# Minding Fuzzy Regions: A Data-driven Alternating Learning Paradigm for Stable Lesion Segmentation

arXiv: https://arxiv.org/abs/2503.11140 · HTML: https://mlsanity.com/paper/2503.11140/

## Key facts

- Cited by 1 papers in the map (data through 14 Oct 2026).
- Builds on 29 of its 48 references that are in the map.
- First posted on arXiv 14 Mar 2025.

## Builds on (most cited first, 29 of 29)

- [Adam: A Method for Stochastic Optimization](https://mlsanity.com/paper/1412.6980/) (2014)
- [PyTorch: An Imperative Style, High-Performance Deep Learning Library](https://mlsanity.com/paper/1912.01703/) (2019)
- [U-Net: Convolutional Networks for Biomedical Image Segmentation](https://mlsanity.com/paper/1505.04597/) (2015)
- [SAM 2: Segment Anything in Images and Videos](https://mlsanity.com/paper/2408.00714/) (2024)
- [TransUNet: Transformers Make Strong Encoders for Medical Image Segmentation](https://mlsanity.com/paper/2102.04306/) (2021)
- [UNet++: A Nested U-Net Architecture for Medical Image Segmentation](https://mlsanity.com/paper/1807.10165/) (2018)
- [Generalized Cross Entropy Loss for Training Deep Neural Networks with Noisy Labels](https://mlsanity.com/paper/1805.07836/) (2018)
- [MentorNet: Learning Data-Driven Curriculum for Very Deep Neural Networks on Corrupted Labels](https://mlsanity.com/paper/1712.05055/) (2017)
- [Kvasir-SEG: A Segmented Polyp Dataset](https://mlsanity.com/paper/1911.07069/) (2019)
- [PraNet: Parallel Reverse Attention Network for Polyp Segmentation](https://mlsanity.com/paper/2006.11392/) (2020)
- [Early-Learning Regularization Prevents Memorization of Noisy Labels](https://mlsanity.com/paper/2007.00151/) (2020)
- [How does Disagreement Help Generalization against Label Corruption?](https://mlsanity.com/paper/1901.04215/) (2019)
- [Meta Pseudo Labels](https://mlsanity.com/paper/2003.10580/) (2020)
- [A Benchmark for Endoluminal Scene Segmentation of Colonoscopy Images](https://mlsanity.com/paper/1612.00799/) (2016)
- [Skin Lesion Analysis toward Melanoma Detection: A Challenge at the International Symposium on Biomedical Imaging (ISBI) 2016, hosted by the International Skin Imaging Collaboration (ISIC)](https://mlsanity.com/paper/1605.01397/) (2016)
- [Swin-UMamba: Mamba-based UNet with ImageNet-based pretraining](https://mlsanity.com/paper/2402.03302/) (2024)
- [Medical SAM 2: Segment medical images as video via Segment Anything Model 2](https://mlsanity.com/paper/2408.00874/) (2024)
- [MosMedData: Chest CT Scans With COVID-19 Related Findings Dataset](https://mlsanity.com/paper/2005.06465/) (2020)
- [EMCAD: Efficient Multi-scale Convolutional Attention Decoding for Medical Image Segmentation](https://mlsanity.com/paper/2405.06880/) (2024)
- [Adaptive Early-Learning Correction for Segmentation from Noisy Annotations](https://mlsanity.com/paper/2110.03740/) (2021)
- [EGE-UNet: an Efficient Group Enhanced UNet for skin lesion segmentation](https://mlsanity.com/paper/2307.08473/) (2023)
- [AAU-net: An Adaptive Attention U-net for Breast Lesions Segmentation in Ultrasound Images](https://mlsanity.com/paper/2204.12077/) (2022)
- [Learning to Purify Noisy Labels via Meta Soft Label Corrector](https://mlsanity.com/paper/2008.00627/) (2020)
- [Ariadne's Thread:Using Text Prompts to Improve Segmentation of Infected Areas from Chest X-ray images](https://mlsanity.com/paper/2307.03942/) (2023)
- [When Noisy Labels Meet Long Tail Dilemmas: A Representation Calibration Method](https://mlsanity.com/paper/2211.10955/) (2022)
- [Label-Aware Distribution Calibration for Long-tailed Classification](https://mlsanity.com/paper/2111.04901/) (2021)
- [ConvFormer: Plug-and-Play CNN-Style Transformers for Improving Medical Image Segmentation](https://mlsanity.com/paper/2309.05674/) (2023)
- [XBound-Former: Toward Cross-scale Boundary Modeling in Transformers](https://mlsanity.com/paper/2206.00806/) (2022)
- [Tackling Instance-Dependent Label Noise with Dynamic Distribution Calibration](https://mlsanity.com/paper/2210.05126/) (2022)

## Built on by (most cited first, 1 of 1)

- [DCSNet: Multiscale Feature Aggregation for Small Medical Object Segmentation with Detection-guided Hierarchical Cropping](https://mlsanity.com/paper/2606.28402/) (2026)

## Abstract (arXiv)

Deep learning has achieved significant advancements in medical image segmentation, but existing models still face challenges in accurately segmenting lesion regions. The main reason is that some lesion regions in medical images have unclear boundaries, irregular shapes, and small tissue density differences, leading to label ambiguity. However, the existing model treats all data equally without taking quality differences into account in the training process, resulting in noisy labels negatively impacting model training and unstable feature representations. In this paper, a data-driven alternating learning (DALE) paradigm is proposed to optimize the model's training process, achieving stable and high-precision segmentation. The paradigm focuses on two key points: (1) reducing the impact of noisy labels, and (2) calibrating unstable representations. To mitigate the negative impact of noisy labels, a loss consistency-based collaborative optimization method is proposed, and its effectiveness is theoretically demonstrated. Specifically, the label confidence parameters are introduced to dynamically adjust the influence of labels of different confidence levels during model training, thus reducing the influence of noise labels. To calibrate the learning bias of unstable representations, a distribution alignment method is proposed. This method restores the underlying distribution of unstable representations, thereby enhancing the discriminative capability of fuzzy region representations. Extensive experiments on various benchmarks and model backbones demonstrate the superiority of the DALE paradigm, achieving an average performance improvement of up to 7.16%.