# ZECO: ZeroFusion Guided 3D MRI Conditional Generation

arXiv: https://arxiv.org/abs/2503.18246 · HTML: https://mlsanity.com/paper/2503.18246/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 22 of its 33 references that are in the map.
- First posted on arXiv 24 Mar 2025.

## Builds on (most cited first, 22 of 22)

- [Denoising Diffusion Probabilistic Models](https://mlsanity.com/paper/2006.11239/) (2020)
- [U-Net: Convolutional Networks for Biomedical Image Segmentation](https://mlsanity.com/paper/1505.04597/) (2015)
- [High-Resolution Image Synthesis with Latent Diffusion Models](https://mlsanity.com/paper/2112.10752/) (2021)
- [LoRA: Low-Rank Adaptation of Large Language Models](https://mlsanity.com/paper/2106.09685/) (2021)
- [Deep Unsupervised Learning using Nonequilibrium Thermodynamics](https://mlsanity.com/paper/1503.03585/) (2015)
- [Adding Conditional Control to Text-to-Image Diffusion Models](https://mlsanity.com/paper/2302.05543/) (2023)
- [DreamBooth: Fine Tuning Text-to-Image Diffusion Models for Subject-Driven Generation](https://mlsanity.com/paper/2208.12242/) (2022)
- [Brain Imaging Generation with Latent Diffusion Models](https://mlsanity.com/paper/2209.07162/) (2022)
- [Diffusion Models for Implicit Image Segmentation Ensembles](https://mlsanity.com/paper/2112.03145/) (2021)
- [MedSegDiff: Medical Image Segmentation with Diffusion Probabilistic Model](https://mlsanity.com/paper/2211.00611/) (2022)
- [MedGAN: Medical Image Translation using GANs](https://mlsanity.com/paper/1806.06397/) (2018)
- [Adaptive Diffusion Priors for Accelerated MRI Reconstruction](https://mlsanity.com/paper/2207.05876/) (2022)
- [Ambiguous Medical Image Segmentation using Diffusion Models](https://mlsanity.com/paper/2304.04745/) (2023)
- [Conversion Between CT and MRI Images Using Diffusion and Score-Matching Models](https://mlsanity.com/paper/2209.12104/) (2022)
- [Anatomically-Controllable Medical Image Generation with Segmentation-Guided Diffusion Models](https://mlsanity.com/paper/2402.05210/) (2024)
- [GANs for Medical Image Synthesis: An Empirical Study](https://mlsanity.com/paper/2105.05318/) (2021)
- [CoLa-Diff: Conditional Latent Diffusion Model for Multi-Modal MRI Synthesis](https://mlsanity.com/paper/2303.14081/) (2023)
- [Adaptive Latent Diffusion Model for 3D Medical Image to Image Translation: Multi-modal Magnetic Resonance Imaging Study](https://mlsanity.com/paper/2311.00265/) (2023)
- [Stabilizing Generative Adversarial Networks: A Survey](https://mlsanity.com/paper/1910.00927/) (2019)
- [QU-BraTS: MICCAI BraTS 2020 Challenge on Quantifying Uncertainty in Brain Tumor Segmentation - Analysis of Ranking Scores and Benchmarking Results](https://mlsanity.com/paper/2112.10074/) (2021)
- [Progressively Volumetrized Deep Generative Models for Data-Efficient Contextual Learning of MR Image Recovery](https://mlsanity.com/paper/2011.13913/) (2020)
- [Semantic Image Synthesis for Abdominal CT](https://mlsanity.com/paper/2312.06453/) (2023)

## Abstract (arXiv)

Medical image segmentation is crucial for enhancing diagnostic accuracy and treatment planning in Magnetic Resonance Imaging (MRI). However, acquiring precise lesion masks for segmentation model training demands specialized expertise and significant time investment, leading to a small dataset scale in clinical practice. In this paper, we present ZECO, a ZeroFusion guided 3D MRI conditional generation framework that extracts, compresses, and generates high-fidelity MRI images with corresponding 3D segmentation masks to mitigate data scarcity. To effectively capture inter-slice relationships within volumes, we introduce a Spatial Transformation Module that encodes MRI images into a compact latent space for the diffusion process. Moving beyond unconditional generation, our novel ZeroFusion method progressively maps 3D masks to MRI images in latent space, enabling robust training on limited datasets while avoiding overfitting. ZECO outperforms state-of-the-art models in both quantitative and qualitative evaluations on Brain MRI datasets across various modalities, showcasing its exceptional capability in synthesizing high-quality MRI images conditioned on segmentation masks.