# MindfulLIME: A Stable Solution for Explanations of Machine Learning Models with Enhanced Localization Precision -- A Medical Image Case Study

arXiv: https://arxiv.org/abs/2503.20758 · HTML: https://mlsanity.com/paper/2503.20758/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 34 of its 70 references that are in the map.
- First posted on arXiv 25 Mar 2025.

## Builds on (most cited first, 30 of 34)

- [Deep Residual Learning for Image Recognition](https://mlsanity.com/paper/1512.03385/) (2015)
- [Very Deep Convolutional Networks for Large-Scale Image Recognition](https://mlsanity.com/paper/1409.1556/) (2014)
- [Grad-CAM: Visual Explanations from Deep Networks via Gradient-based Localization](https://mlsanity.com/paper/1610.02391/) (2016)
- [Densely Connected Convolutional Networks](https://mlsanity.com/paper/1608.06993/) (2016)
- [A Unified Approach to Interpreting Model Predictions](https://mlsanity.com/paper/1705.07874/) (2017)
- [Rethinking the Inception Architecture for Computer Vision](https://mlsanity.com/paper/1512.00567/) (2015)
- [MobileNetV2: Inverted Residuals and Linear Bottlenecks](https://mlsanity.com/paper/1801.04381/) (2018)
- [Going Deeper with Convolutions](https://mlsanity.com/paper/1409.4842/) (2014)
- [Axiomatic Attribution for Deep Networks](https://mlsanity.com/paper/1703.01365/) (2017)
- [Visualizing and Understanding Convolutional Networks](https://mlsanity.com/paper/1311.2901/) (2013)
- [Explainable Artificial Intelligence (XAI): Concepts, Taxonomies, Opportunities and Challenges toward Responsible AI](https://mlsanity.com/paper/1910.10045/) (2019)
- [CheXpert: A Large Chest Radiograph Dataset with Uncertainty Labels and Expert Comparison](https://mlsanity.com/paper/1901.07031/) (2019)
- [SmoothGrad: removing noise by adding noise](https://mlsanity.com/paper/1706.03825/) (2017)
- [RISE: Randomized Input Sampling for Explanation of Black-box Models](https://mlsanity.com/paper/1806.07421/) (2018)
- [Modeling Tabular data using Conditional GAN](https://mlsanity.com/paper/1907.00503/) (2019)
- [Towards Robust Interpretability with Self-Explaining Neural Networks](https://mlsanity.com/paper/1806.07538/) (2018)
- [Fooling LIME and SHAP: Adversarial Attacks on Post hoc Explanation Methods](https://mlsanity.com/paper/1911.02508/) (2019)
- [On the Robustness of Interpretability Methods](https://mlsanity.com/paper/1806.08049/) (2018)
- [VinDr-CXR: An open dataset of chest X-rays with radiologist's annotations](https://mlsanity.com/paper/2012.15029/) (2020)
- [What do different evaluation metrics tell us about saliency models?](https://mlsanity.com/paper/1604.03605/) (2016)
- [Explainable artificial intelligence (XAI) in deep learning-based medical image analysis](https://mlsanity.com/paper/2107.10912/) (2021)
- [Unrestricted Permutation forces Extrapolation: Variable Importance Requires at least One More Model, or There Is No Free Variable Importance](https://mlsanity.com/paper/1905.03151/) (2019)
- [S-LIME: Stabilized-LIME for Model Explanation](https://mlsanity.com/paper/2106.07875/) (2021)
- [ALIME: Autoencoder Based Approach for Local Interpretability](https://mlsanity.com/paper/1909.02437/) (2019)
- [OptiLIME: Optimized LIME Explanations for Diagnostic Computer Algorithms](https://mlsanity.com/paper/2006.05714/) (2020)
- [What does LIME really see in images?](https://mlsanity.com/paper/2102.06307/) (2021)
- [Locally Interpretable Models and Effects based on Supervised Partitioning (LIME-SUP)](https://mlsanity.com/paper/1806.00663/) (2018)
- [A study of data and label shift in the LIME framework](https://mlsanity.com/paper/1910.14421/) (2019)
- [Explainable Deep Learning in Healthcare: A Methodological Survey from an Attribution View](https://mlsanity.com/paper/2112.02625/) (2021)
- [A Modified Perturbed Sampling Method for Local Interpretable Model-agnostic Explanation](https://mlsanity.com/paper/2002.07434/) (2020)

## Abstract (arXiv)

Ensuring transparency in machine learning decisions is critically important, especially in sensitive sectors such as healthcare, finance, and justice. Despite this, some popular explainable algorithms, such as Local Interpretable Model-agnostic Explanations (LIME), often produce unstable explanations due to the random generation of perturbed samples. Random perturbation introduces small changes or noise to modified instances of the original data, leading to inconsistent explanations. Even slight variations in the generated samples significantly affect the explanations provided by such models, undermining trust and hindering the adoption of interpretable models. To address this challenge, we propose MindfulLIME, a novel algorithm that intelligently generates purposive samples using a graph-based pruning algorithm and uncertainty sampling. MindfulLIME substantially improves the consistency of visual explanations compared to random sampling approaches. Our experimental evaluation, conducted on a widely recognized chest X-ray dataset, confirms MindfulLIME's stability with a 100% success rate in delivering reliable explanations under identical conditions. Additionally, MindfulLIME improves the localization precision of visual explanations by reducing the distance between the generated explanations and the actual local annotations compared to LIME. We also performed comprehensive experiments considering various segmentation algorithms and sample numbers, focusing on stability, quality, and efficiency. The results demonstrate the outstanding performance of MindfulLIME across different segmentation settings, generating fewer high-quality samples within a reasonable processing time. By addressing the stability limitations of LIME in image data, MindfulLIME enhances the trustworthiness and interpretability of machine learning models in specific medical imaging applications, a critical domain.