# Domain-incremental White Blood Cell Classification with Privacy-aware Continual Learning

arXiv: https://arxiv.org/abs/2503.19819 · HTML: https://mlsanity.com/paper/2503.19819/

## Key facts

- Cited by 3 papers in the map (data through 14 Oct 2026).
- Builds on 15 of its 24 references that are in the map.
- First posted on arXiv 25 Mar 2025.

## Builds on (most cited first, 15 of 15)

- [Overcoming catastrophic forgetting in neural networks](https://mlsanity.com/paper/1612.00796/) (2016)
- [Learning without Forgetting](https://mlsanity.com/paper/1606.09282/) (2016)
- [Gradient Episodic Memory for Continual Learning](https://mlsanity.com/paper/1706.08840/) (2017)
- [Experience Replay for Continual Learning](https://mlsanity.com/paper/1811.11682/) (2018)
- [Efficient Lifelong Learning with A-GEM](https://mlsanity.com/paper/1812.00420/) (2018)
- [Dark Experience for General Continual Learning: a Strong, Simple Baseline](https://mlsanity.com/paper/2004.07211/) (2020)
- [An Empirical Investigation of Catastrophic Forgetting in Gradient-Based Neural Networks](https://mlsanity.com/paper/1312.6211/) (2013)
- [Avalanche: an End-to-End Library for Continual Learning](https://mlsanity.com/paper/2104.00405/) (2021)
- [Don't forget, there is more than forgetting: new metrics for Continual Learning](https://mlsanity.com/paper/1810.13166/) (2018)
- [Latent Replay for Real-Time Continual Learning](https://mlsanity.com/paper/1912.01100/) (2019)
- [DinoBloom: A Foundation Model for Generalizable Cell Embeddings in Hematology](https://mlsanity.com/paper/2404.05022/) (2024)
- [Continual Learning in Medical Image Analysis: A Comprehensive Review of Recent Advancements and Future Prospects](https://mlsanity.com/paper/2312.17004/) (2023)
- [A Continual Learning Approach for Cross-Domain White Blood Cell Classification](https://mlsanity.com/paper/2308.12679/) (2023)
- [Continual Domain Incremental Learning for Privacy-aware Digital Pathology](https://mlsanity.com/paper/2409.06455/) (2024)
- [Concept Drift Challenge in Multimedia Anomaly Detection: A Case Study with Facial Datasets](https://mlsanity.com/paper/2207.13430/) (2022)

## Built on by (most cited first, 3 of 3)

- [Attention-based Generative Latent Replay: A Continual Learning Approach for WSI Analysis](https://mlsanity.com/paper/2505.08524/) (2025)
- [CoRE: Concept-Reasoning Expansion for Continual Brain Lesion Segmentation](https://mlsanity.com/paper/2604.25376/) (2026)
- [Retrieval-Augmented Vision Foundation Models for Robust Leukemia Cell Classification across Multiple Microscopy Datasets](https://mlsanity.com/paper/2608.10657/) (2026)

## Abstract (arXiv)

White blood cell (WBC) classification plays a vital role in hematology for diagnosing various medical conditions. However, it faces significant challenges due to domain shifts caused by variations in sample sources (e.g., blood or bone marrow) and differing imaging conditions across hospitals. Traditional deep learning models often suffer from catastrophic forgetting in such dynamic environments, while foundation models, though generally robust, experience performance degradation when the distribution of inference data differs from that of the training data. To address these challenges, we propose a generative replay-based Continual Learning (CL) strategy designed to prevent forgetting in foundation models for WBC classification. Our method employs lightweight generators to mimic past data with a synthetic latent representation to enable privacy-preserving replay. To showcase the effectiveness, we carry out extensive experiments with a total of four datasets with different task ordering and four backbone models including ResNet50, RetCCL, CTransPath, and UNI. Experimental results demonstrate that conventional fine-tuning methods degrade performance on previously learned tasks and struggle with domain shifts. In contrast, our continual learning strategy effectively mitigates catastrophic forgetting, preserving model performance across varying domains. This work presents a practical solution for maintaining reliable WBC classification in real-world clinical settings, where data distributions frequently evolve.