# Generating Medically-Informed Explanations for Depression Detection using LLMs

arXiv: https://arxiv.org/abs/2503.14671 · HTML: https://mlsanity.com/paper/2503.14671/

## Key facts

- Cited by 1 papers in the map (data through 14 Oct 2026).
- Builds on 12 of its 23 references that are in the map.
- First posted on arXiv 18 Mar 2025.

## Builds on (most cited first, 12 of 12)

- [BERT: Pre-training of Deep Bidirectional Transformers for Language Understanding](https://mlsanity.com/paper/1810.04805/) (2018)
- [Scaling Laws for Neural Language Models](https://mlsanity.com/paper/2001.08361/) (2020)
- [Training Compute-Optimal Large Language Models](https://mlsanity.com/paper/2203.15556/) (2022)
- [Visual In-Context Learning for Large Vision-Language Models](https://mlsanity.com/paper/2402.11574/) (2024)
- [Language Models with Image Descriptors are Strong Few-Shot Video-Language Learners](https://mlsanity.com/paper/2205.10747/) (2022)
- [Improving Medical Large Vision-Language Models with Abnormal-Aware Feedback](https://mlsanity.com/paper/2501.01377/) (2025)
- [A Survey on Large Language Models with Multilingualism: Recent Advances and New Frontiers](https://mlsanity.com/paper/2405.10936/) (2024)
- [EmoBench-M: Benchmarking Emotional Intelligence for Multimodal Large Language Models](https://mlsanity.com/paper/2502.04424/) (2025)
- [Towards Trustworthy Retrieval Augmented Generation for Large Language Models: A Survey](https://mlsanity.com/paper/2502.06872/) (2025)
- [The Shaky Foundations of Clinical Foundation Models: A Survey of Large Language Models and Foundation Models for EMRs](https://mlsanity.com/paper/2303.12961/) (2023)
- [Multimodal Event Transformer for Image-guided Story Ending Generation](https://mlsanity.com/paper/2301.11357/) (2023)
- [Lost in the Source Language: How Large Language Models Evaluate the Quality of Machine Translation](https://mlsanity.com/paper/2401.06568/) (2024)

## Built on by (most cited first, 1 of 1)

- [Menta: A Small Language Model for On-Device Mental Health Prediction](https://mlsanity.com/paper/2512.02716/) (2025)

## Abstract (arXiv)

Early detection of depression from social media data offers a valuable opportunity for timely intervention. However, this task poses significant challenges, requiring both professional medical knowledge and the development of accurate and explainable models. In this paper, we propose LLM-MTD (Large Language Model for Multi-Task Depression Detection), a novel approach that leverages a pre-trained large language model to simultaneously classify social media posts for depression and generate textual explanations grounded in medical diagnostic criteria. We train our model using a multi-task learning framework with a combined loss function that optimizes both classification accuracy and explanation quality. We evaluate LLM-MTD on the benchmark Reddit Self-Reported Depression Dataset (RSDD) and compare its performance against several competitive baseline methods, including traditional machine learning and fine-tuned BERT. Our experimental results demonstrate that LLM-MTD achieves state-of-the-art performance in depression detection, showing significant improvements in AUPRC and other key metrics. Furthermore, human evaluation of the generated explanations reveals their relevance, completeness, and medical accuracy, highlighting the enhanced interpretability of our approach. This work contributes a novel methodology for depression detection that combines the power of large language models with the crucial aspect of explainability.