# Cross-Modal Interactive Perception Network with Mamba for Lung Tumor Segmentation in PET-CT Images

arXiv: https://arxiv.org/abs/2503.17261 · HTML: https://mlsanity.com/paper/2503.17261/

## Key facts

- Cited by 3 papers in the map (data through 14 Oct 2026).
- Placed in Mamba for medical image analysis, one of 10 directions in State-space sequence models (S4, Mamba).
- Builds on 26 of its 46 references that are in the map.
- First posted on arXiv 21 Mar 2025.

## Placed in

- State-space sequence models (S4, Mamba) / [Mamba for medical image analysis](https://mlsanity.com/ssm/mamba-for-medical-image-analysis/)

## Builds on (most cited first, 26 of 26)

- [ImageNet Large Scale Visual Recognition Challenge](https://mlsanity.com/paper/1409.0575/) (2014)
- [Mamba: Linear-Time Sequence Modeling with Selective State Spaces](https://mlsanity.com/paper/2312.00752/) (2023)
- [Efficiently Modeling Long Sequences with Structured State Spaces](https://mlsanity.com/paper/2111.00396/) (2021)
- [TransUNet: Transformers Make Strong Encoders for Medical Image Segmentation](https://mlsanity.com/paper/2102.04306/) (2021)
- [Swin-Unet: Unet-like Pure Transformer for Medical Image Segmentation](https://mlsanity.com/paper/2105.05537/) (2021)
- [Vision Mamba: Efficient Visual Representation Learning with Bidirectional State Space Model](https://mlsanity.com/paper/2401.09417/) (2024)
- [Simplified State Space Layers for Sequence Modeling](https://mlsanity.com/paper/2208.04933/) (2022)
- [Combining Recurrent, Convolutional, and Continuous-time Models with Linear State-Space Layers](https://mlsanity.com/paper/2110.13985/) (2021)
- [U-Mamba: Enhancing Long-range Dependency for Biomedical Image Segmentation](https://mlsanity.com/paper/2401.04722/) (2024)
- [SegMamba: Long-range Sequential Modeling Mamba For 3D Medical Image Segmentation](https://mlsanity.com/paper/2401.13560/) (2024)
- [LocalMamba: Visual State Space Model with Windowed Selective Scan](https://mlsanity.com/paper/2403.09338/) (2024)
- [CMX: Cross-Modal Fusion for RGB-X Semantic Segmentation with Transformers](https://mlsanity.com/paper/2203.04838/) (2022)
- [Swin-UMamba: Mamba-based UNet with ImageNet-based pretraining](https://mlsanity.com/paper/2402.03302/) (2024)
- [Multimodal Token Fusion for Vision Transformers](https://mlsanity.com/paper/2204.08721/) (2022)
- [Delivering Arbitrary-Modal Semantic Segmentation](https://mlsanity.com/paper/2303.01480/) (2023)
- [Sigma: Siamese Mamba Network for Multi-Modal Semantic Segmentation](https://mlsanity.com/paper/2404.04256/) (2024)
- [DFormer: Rethinking RGBD Representation Learning for Semantic Segmentation](https://mlsanity.com/paper/2309.09668/) (2023)
- [LightM-UNet: Mamba Assists in Lightweight UNet for Medical Image Segmentation](https://mlsanity.com/paper/2403.05246/) (2024)
- [GeminiFusion: Efficient Pixel-wise Multimodal Fusion for Vision Transformer](https://mlsanity.com/paper/2406.01210/) (2024)
- [Weak-Mamba-UNet: Visual Mamba Makes CNN and ViT Work Better for Scribble-based Medical Image Segmentation](https://mlsanity.com/paper/2402.10887/) (2024)
- [Semi-Mamba-UNet: Pixel-Level Contrastive and Pixel-Level Cross-Supervised Visual Mamba-based UNet for Semi-Supervised Medical Image Segmentation](https://mlsanity.com/paper/2402.07245/) (2024)
- [Multimodal Spatial Attention Module for Targeting Multimodal PET-CT Lung Tumor Segmentation](https://mlsanity.com/paper/2007.14728/) (2020)
- [AsymFormer: Asymmetrical Cross-Modal Representation Learning for Mobile Platform Real-Time RGB-D Semantic Segmentation](https://mlsanity.com/paper/2309.14065/) (2023)
- [Co-Learning Feature Fusion Maps from PET-CT Images of Lung Cancer](https://mlsanity.com/paper/1810.02492/) (2018)
- [nnSAM: Plug-and-play Segment Anything Model Improves nnUNet Performance](https://mlsanity.com/paper/2309.16967/) (2023)
- [Channel Exchanging Networks for Multimodal and Multitask Dense Image Prediction](https://mlsanity.com/paper/2112.02252/) (2021)

## Built on by (most cited first, 3 of 3)

- [Context-Gated Cross-Modal Perception with Visual Mamba for PET-CT Lung Tumor Segmentation](https://mlsanity.com/paper/2510.27508/) (2025)
- [Multimodal Slice Interaction Network Enhanced by Transfer Learning for Precise Segmentation of Internal Gross Tumor Volume in Lung Cancer PET/CT Imaging](https://mlsanity.com/paper/2509.22841/) (2025)
- [CoMLP: Cooperatively-Gated MLPs for Fine-Grained Cross-Modal Information Fusion in Medical Image Segmentation](https://mlsanity.com/paper/2609.04781/) (2026)

## Abstract (arXiv)

Lung cancer is a leading cause of cancer-related deaths globally. PET-CT is crucial for imaging lung tumors, providing essential metabolic and anatomical information, while it faces challenges such as poor image quality, motion artifacts, and complex tumor morphology. Deep learning-based models are expected to address these problems, however, existing small-scale and private datasets limit significant performance improvements for these methods. Hence, we introduce a large-scale PET-CT lung tumor segmentation dataset, termed PCLT20K, which comprises 21,930 pairs of PET-CT images from 605 patients. Furthermore, we propose a cross-modal interactive perception network with Mamba (CIPA) for lung tumor segmentation in PET-CT images. Specifically, we design a channel-wise rectification module (CRM) that implements a channel state space block across multi-modal features to learn correlated representations and helps filter out modality-specific noise. A dynamic cross-modality interaction module (DCIM) is designed to effectively integrate position and context information, which employs PET images to learn regional position information and serves as a bridge to assist in modeling the relationships between local features of CT images. Extensive experiments on a comprehensive benchmark demonstrate the effectiveness of our CIPA compared to the current state-of-the-art segmentation methods. We hope our research can provide more exploration opportunities for medical image segmentation. The dataset and code are available at https://github.com/mj129/CIPA.