# Pairwise Similarity Regularization for Semi-supervised Graph Medical Image Segmentation

arXiv: https://arxiv.org/abs/2503.12800 · HTML: https://mlsanity.com/paper/2503.12800/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 25 of its 38 references that are in the map.
- First posted on arXiv 17 Mar 2025.

## Builds on (most cited first, 25 of 25)

- [Adam: A Method for Stochastic Optimization](https://mlsanity.com/paper/1412.6980/) (2014)
- [U-Net: Convolutional Networks for Biomedical Image Segmentation](https://mlsanity.com/paper/1505.04597/) (2015)
- [V-Net: Fully Convolutional Neural Networks for Volumetric Medical Image Segmentation](https://mlsanity.com/paper/1606.04797/) (2016)
- [Uncertainty-aware Self-ensembling Model for Semi-supervised 3D Left Atrium Segmentation](https://mlsanity.com/paper/1907.07034/) (2019)
- [Semi-supervised Medical Image Segmentation through Dual-task Consistency](https://mlsanity.com/paper/2009.04448/) (2020)
- [Inf-Net: Automatic COVID-19 Lung Infection Segmentation from CT Images](https://mlsanity.com/paper/2004.14133/) (2020)
- [DeepOrgan: Multi-level Deep Convolutional Networks for Automated Pancreas Segmentation](https://mlsanity.com/paper/1506.06448/) (2015)
- [Shape-aware Semi-supervised 3D Semantic Segmentation for Medical Images](https://mlsanity.com/paper/2007.10732/) (2020)
- [Unsupervised Bidirectional Cross-Modality Adaptation via Deeply Synergistic Image and Feature Alignment for Medical Image Segmentation](https://mlsanity.com/paper/2002.02255/) (2020)
- [Bidirectional Copy-Paste for Semi-Supervised Medical Image Segmentation](https://mlsanity.com/paper/2305.00673/) (2023)
- [Semi-supervised Left Atrium Segmentation with Mutual Consistency Training](https://mlsanity.com/paper/2103.02911/) (2021)
- [Exploring Smoothness and Class-Separation for Semi-supervised Medical Image Segmentation](https://mlsanity.com/paper/2203.01324/) (2022)
- [Uncertainty-aware multi-view co-training for semi-supervised medical image segmentation and domain adaptation](https://mlsanity.com/paper/2006.16806/) (2020)
- [FaPN: Feature-aligned Pyramid Network for Dense Image Prediction](https://mlsanity.com/paper/2108.07058/) (2021)
- [Inconsistency-aware Uncertainty Estimation for Semi-supervised Medical Image Segmentation](https://mlsanity.com/paper/2110.08762/) (2021)
- [Semi-Supervised Learning by Augmented Distribution Alignment](https://mlsanity.com/paper/1905.08171/) (2019)
- [Directional Connectivity-based Segmentation of Medical Images](https://mlsanity.com/paper/2304.00145/) (2023)
- [Pseudo-label refinement using superpixels for semi-supervised brain tumour segmentation](https://mlsanity.com/paper/2110.08589/) (2021)
- [Robust Attributed Graph Alignment via Joint Structure Learning and Optimal Transport](https://mlsanity.com/paper/2301.12721/) (2023)
- [Source-Free Domain Adaptation for Medical Image Segmentation via Prototype-Anchored Feature Alignment and Contrastive Learning](https://mlsanity.com/paper/2307.09769/) (2023)
- [Compete to Win: Enhancing Pseudo Labels for Barely-supervised Medical Image Segmentation](https://mlsanity.com/paper/2304.07519/) (2023)
- [GraphCL: Graph-based Clustering for Semi-Supervised Medical Image Segmentation](https://mlsanity.com/paper/2411.13147/) (2024)
- [BSAFusion: A Bidirectional Stepwise Feature Alignment Network for Unaligned Medical Image Fusion](https://mlsanity.com/paper/2412.08050/) (2024)
- [Multi-Scale Cross Contrastive Learning for Semi-Supervised Medical Image Segmentation](https://mlsanity.com/paper/2306.14293/) (2023)
- [Graph Domain Adaptation with Localized Graph Signal Representations](https://mlsanity.com/paper/1911.02883/) (2019)

## Abstract (arXiv)

With fully leveraging the value of unlabeled data, semi-supervised medical image segmentation algorithms significantly reduces the limitation of limited labeled data, achieving a significant improvement in accuracy. However, the distributional shift between labeled and unlabeled data weakens the utilization of information from the labeled data. To alleviate the problem, we propose a graph network feature alignment method based on pairwise similarity regularization (PaSR) for semi-supervised medical image segmentation. PaSR aligns the graph structure of images in different domains by maintaining consistency in the pairwise structural similarity of feature graphs between the target domain and the source domain, reducing distribution shift issues in medical images. Meanwhile, further improving the accuracy of pseudo-labels in the teacher network by aligning graph clustering information to enhance the semi-supervised efficiency of the model. The experimental part was verified on three medical image segmentation benchmark datasets, with results showing improvements over advanced methods in various metrics. On the ACDC dataset, it achieved an average improvement of more than 10.66%.