# NeuroLIP: Interpretable and Fair Cross-Modal Alignment of fMRI and Phenotypic Text

arXiv: https://arxiv.org/abs/2503.21964 · HTML: https://mlsanity.com/paper/2503.21964/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 8 of its 28 references that are in the map.
- First posted on arXiv 27 Mar 2025.

## Builds on (most cited first, 8 of 8)

- [Learning Transferable Visual Models From Natural Language Supervision](https://mlsanity.com/paper/2103.00020/) (2021)
- [Sigmoid Loss for Language Image Pre-Training](https://mlsanity.com/paper/2303.15343/) (2023)
- [Unsupervised Deep Embedding for Clustering Analysis](https://mlsanity.com/paper/1511.06335/) (2015)
- [A Reductions Approach to Fair Classification](https://mlsanity.com/paper/1803.02453/) (2018)
- [FairCLIP: Harnessing Fairness in Vision-Language Learning](https://mlsanity.com/paper/2403.19949/) (2024)
- [FLAIR: VLM with Fine-grained Language-informed Image Representations](https://mlsanity.com/paper/2412.03561/) (2024)
- [Harvard Glaucoma Fairness: A Retinal Nerve Disease Dataset for Fairness Learning and Fair Identity Normalization](https://mlsanity.com/paper/2306.09264/) (2023)
- [Risk of Training Diagnostic Algorithms on Data with Demographic Bias](https://mlsanity.com/paper/2005.10050/) (2020)

## Abstract (arXiv)

Integrating functional magnetic resonance imaging (fMRI) connectivity data with phenotypic textual descriptors (e.g., disease label, demographic data) holds significant potential to advance our understanding of neurological conditions. However, existing cross-modal alignment methods often lack interpretability and risk introducing biases by encoding sensitive attributes together with diagnostic-related features. In this work, we propose NeuroLIP, a novel cross-modal contrastive learning framework. We introduce text token-conditioned attention (TTCA) and cross-modal alignment via localized tokens (CALT) to the brain region-level embeddings with each disease-related phenotypic token. It improves interpretability via token-level attention maps, revealing brain region-disease associations. To mitigate bias, we propose a loss for sensitive attribute disentanglement that maximizes the attention distance between disease tokens and sensitive attribute tokens, reducing unintended correlations in downstream predictions. Additionally, we incorporate a negative gradient technique that reverses the sign of CALT loss on sensitive attributes, further discouraging the alignment of these features. Experiments on neuroimaging datasets (ABIDE and ADHD-200) demonstrate NeuroLIP's superiority in terms of fairness metrics while maintaining the overall best standard metric performance. Qualitative visualization of attention maps highlights neuroanatomical patterns aligned with diagnostic characteristics, validated by the neuroscientific literature. Our work advances the development of transparent and equitable neuroimaging AI.