# EchoFlow: A Foundation Model for Cardiac Ultrasound Image and Video Generation

arXiv: https://arxiv.org/abs/2503.22357 · HTML: https://mlsanity.com/paper/2503.22357/

## Key facts

- Cited by 5 papers in the map (data through 14 Oct 2026).
- Placed in Medical imaging and segmentation, one of 14 directions in Diffusion models.
- Builds on 39 of its 59 references that are in the map.
- First posted on arXiv 28 Mar 2025.

## Placed in

- Diffusion models / [Medical imaging and segmentation](https://mlsanity.com/diffusion/medical-imaging-and-segmentation/)

## Builds on (most cited first, 30 of 39)

- [Attention Is All You Need](https://mlsanity.com/paper/1706.03762/) (2017)
- [Denoising Diffusion Probabilistic Models](https://mlsanity.com/paper/2006.11239/) (2020)
- [U-Net: Convolutional Networks for Biomedical Image Segmentation](https://mlsanity.com/paper/1505.04597/) (2015)
- [High-Resolution Image Synthesis with Latent Diffusion Models](https://mlsanity.com/paper/2112.10752/) (2021)
- [Diffusion Models Beat GANs on Image Synthesis](https://mlsanity.com/paper/2105.05233/) (2021)
- [Photorealistic Text-to-Image Diffusion Models with Deep Language Understanding](https://mlsanity.com/paper/2205.11487/) (2022)
- [Scalable Diffusion Models with Transformers](https://mlsanity.com/paper/2212.09748/) (2022)
- [Classifier-Free Diffusion Guidance](https://mlsanity.com/paper/2207.12598/) (2022)
- [Flow Matching for Generative Modeling](https://mlsanity.com/paper/2210.02747/) (2022)
- [Generative Adversarial Networks](https://mlsanity.com/paper/2203.00667/) (2022)
- [Scaling Rectified Flow Transformers for High-Resolution Image Synthesis](https://mlsanity.com/paper/2403.03206/) (2024)
- [Large Scale GAN Training for High Fidelity Natural Image Synthesis](https://mlsanity.com/paper/1809.11096/) (2018)
- [InstructPix2Pix: Learning to Follow Image Editing Instructions](https://mlsanity.com/paper/2211.09800/) (2022)
- [Stable Video Diffusion: Scaling Latent Video Diffusion Models to Large Datasets](https://mlsanity.com/paper/2311.15127/) (2023)
- [Video Diffusion Models](https://mlsanity.com/paper/2204.03458/) (2022)
- [Rethinking Atrous Convolution for Semantic Image Segmentation](https://mlsanity.com/paper/1706.05587/) (2017)
- [Imagen Video: High Definition Video Generation with Diffusion Models](https://mlsanity.com/paper/2210.02303/) (2022)
- [Make-A-Video: Text-to-Video Generation without Text-Video Data](https://mlsanity.com/paper/2209.14792/) (2022)
- [Align your Latents: High-Resolution Video Synthesis with Latent Diffusion Models](https://mlsanity.com/paper/2304.08818/) (2023)
- [Pixel Recurrent Neural Networks](https://mlsanity.com/paper/1601.06759/) (2016)
- [Extracting Training Data from Diffusion Models](https://mlsanity.com/paper/2301.13188/) (2023)
- [Text2Video-Zero: Text-to-Image Diffusion Models are Zero-Shot Video Generators](https://mlsanity.com/paper/2303.13439/) (2023)
- [Latte: Latent Diffusion Transformer for Video Generation](https://mlsanity.com/paper/2401.03048/) (2024)
- [Pyramidal Flow Matching for Efficient Video Generative Modeling](https://mlsanity.com/paper/2410.05954/) (2024)
- [Attention Gated Networks: Learning to Leverage Salient Regions in Medical Images](https://mlsanity.com/paper/1808.08114/) (2018)
- [Very Deep VAEs Generalize Autoregressive Models and Can Outperform Them on Images](https://mlsanity.com/paper/2011.10650/) (2020)
- [Improving the Training of Rectified Flows](https://mlsanity.com/paper/2405.20320/) (2024)
- [Don't Generate Me: Training Differentially Private Generative Models with Sinkhorn Divergence](https://mlsanity.com/paper/2111.01177/) (2021)
- [Sketch guided and progressive growing GAN for realistic and editable ultrasound image synthesis](https://mlsanity.com/paper/2204.06929/) (2022)
- [Ultrasound Video Transformers for Cardiac Ejection Fraction Estimation](https://mlsanity.com/paper/2107.00977/) (2021)

## Built on by (most cited first, 5 of 5)

- [CTFlow: Video-Inspired Latent Flow Matching for 3D CT Synthesis](https://mlsanity.com/paper/2508.12900/) (2025)
- [Self-supervised Learning of Echocardiographic Video Representations via Online Cluster Distillation](https://mlsanity.com/paper/2506.11777/) (2025)
- [EchoLVFM: One-Step Video Generation via Latent Flow Matching for Echocardiogram Synthesis](https://mlsanity.com/paper/2603.13967/) (2026)
- [SigVLP: Sigmoid Volume-Language Pre-Training for Self-Supervised CT-Volume Adaptive Representation Learning](https://mlsanity.com/paper/2602.21735/) (2026)
- [Focus, Align, and Diffuse: Time-Series-Aware Keyframe Diffusion for Cardiac Dynamic Synthesis from Sparse Observations](https://mlsanity.com/paper/2610.19050/) (2026)

## Abstract (arXiv)

Advances in deep learning have significantly enhanced medical image analysis, yet the availability of large-scale medical datasets remains constrained by patient privacy concerns. We present EchoFlow, a novel framework designed to generate high-quality, privacy-preserving synthetic echocardiogram images and videos. EchoFlow comprises four key components: an adversarial variational autoencoder for defining an efficient latent representation of cardiac ultrasound images, a latent image flow matching model for generating accurate latent echocardiogram images, a latent re-identification model to ensure privacy by filtering images anatomically, and a latent video flow matching model for animating latent images into realistic echocardiogram videos conditioned on ejection fraction. We rigorously evaluate our synthetic datasets on the clinically relevant task of ejection fraction regression and demonstrate, for the first time, that downstream models trained exclusively on EchoFlow-generated synthetic datasets achieve performance parity with models trained on real datasets. We release our models and synthetic datasets, enabling broader, privacy-compliant research in medical ultrasound imaging at https://huggingface.co/spaces/HReynaud/EchoFlow.