# Enhancing zero-shot learning in medical imaging: integrating clip with advanced techniques for improved chest x-ray analysis

arXiv: https://arxiv.org/abs/2503.13134 · HTML: https://mlsanity.com/paper/2503.13134/

## Key facts

- Cited by 2 papers in the map (data through 14 Oct 2026).
- Builds on 4 of its 6 references that are in the map.
- First posted on arXiv 17 Mar 2025.

## Builds on (most cited first, 4 of 4)

- [Learning Transferable Visual Models From Natural Language Supervision](https://mlsanity.com/paper/2103.00020/) (2021)
- [Momentum Contrast for Unsupervised Visual Representation Learning](https://mlsanity.com/paper/1911.05722/) (2019)
- [CheXpert: A Large Chest Radiograph Dataset with Uncertainty Labels and Expert Comparison](https://mlsanity.com/paper/1901.07031/) (2019)
- [ChestX-ray8: Hospital-scale Chest X-ray Database and Benchmarks on Weakly-Supervised Classification and Localization of Common Thorax Diseases](https://mlsanity.com/paper/1705.02315/) (2017)

## Built on by (most cited first, 2 of 2)

- [Advances and Challenges in Foundation Agents: From Brain-Inspired Intelligence to Evolutionary, Collaborative, and Safe Systems](https://mlsanity.com/paper/2504.01990/) (2025)
- [Benchmark Success, Clinical Failure: When Reinforcement Learning Optimizes for Benchmarks, Not Patients](https://mlsanity.com/paper/2512.23090/) (2025)

## Abstract (arXiv)

Due to the large volume of medical imaging data, advanced AI methodologies are needed to assist radiologists in diagnosing thoracic diseases from chest X-rays (CXRs). Existing deep learning models often require large, labeled datasets, which are scarce in medical imaging due to the time-consuming and expert-driven annotation process. In this paper, we extend the existing approach to enhance zero-shot learning in medical imaging by integrating Contrastive Language-Image Pre-training (CLIP) with Momentum Contrast (MoCo), resulting in our proposed model, MoCoCLIP. Our method addresses challenges posed by class-imbalanced and unlabeled datasets, enabling improved detection of pulmonary pathologies. Experimental results on the NIH ChestXray14 dataset demonstrate that MoCoCLIP outperforms the state-of-the-art CheXZero model, achieving relative improvement of approximately 6.5%. Furthermore, on the CheXpert dataset, MoCoCLIP demonstrates superior zero-shot performance, achieving an average AUC of 0.750 compared to CheXZero with 0.746 AUC, highlighting its enhanced generalization capabilities on unseen data.