# Language-Guided Trajectory Traversal in Disentangled Stable Diffusion Latent Space for Factorized Medical Image Generation

arXiv: https://arxiv.org/abs/2503.23623 · HTML: https://mlsanity.com/paper/2503.23623/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Placed in Medical imaging and segmentation, one of 14 directions in Diffusion models.
- Builds on 30 of its 41 references that are in the map.
- First posted on arXiv 30 Mar 2025.

## Placed in

- Diffusion models / [Medical imaging and segmentation](https://mlsanity.com/diffusion/medical-imaging-and-segmentation/)

## Builds on (most cited first, 30 of 30)

- [High-Resolution Image Synthesis with Latent Diffusion Models](https://mlsanity.com/paper/2112.10752/) (2021)
- [The Unreasonable Effectiveness of Deep Features as a Perceptual Metric](https://mlsanity.com/paper/1801.03924/) (2018)
- [Denoising Diffusion Implicit Models](https://mlsanity.com/paper/2010.02502/) (2020)
- [EfficientNet: Rethinking Model Scaling for Convolutional Neural Networks](https://mlsanity.com/paper/1905.11946/) (2019)
- [FiLM: Visual Reasoning with a General Conditioning Layer](https://mlsanity.com/paper/1709.07871/) (2017)
- [Arbitrary Style Transfer in Real-time with Adaptive Instance Normalization](https://mlsanity.com/paper/1703.06868/) (2017)
- [CheXpert: A Large Chest Radiograph Dataset with Uncertainty Labels and Expert Comparison](https://mlsanity.com/paper/1901.07031/) (2019)
- [Learning Transferable Features with Deep Adaptation Networks](https://mlsanity.com/paper/1502.02791/) (2015)
- [Adversarial Discriminative Domain Adaptation](https://mlsanity.com/paper/1702.05464/) (2017)
- [Semantic Image Synthesis with Spatially-Adaptive Normalization](https://mlsanity.com/paper/1903.07291/) (2019)
- [InfoGAN: Interpretable Representation Learning by Information Maximizing Generative Adversarial Nets](https://mlsanity.com/paper/1606.03657/) (2016)
- [Pseudo Numerical Methods for Diffusion Models on Manifolds](https://mlsanity.com/paper/2202.09778/) (2022)
- [Interpreting the Latent Space of GANs for Semantic Face Editing](https://mlsanity.com/paper/1907.10786/) (2019)
- [DiffusionCLIP: Text-Guided Diffusion Models for Robust Image Manipulation](https://mlsanity.com/paper/2110.02711/) (2021)
- [Disentangling by Factorising](https://mlsanity.com/paper/1802.05983/) (2018)
- [GANSpace: Discovering Interpretable GAN Controls](https://mlsanity.com/paper/2004.02546/) (2020)
- [Skin Lesion Analysis Toward Melanoma Detection: A Challenge at the 2017 International Symposium on Biomedical Imaging (ISBI), Hosted by the International Skin Imaging Collaboration (ISIC)](https://mlsanity.com/paper/1710.05006/) (2017)
- [Closed-Form Factorization of Latent Semantics in GANs](https://mlsanity.com/paper/2007.06600/) (2020)
- [InterFaceGAN: Interpreting the Disentangled Face Representation Learned by GANs](https://mlsanity.com/paper/2005.09635/) (2020)
- [BCN20000: Dermoscopic Lesions in the Wild](https://mlsanity.com/paper/1908.02288/) (2019)
- [Deep Structural Causal Models for Tractable Counterfactual Inference](https://mlsanity.com/paper/2006.06485/) (2020)
- [Explaining in Style: Training a GAN to explain a classifier in StyleSpace](https://mlsanity.com/paper/2104.13369/) (2021)
- [Uncovering the Disentanglement Capability in Text-to-Image Diffusion Models](https://mlsanity.com/paper/2212.08698/) (2022)
- [Not Only Generative Art: Stable Diffusion for Content-Style Disentanglement in Art Analysis](https://mlsanity.com/paper/2304.10278/) (2023)
- [PRISM: High-Resolution & Precise Counterfactual Medical Image Generation using Language-guided Stable Diffusion](https://mlsanity.com/paper/2503.00196/) (2025)
- [B'ezierGAN: Automatic Generation of Smooth Curves from Interpretable Low-Dimensional Parameters](https://mlsanity.com/paper/1808.08871/) (2018)
- [Artifact-Based Domain Generalization of Skin Lesion Models](https://mlsanity.com/paper/2208.09756/) (2022)
- [Learning Cross-domain Generalizable Features by Representation Disentanglement](https://mlsanity.com/paper/2003.00321/) (2020)
- [Lung Swapping Autoencoder: Learning a Disentangled Structure-texture Representation of Chest Radiographs](https://mlsanity.com/paper/2201.07344/) (2022)
- [Discovering interpretable models of scientific image data with deep learning](https://mlsanity.com/paper/2402.03115/) (2024)

## Abstract (arXiv)

Text-to-image diffusion models have demonstrated a remarkable ability to generate photorealistic images from natural language prompts. These high-resolution, language-guided synthesized images are essential for the explainability of disease or exploring causal relationships. However, their potential for disentangling and controlling latent factors of variation in specialized domains like medical imaging remains under-explored. In this work, we present the first investigation of the power of pre-trained vision-language foundation models, once fine-tuned on medical image datasets, to perform latent disentanglement for factorized medical image generation and interpolation. Through extensive experiments on chest X-ray and skin datasets, we illustrate that fine-tuned, language-guided Stable Diffusion inherently learns to factorize key attributes for image generation, such as the patient's anatomical structures or disease diagnostic features. We devise a framework to identify, isolate, and manipulate key attributes through latent space trajectory traversal of generative models, facilitating precise control over medical image synthesis.