# MedPlan: A Two-Stage RAG-Based System for Personalized Medical Plan Generation

arXiv: https://arxiv.org/abs/2503.17900 · HTML: https://mlsanity.com/paper/2503.17900/

## Key facts

- Cited by 5 papers in the map (data through 14 Oct 2026).
- Builds on 12 of its 40 references that are in the map.
- First posted on arXiv 23 Mar 2025.

## Builds on (most cited first, 12 of 12)

- [Retrieval-Augmented Generation for Knowledge-Intensive NLP Tasks](https://mlsanity.com/paper/2005.11401/) (2020)
- [BERTScore: Evaluating Text Generation with BERT](https://mlsanity.com/paper/1904.09675/) (2019)
- [Dense Passage Retrieval for Open-Domain Question Answering](https://mlsanity.com/paper/2004.04906/) (2020)
- [Passage Re-ranking with BERT](https://mlsanity.com/paper/1901.04085/) (2019)
- [An Analysis of Fusion Functions for Hybrid Retrieval](https://mlsanity.com/paper/2210.11934/) (2022)
- [MedicalAgentsBench for Complex Medical Reasoning: Comparing Internalized Reasoning Models versus Externalized Agent-based Frameworks](https://mlsanity.com/paper/2503.07459/) (2025)
- [Quantifying the Reasoning Abilities of LLMs on Real-world Clinical Cases](https://mlsanity.com/paper/2503.04691/) (2025)
- [Towards Resilient and Efficient LLMs: A Comparative Study of Efficiency, Performance, and Adversarial Robustness](https://mlsanity.com/paper/2408.04585/) (2024)
- [Automated radiotherapy treatment planning guided by GPT-4Vision](https://mlsanity.com/paper/2406.15609/) (2024)
- [Towards Conversational AI for Disease Management](https://mlsanity.com/paper/2503.06074/) (2025)
- [Multi-OphthaLingua: A Multilingual Benchmark for Assessing and Debiasing LLM Ophthalmological QA in LMICs](https://mlsanity.com/paper/2412.14304/) (2024)
- [MAP: Evaluation and Multi-Agent Enhancement of Large Language Models for Inpatient Pathways](https://mlsanity.com/paper/2503.13205/) (2025)

## Built on by (most cited first, 5 of 5)

- [Toward Personalized LLM-Powered Agents: Foundations, Evaluation, and Future Directions](https://mlsanity.com/paper/2602.22680/) (2026)
- [BudgetLeak: Membership Inference Attacks on RAG Systems via the Generation Budget Side Channel](https://mlsanity.com/paper/2511.12043/) (2025)
- [EHRNavigator: A Multi-Agent System for Patient-Level Clinical Question Answering over Heterogeneous Electronic Health Records](https://mlsanity.com/paper/2601.10020/) (2026)
- [CAREAgent: Clinical Agent with Structured Reasoning and Tool-Integrated for Order Generation](https://mlsanity.com/paper/2606.01094/) (2026)
- [ARMED: Adaptive Retrieval-Augmented Medication Recommendation](https://mlsanity.com/paper/2610.16440/) (2026)

## Abstract (arXiv)

Despite recent success in applying large language models (LLMs) to electronic health records (EHR), most systems focus primarily on assessment rather than treatment planning. We identify three critical limitations in current approaches: they generate treatment plans in a single pass rather than following the sequential reasoning process used by clinicians; they rarely incorporate patient-specific historical context; and they fail to effectively distinguish between subjective and objective clinical information. Motivated by the SOAP methodology (Subjective, Objective, Assessment, Plan), we introduce ours, a novel framework that structures LLM reasoning to align with real-life clinician workflows. Our approach employs a two-stage architecture that first generates a clinical assessment based on patient symptoms and objective data, then formulates a structured treatment plan informed by this assessment and enriched with patient-specific information through retrieval-augmented generation. Comprehensive evaluation demonstrates that our method significantly outperforms baseline approaches in both assessment accuracy and treatment plan quality.