long-term storage while ensuring seamless integration into clinical workflows and AI-assisted diagnostic systems. Code and models are available at: https://github.com/pnu-amilab/CLERIC.