# A Survey on the Optimization of Large Language Model-based Agents

arXiv: https://arxiv.org/abs/2503.12434 · HTML: https://mlsanity.com/paper/2503.12434/

## Key facts

- Cited by 46 papers in the map (data through 14 Oct 2026).
- Placed in General LLM agent frameworks and benchmarks, one of 16 directions in LLM agents and tool use.
- Builds on 181 of its 241 references that are in the map.
- First posted on arXiv 16 Mar 2025.

## Placed in

- LLM agents and tool use / [General LLM agent frameworks and benchmarks](https://mlsanity.com/agents/general-llm-agent-frameworks-and-benchmarks/)

## Builds on (most cited first, 30 of 181)

- [Training language models to follow instructions with human feedback](https://mlsanity.com/paper/2203.02155/) (2022)
- [Proximal Policy Optimization Algorithms](https://mlsanity.com/paper/1707.06347/) (2017)
- [RoBERTa: A Robustly Optimized BERT Pretraining Approach](https://mlsanity.com/paper/1907.11692/) (2019)
- [Training Verifiers to Solve Math Word Problems](https://mlsanity.com/paper/2110.14168/) (2021)
- [ReAct: Synergizing Reasoning and Acting in Language Models](https://mlsanity.com/paper/2210.03629/) (2022)
- [Judging LLM-as-a-Judge with MT-Bench and Chatbot Arena](https://mlsanity.com/paper/2306.05685/) (2023)
- [Evaluating Large Language Models Trained on Code](https://mlsanity.com/paper/2107.03374/) (2021)
- [Direct Preference Optimization: Your Language Model is Secretly a Reward Model](https://mlsanity.com/paper/2305.18290/) (2023)
- [Measuring Massive Multitask Language Understanding](https://mlsanity.com/paper/2009.03300/) (2020)
- [Measuring Mathematical Problem Solving With the MATH Dataset](https://mlsanity.com/paper/2103.03874/) (2021)
- [Think you have Solved Question Answering? Try ARC, the AI2 Reasoning Challenge](https://mlsanity.com/paper/1803.05457/) (2018)
- [Reflexion: Language Agents with Verbal Reinforcement Learning](https://mlsanity.com/paper/2303.11366/) (2023)
- [HotpotQA: A Dataset for Diverse, Explainable Multi-hop Question Answering](https://mlsanity.com/paper/1809.09600/) (2018)
- [QLoRA: Efficient Finetuning of Quantized LLMs](https://mlsanity.com/paper/2305.14314/) (2023)
- [TruthfulQA: Measuring How Models Mimic Human Falsehoods](https://mlsanity.com/paper/2109.07958/) (2021)
- [TriviaQA: A Large Scale Distantly Supervised Challenge Dataset for Reading Comprehension](https://mlsanity.com/paper/1705.03551/) (2017)
- [VQA: Visual Question Answering](https://mlsanity.com/paper/1505.00468/) (2015)
- [Do As I Can, Not As I Say: Grounding Language in Robotic Affordances](https://mlsanity.com/paper/2204.01691/) (2022)
- [Voyager: An Open-Ended Embodied Agent with Large Language Models](https://mlsanity.com/paper/2305.16291/) (2023)
- [WebArena: A Realistic Web Environment for Building Autonomous Agents](https://mlsanity.com/paper/2307.13854/) (2023)
- [LiveCodeBench: Holistic and Contamination Free Evaluation of Large Language Models for Code](https://mlsanity.com/paper/2403.07974/) (2024)
- [AutoGen: Enabling Next-Gen LLM Applications via Multi-Agent Conversation](https://mlsanity.com/paper/2308.08155/) (2023)
- [ToolLLM: Facilitating Large Language Models to Master 16000+ Real-world APIs](https://mlsanity.com/paper/2307.16789/) (2023)
- [Learn to Explain: Multimodal Reasoning via Thought Chains for Science Question Answering](https://mlsanity.com/paper/2209.09513/) (2022)
- [Self-RAG: Learning to Retrieve, Generate, and Critique through Self-Reflection](https://mlsanity.com/paper/2310.11511/) (2023)
- [Large Language Models Encode Clinical Knowledge](https://mlsanity.com/paper/2212.13138/) (2022)
- [SWE-agent: Agent-Computer Interfaces Enable Automated Software Engineering](https://mlsanity.com/paper/2405.15793/) (2024)
- [The Rise and Potential of Large Language Model Based Agents: A Survey](https://mlsanity.com/paper/2309.07864/) (2023)
- [CAMEL: Communicative Agents for "Mind" Exploration of Large Language Model Society](https://mlsanity.com/paper/2303.17760/) (2023)
- [PubMedQA: A Dataset for Biomedical Research Question Answering](https://mlsanity.com/paper/1909.06146/) (2019)

## Built on by (most cited first, 30 of 46)

- [A Survey of Context Engineering for Large Language Models](https://mlsanity.com/paper/2507.13334/) (2025)
- [Long-Horizon-Terminal-Bench: Testing the Limits of Agents on Long-Horizon Terminal Tasks with Dense Reward-Based Grading](https://mlsanity.com/paper/2607.08964/) (2026)
- [MLEvolve: A Self-Evolving Framework for Automated Machine Learning Algorithm Discovery](https://mlsanity.com/paper/2606.06473/) (2026)
- [From Static Templates to Dynamic Runtime Graphs: A Survey of Workflow Optimization for LLM Agents](https://mlsanity.com/paper/2603.22386/) (2026)
- [Recursive Synthesis for Long-Horizon Terminal Tasks](https://mlsanity.com/paper/2608.05466/) (2026)
- [Coarse-to-Fine Grounded Memory for LLM Agent Planning](https://mlsanity.com/paper/2508.15305/) (2025)
- [OEP: Poisoning Self-Evolving LLM Agents via Locally Correct but Non-Transferable Experiences](https://mlsanity.com/paper/2605.18930/) (2026)
- [APTBench: Benchmarking Agentic Potential of Base LLMs During Pre-Training](https://mlsanity.com/paper/2510.24397/) (2025)
- [A Call for Collaborative Intelligence: Why Human-Agent Systems Should Precede AI Autonomy](https://mlsanity.com/paper/2506.09420/) (2025)
- [RealFactBench: A Benchmark for Evaluating Large Language Models in Real-World Fact-Checking](https://mlsanity.com/paper/2506.12538/) (2025)
- [SAC-Opt: Semantic Anchors for Iterative Correction in Optimization Modeling](https://mlsanity.com/paper/2510.05115/) (2025)
- [RMoA: Optimizing Mixture-of-Agents through Diversity Maximization and Residual Compensation](https://mlsanity.com/paper/2505.24442/) (2025)
- [Large Language Models Reasoning Abilities Under Non-Ideal Conditions After RL-Fine-Tuning](https://mlsanity.com/paper/2508.04848/) (2025)
- [AutoEDA: Enabling EDA Flow Automation through Microservice-Based LLM Agents](https://mlsanity.com/paper/2508.01012/) (2025)
- [What Do Agents Learn from Trajectory-SFT: Semantics or Interfaces?](https://mlsanity.com/paper/2602.01611/) (2026)
- [Embracing Trustworthy Brain-Agent Collaboration as Paradigm Extension for Intelligent Assistive Technologies](https://mlsanity.com/paper/2510.22095/) (2025)
- [AgentSPEX: An Agent SPecification and EXecution Language](https://mlsanity.com/paper/2604.13346/) (2026)
- [Collective Hallucination in Multi-Agent LLMs:Modeling and Defense](https://mlsanity.com/paper/2606.07941/) (2026)
- [Seeing Is Not Screening: Multimodal Hidden Instruction Attacks on Agent Skill Scanners](https://mlsanity.com/paper/2606.18198/) (2026)
- [Self-Evolving LLMs via Continual Instruction Tuning](https://mlsanity.com/paper/2509.18133/) (2025)
- [ColluSkill: Adversarial Cross-Skill Composition for Evading Agent Skill Scanners](https://mlsanity.com/paper/2608.09732/) (2026)
- [Auditing Harness Tampering in Self-Improving Agents](https://mlsanity.com/paper/2609.00069/) (2026)
- [MapCoder-Lite: Distilling Multi-Agent Coding into a Single Small LLM](https://mlsanity.com/paper/2509.17489/) (2025)
- [Supervised Fine-Tuning versus Reinforcement Learning: A Study of Post-Training Methods for Large Language Models](https://mlsanity.com/paper/2603.13985/) (2026)
- [Zero-Mem: Zero-Token Memory Operations for LLM Agents](https://mlsanity.com/paper/2607.29377/) (2026)
- [Reasoning Like an Economist: Post-Training on Economic Problems Induces Strategic Generalization in LLMs](https://mlsanity.com/paper/2506.00577/) (2025)
- [Cost and Accuracy of Long-Term Memory in Distributed Multi-Agent Systems Based on Large Language Models](https://mlsanity.com/paper/2601.07978/) (2026)
- [Plausibility as Failure: How LLMs and Humans Co-Construct Epistemic Error](https://mlsanity.com/paper/2512.16750/) (2025)
- [MARO: Learning Stronger Reasoning from Social Interaction](https://mlsanity.com/paper/2601.12323/) (2026)
- [Lemon Agent Technical Report](https://mlsanity.com/paper/2602.07092/) (2026)

## Abstract (arXiv)

With the rapid development of Large Language Models (LLMs), LLM-based agents have been widely adopted in various fields, becoming essential for autonomous decision-making and interactive tasks. However, current work typically relies on prompt design or fine-tuning strategies applied to vanilla LLMs, which often leads to limited effectiveness or suboptimal performance in complex agent-related environments. Although LLM optimization techniques can improve model performance across many general tasks, they lack specialized optimization towards critical agent functionalities such as long-term planning, dynamic environmental interaction, and complex decision-making. Although numerous recent studies have explored various strategies to optimize LLM-based agents for complex agent tasks, a systematic review summarizing and comparing these methods from a holistic perspective is still lacking. In this survey, we provide a comprehensive review of LLM-based agent optimization approaches, categorizing them into parameter-driven and parameter-free methods. We first focus on parameter-driven optimization, covering fine-tuning-based optimization, reinforcement learning-based optimization, and hybrid strategies, analyzing key aspects such as trajectory data construction, fine-tuning techniques, reward function design, and optimization algorithms. Additionally, we briefly discuss parameter-free strategies that optimize agent behavior through prompt engineering and external knowledge retrieval. Finally, we summarize the datasets and benchmarks used for evaluation and tuning, review key applications of LLM-based agents, and discuss major challenges and promising future directions. Our repository for related references is available at https://github.com/YoungDubbyDu/LLM-Agent-Optimization.