# MedAgent-Pro: Towards Evidence-based Multi-modal Medical Diagnosis via Reasoning Agentic Workflow

arXiv: https://arxiv.org/abs/2503.18968 · HTML: https://mlsanity.com/paper/2503.18968/

## Key facts

- Cited by 73 papers in the map (data through 14 Oct 2026).
- Placed in Clinical and biomedical applications, one of 17 directions in LLM reasoning.
- Builds on 56 of its 96 references that are in the map.
- First posted on arXiv 21 Mar 2025.

## Placed in

- LLM reasoning / [Clinical and biomedical applications](https://mlsanity.com/lr/clinical-and-biomedical-applications/)
- LLM agents and tool use / [Medical and scientific domain agents](https://mlsanity.com/agents/medical-and-scientific-domain-agents/)

## Builds on (most cited first, 30 of 56)

- [U-Net: Convolutional Networks for Biomedical Image Segmentation](https://mlsanity.com/paper/1505.04597/) (2015)
- [GPT-4 Technical Report](https://mlsanity.com/paper/2303.08774/) (2023)
- [Visual Instruction Tuning](https://mlsanity.com/paper/2304.08485/) (2023)
- [DeepSeek-R1: Incentivizing Reasoning Capability in LLMs via Reinforcement Learning](https://mlsanity.com/paper/2501.12948/) (2025)
- [Reflexion: Language Agents with Verbal Reinforcement Learning](https://mlsanity.com/paper/2303.11366/) (2023)
- [Qwen2-VL: Enhancing Vision-Language Model's Perception of the World at Any Resolution](https://mlsanity.com/paper/2409.12191/) (2024)
- [InternVL: Scaling up Vision Foundation Models and Aligning for Generic Visual-Linguistic Tasks](https://mlsanity.com/paper/2312.14238/) (2023)
- [Do As I Can, Not As I Say: Grounding Language in Robotic Affordances](https://mlsanity.com/paper/2204.01691/) (2022)
- [Large Language Models Encode Clinical Knowledge](https://mlsanity.com/paper/2212.13138/) (2022)
- [CAMEL: Communicative Agents for "Mind" Exploration of Large Language Model Society](https://mlsanity.com/paper/2303.17760/) (2023)
- [LLaVA-Med: Training a Large Language-and-Vision Assistant for Biomedicine in One Day](https://mlsanity.com/paper/2306.00890/) (2023)
- [Inner Monologue: Embodied Reasoning through Planning with Language Models](https://mlsanity.com/paper/2207.05608/) (2022)
- [Janus-Pro: Unified Multimodal Understanding and Generation with Data and Model Scaling](https://mlsanity.com/paper/2501.17811/) (2025)
- [ChemCrow: Augmenting large-language models with chemistry tools](https://mlsanity.com/paper/2304.05376/) (2023)
- [BiomedCLIP: a multimodal biomedical foundation model pretrained from fifteen million scientific image-text pairs](https://mlsanity.com/paper/2303.00915/) (2023)
- [Medical SAM Adapter: Adapting Segment Anything Model for Medical Image Segmentation](https://mlsanity.com/paper/2304.12620/) (2023)
- [PathVQA: 30000+ Questions for Medical Visual Question Answering](https://mlsanity.com/paper/2003.10286/) (2020)
- [SLAKE: A Semantically-Labeled Knowledge-Enhanced Dataset for Medical Visual Question Answering](https://mlsanity.com/paper/2102.09542/) (2021)
- [Emergent World Representations: Exploring a Sequence Model Trained on a Synthetic Task](https://mlsanity.com/paper/2210.13382/) (2022)
- [Med-Flamingo: a Multimodal Medical Few-shot Learner](https://mlsanity.com/paper/2307.15189/) (2023)
- [PMC-VQA: Visual Instruction Tuning for Medical Visual Question Answering](https://mlsanity.com/paper/2305.10415/) (2023)
- [Big Self-Supervised Models Advance Medical Image Classification](https://mlsanity.com/paper/2101.05224/) (2021)
- [MedAgents: Large Language Models as Collaborators for Zero-shot Medical Reasoning](https://mlsanity.com/paper/2311.10537/) (2023)
- [VisionZip: Longer is Better but Not Necessary in Vision Language Models](https://mlsanity.com/paper/2412.04467/) (2024)
- [TidyBot: Personalized Robot Assistance with Large Language Models](https://mlsanity.com/paper/2305.05658/) (2023)
- [AutoAgents: A Framework for Automatic Agent Generation](https://mlsanity.com/paper/2309.17288/) (2023)
- [MDAgents: An Adaptive Collaboration of LLMs for Medical Decision-Making](https://mlsanity.com/paper/2404.15155/) (2024)
- [Medical SAM 2: Segment medical images as video via Segment Anything Model 2](https://mlsanity.com/paper/2408.00874/) (2024)
- [MAIRA-2: Grounded Radiology Report Generation](https://mlsanity.com/paper/2406.04449/) (2024)
- [Emergent autonomous scientific research capabilities of large language models](https://mlsanity.com/paper/2304.05332/) (2023)

## Built on by (most cited first, 30 of 73)

- [Lingshu: A Generalist Foundation Model for Unified Multimodal Medical Understanding and Reasoning](https://mlsanity.com/paper/2506.07044/) (2025)
- [A Comprehensive Survey in LLM(-Agent) Full Stack Safety: Data, Training and Deployment](https://mlsanity.com/paper/2504.15585/) (2025)
- [A Survey of LLM-based Deep Search Agents: Paradigm, Optimization, Evaluation, and Challenges](https://mlsanity.com/paper/2508.05668/) (2025)
- [LLM-based Agents Suffer from Hallucinations: A Survey of Taxonomy, Methods, and Directions](https://mlsanity.com/paper/2509.18970/) (2025)
- [A Survey of Agentic Reasoning for Large Language Models: Towards Recursively Self-Improving and Collective Agents](https://mlsanity.com/paper/2601.12538/) (2026)
- [VisionThink: Smart and Efficient Vision Language Model via Reinforcement Learning](https://mlsanity.com/paper/2507.13348/) (2025)
- [PathAgent: Toward Interpretable Analysis of Whole-slide Pathology Images via Large Language Model-based Agentic Reasoning](https://mlsanity.com/paper/2511.17052/) (2025)
- [Ophiuchus: Incentivizing Tool-augmented "Think with Images" for Joint Medical Segmentation, Understanding and Reasoning](https://mlsanity.com/paper/2512.14157/) (2025)
- [MedSAM-Agent: Empowering Interactive Medical Image Segmentation with Multi-turn Agentic Reinforcement Learning](https://mlsanity.com/paper/2602.03320/) (2026)
- [PathReasoner-R1: Instilling Structured Reasoning into Pathology Vision-Language Model via Knowledge-Guided Policy Optimization](https://mlsanity.com/paper/2601.21617/) (2026)
- [MTBBench: A Multimodal Sequential Clinical Decision-Making Benchmark in Oncology](https://mlsanity.com/paper/2511.20490/) (2025)
- [Evo-MedAgent: Beyond One-Shot Diagnosis with Agents That Remember, Reflect, and Improve](https://mlsanity.com/paper/2604.14475/) (2026)
- [RadAgent: A tool-using AI agent for stepwise interpretation of chest computed tomography](https://mlsanity.com/paper/2604.15231/) (2026)
- [AgenticRed: Evolving Agentic Systems for Red-Teaming](https://mlsanity.com/paper/2601.13518/) (2026)
- [3DMedAgent: Unified Perception-to-Understanding for 3D Medical Analysis](https://mlsanity.com/paper/2602.18064/) (2026)
- [MedOpenClaw and MedFlowBench: Auditing Medical Agents in Full-Study Workflows](https://mlsanity.com/paper/2603.24649/) (2026)
- [AT-CXR: Uncertainty-Aware Agentic Triage for Chest X-rays](https://mlsanity.com/paper/2508.19322/) (2025)
- [LungNoduleAgent: A Collaborative Multi-Agent System for Precision Diagnosis of Lung Nodules](https://mlsanity.com/paper/2511.21042/) (2025)
- [MEDVISTAGYM: A Scalable Training Environment for Thinking with Medical Images via Tool-Integrated Reinforcement Learning](https://mlsanity.com/paper/2601.07107/) (2026)
- [Experience-Driven Multi-Agent Systems Are Training-free Context-aware Earth Observers](https://mlsanity.com/paper/2602.02559/) (2026)
- [OPGAgent: An Agent for Auditable Dental Panoramic X-ray Interpretation](https://mlsanity.com/paper/2603.00462/) (2026)
- [CARES: Collaborative Agentic Reasoning for Error Detection in Surgery](https://mlsanity.com/paper/2508.08764/) (2025)
- [Strong Reasoning Isn't Enough: Evaluating Evidence Elicitation in Interactive Diagnosis](https://mlsanity.com/paper/2601.19773/) (2026)
- [Joint Optimization of Reasoning and Dual-Memory for Self-Learning Diagnostic Agent](https://mlsanity.com/paper/2604.07269/) (2026)
- [OralAgent: Integrating Reasoning, Tools, and Knowledge for Interactive Dental Image Analysis](https://mlsanity.com/paper/2605.27378/) (2026)
- [MedCTA: A Benchmark for Clinical Tool Agents](https://mlsanity.com/paper/2606.11702/) (2026)
- [ClinFusion: A Vision-Centric Multimodal LLM System for Holistic Medical Understanding](https://mlsanity.com/paper/2607.24743/) (2026)
- [CardAIc-Agents: A Multimodal Framework with Hierarchical Adaptation for Cardiac Care Support](https://mlsanity.com/paper/2508.13256/) (2025)
- [MedScope: Incentivizing "Think with Videos" for Clinical Reasoning via Coarse-to-Fine Tool Calling](https://mlsanity.com/paper/2602.13332/) (2026)
- [Computational Pathology in the Era of Emerging Foundation and Agentic AI -- International Expert Perspectives on Clinical Integration and Translational Readiness](https://mlsanity.com/paper/2603.05884/) (2026)

## Abstract (arXiv)

In modern medicine, clinical diagnosis relies on the comprehensive analysis of primarily textual and visual data, drawing on medical expertise to ensure systematic and rigorous reasoning. Recent advances in large Vision-Language Models (VLMs) and agent-based methods hold great potential for medical diagnosis, thanks to the ability to effectively integrate multi-modal patient data. However, they often provide direct answers and draw empirical-driven conclusions without quantitative analysis, which reduces their reliability and clinical usability. We propose MedAgent-Pro, a new agentic reasoning paradigm that follows the diagnosis principle in modern medicine, to decouple the process into sequential components for step-by-step, evidence-based reasoning. Our MedAgent-Pro workflow presents a hierarchical diagnostic structure to mirror this principle, consisting of disease-level standardized plan generation and patient-level personalized step-by-step reasoning. To support disease-level planning, an RAG-based agent is designed to retrieve medical guidelines to ensure alignment with clinical standards. For patient-level reasoning, we propose to integrate professional tools such as visual models to enable quantitative assessments. Meanwhile, we propose to verify the reliability of each step to achieve evidence-based diagnosis, enforcing rigorous logical reasoning and a well-founded conclusion. Extensive experiments across a wide range of anatomical regions, imaging modalities, and diseases demonstrate the superiority of MedAgent-Pro to mainstream VLMs, agentic systems and state-of-the-art expert models. Ablation studies and human evaluation by clinical experts further validate its robustness and clinical relevance. Code is available at https://github.com/jinlab-imvr/MedAgent-Pro.