# FedSCA: Federated Tuning with Similarity-guided Collaborative Aggregation for Heterogeneous Medical Image Segmentation

arXiv: https://arxiv.org/abs/2503.15390 · HTML: https://mlsanity.com/paper/2503.15390/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 41 of its 49 references that are in the map.
- First posted on arXiv 19 Mar 2025.

## Builds on (most cited first, 30 of 41)

- [Learning Transferable Visual Models From Natural Language Supervision](https://mlsanity.com/paper/2103.00020/) (2021)
- [Denoising Diffusion Probabilistic Models](https://mlsanity.com/paper/2006.11239/) (2020)
- [U-Net: Convolutional Networks for Biomedical Image Segmentation](https://mlsanity.com/paper/1505.04597/) (2015)
- [Segment Anything](https://mlsanity.com/paper/2304.02643/) (2023)
- [Communication-Efficient Learning of Deep Networks from Decentralized Data](https://mlsanity.com/paper/1602.05629/) (2016)
- [End-to-End Object Detection with Transformers](https://mlsanity.com/paper/2005.12872/) (2020)
- [Masked Autoencoders Are Scalable Vision Learners](https://mlsanity.com/paper/2111.06377/) (2021)
- [Parameter-Efficient Transfer Learning for NLP](https://mlsanity.com/paper/1902.00751/) (2019)
- [Federated Optimization in Heterogeneous Networks](https://mlsanity.com/paper/1812.06127/) (2018)
- [V-Net: Fully Convolutional Neural Networks for Volumetric Medical Image Segmentation](https://mlsanity.com/paper/1606.04797/) (2016)
- [TransUNet: Transformers Make Strong Encoders for Medical Image Segmentation](https://mlsanity.com/paper/2102.04306/) (2021)
- [Attention U-Net: Learning Where to Look for the Pancreas](https://mlsanity.com/paper/1804.03999/) (2018)
- [Swin-Unet: Unet-like Pure Transformer for Medical Image Segmentation](https://mlsanity.com/paper/2105.05537/) (2021)
- [AdapterFusion: Non-Destructive Task Composition for Transfer Learning](https://mlsanity.com/paper/2005.00247/) (2020)
- [CVXPY: A Python-Embedded Modeling Language for Convex Optimization](https://mlsanity.com/paper/1603.00943/) (2016)
- [The Future of Digital Health with Federated Learning](https://mlsanity.com/paper/2003.08119/) (2020)
- [Medical SAM Adapter: Adapting Segment Anything Model for Medical Image Segmentation](https://mlsanity.com/paper/2304.12620/) (2023)
- [Flower: A Friendly Federated Learning Research Framework](https://mlsanity.com/paper/2007.14390/) (2020)
- [Road Extraction by Deep Residual U-Net](https://mlsanity.com/paper/1711.10684/) (2017)
- [UNet 3+: A Full-Scale Connected UNet for Medical Image Segmentation](https://mlsanity.com/paper/2004.08790/) (2020)
- [FedDG: Federated Domain Generalization on Medical Image Segmentation via Episodic Learning in Continuous Frequency Space](https://mlsanity.com/paper/2103.06030/) (2021)
- [No Fear of Heterogeneity: Classifier Calibration for Federated Learning with Non-IID Data](https://mlsanity.com/paper/2106.05001/) (2021)
- [A Rewriting System for Convex Optimization Problems](https://mlsanity.com/paper/1709.04494/) (2017)
- [FederatedScope-LLM: A Comprehensive Package for Fine-tuning Large Language Models in Federated Learning](https://mlsanity.com/paper/2309.00363/) (2023)
- [MedSegDiff-V2: Diffusion based Medical Image Segmentation with Transformer](https://mlsanity.com/paper/2301.11798/) (2023)
- [FedPrompt: Communication-Efficient and Privacy Preserving Prompt Tuning in Federated Learning](https://mlsanity.com/paper/2208.12268/) (2022)
- [When Foundation Model Meets Federated Learning: Motivations, Challenges, and Future Directions](https://mlsanity.com/paper/2306.15546/) (2023)
- [Selective Aggregation for Low-Rank Adaptation in Federated Learning](https://mlsanity.com/paper/2410.01463/) (2024)
- [Closing the Generalization Gap of Cross-silo Federated Medical Image Segmentation](https://mlsanity.com/paper/2203.10144/) (2022)
- [Eliminating Domain Bias for Federated Learning in Representation Space](https://mlsanity.com/paper/2311.14975/) (2023)

## Abstract (arXiv)

Transformer-based foundation models (FMs) have recently demonstrated remarkable performance in medical image segmentation. However, scaling these models is challenging due to the limited size of medical image datasets within isolated hospitals, where data centralization is restricted due to privacy concerns. These constraints, combined with the data-intensive nature of FMs, hinder their broader application. Integrating federated learning (FL) with foundation models (FLFM) fine-tuning offers a potential solution to these challenges by enabling collaborative model training without data sharing, thus allowing FMs to take advantage of a diverse pool of sensitive medical image data across hospitals/clients. However, non-independent and identically distributed (non-IID) data among clients, paired with computational and communication constraints in federated environments, presents an additional challenge that limits further performance improvements and remains inadequately addressed in existing studies. In this work, we propose a novel FLFM fine-tuning framework, underlineFederated tuning with underlineSimilarity-guided underlineCollaborative underlineAggregation (FedSCA), encompassing all phases of the FL process. This includes (1) specially designed parameter-efficient fine-tuning (PEFT) for local client training to enhance computational efficiency; (2) partial low-level adapter transmission for communication efficiency; and (3) similarity-guided collaborative aggregation (SGCA) on the server side to address non-IID issues. Extensive experiments on three FL benchmarks for medical image segmentation demonstrate the effectiveness of our proposed FedSCA, establishing new SOTA performance.