# Enhancing LLM Generation with Knowledge Hypergraph for Evidence-Based Medicine

arXiv: https://arxiv.org/abs/2503.16530 · HTML: https://mlsanity.com/paper/2503.16530/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 17 of its 33 references that are in the map.
- First posted on arXiv 18 Mar 2025.

## Builds on (most cited first, 17 of 17)

- [Retrieval-Augmented Generation for Knowledge-Intensive NLP Tasks](https://mlsanity.com/paper/2005.11401/) (2020)
- [Sentence-BERT: Sentence Embeddings using Siamese BERT-Networks](https://mlsanity.com/paper/1908.10084/) (2019)
- [Retrieval-Augmented Generation for Large Language Models: A Survey](https://mlsanity.com/paper/2312.10997/) (2023)
- [From Local to Global: A Graph RAG Approach to Query-Focused Summarization](https://mlsanity.com/paper/2404.16130/) (2024)
- [What Disease does this Patient Have? A Large-scale Open Domain Question Answering Dataset from Medical Exams](https://mlsanity.com/paper/2009.13081/) (2020)
- [In-Context Retrieval-Augmented Language Models](https://mlsanity.com/paper/2302.00083/) (2023)
- [Precise Zero-Shot Dense Retrieval without Relevance Labels](https://mlsanity.com/paper/2212.10496/) (2022)
- [Enhancing Retrieval-Augmented Large Language Models with Iterative Retrieval-Generation Synergy](https://mlsanity.com/paper/2305.15294/) (2023)
- [Graph Retrieval-Augmented Generation: A Survey](https://mlsanity.com/paper/2408.08921/) (2024)
- [Retrieval-Augmented Generation with Knowledge Graphs for Customer Service Question Answering](https://mlsanity.com/paper/2404.17723/) (2024)
- [HybridRAG: Integrating Knowledge Graphs and Vector Retrieval Augmented Generation for Efficient Information Extraction](https://mlsanity.com/paper/2408.04948/) (2024)
- [Medical Graph RAG: Towards Safe Medical Large Language Model via Graph Retrieval-Augmented Generation](https://mlsanity.com/paper/2408.04187/) (2024)
- [Plan-on-Graph: Self-Correcting Adaptive Planning of Large Language Model on Knowledge Graphs](https://mlsanity.com/paper/2410.23875/) (2024)
- [Graph Reasoning for Question Answering with Triplet Retrieval](https://mlsanity.com/paper/2305.18742/) (2023)
- [BlendFilter: Advancing Retrieval-Augmented Large Language Models via Query Generation Blending and Knowledge Filtering](https://mlsanity.com/paper/2402.11129/) (2024)
- [TC-RAG:Turing-Complete RAG's Case study on Medical LLM Systems](https://mlsanity.com/paper/2408.09199/) (2024)
- [Graphusion: A RAG Framework for Knowledge Graph Construction with a Global Perspective](https://mlsanity.com/paper/2410.17600/) (2024)

## Abstract (arXiv)

Evidence-based medicine (EBM) plays a crucial role in the application of large language models (LLMs) in healthcare, as it provides reliable support for medical decision-making processes. Although it benefits from current retrieval-augmented generation~(RAG) technologies, it still faces two significant challenges: the collection of dispersed evidence and the efficient organization of this evidence to support the complex queries necessary for EBM. To tackle these issues, we propose using LLMs to gather scattered evidence from multiple sources and present a knowledge hypergraph-based evidence management model to integrate these evidence while capturing intricate relationships. Furthermore, to better support complex queries, we have developed an Importance-Driven Evidence Prioritization (IDEP) algorithm that utilizes the LLM to generate multiple evidence features, each with an associated importance score, which are then used to rank the evidence and produce the final retrieval results. Experimental results from six datasets demonstrate that our approach outperforms existing RAG techniques in application domains of interest to EBM, such as medical quizzing, hallucination detection, and decision support. Testsets and the constructed knowledge graph can be accessed at hrefhttps://drive.google.com/file/d/1WJ9QTokK3MdkjEmwuFQxwH96jByawj_/view?usp=drivelinkhttps://drive.google.com/rag4ebm.