# dFLMoE: Decentralized Federated Learning via Mixture of Experts for Medical Data Analysis

arXiv: https://arxiv.org/abs/2503.10412 · HTML: https://mlsanity.com/paper/2503.10412/

## Key facts

- Cited by 9 papers in the map (data through 14 Oct 2026).
- Placed in Federated mixture-of-experts, one of 12 directions in Mixture-of-experts.
- Builds on 58 of its 81 references that are in the map.
- First posted on arXiv 13 Mar 2025.

## Placed in

- Mixture-of-experts / [Federated mixture-of-experts](https://mlsanity.com/moe/federated-mixture-of-experts/)

## Builds on (most cited first, 30 of 58)

- [U-Net: Convolutional Networks for Biomedical Image Segmentation](https://mlsanity.com/paper/1505.04597/) (2015)
- [Very Deep Convolutional Networks for Large-Scale Image Recognition](https://mlsanity.com/paper/1409.1556/) (2014)
- [Communication-Efficient Learning of Deep Networks from Decentralized Data](https://mlsanity.com/paper/1602.05629/) (2016)
- [Densely Connected Convolutional Networks](https://mlsanity.com/paper/1608.06993/) (2016)
- [Fully Convolutional Networks for Semantic Segmentation](https://mlsanity.com/paper/1411.4038/) (2014)
- [MobileNetV2: Inverted Residuals and Linear Bottlenecks](https://mlsanity.com/paper/1801.04381/) (2018)
- [Squeeze-and-Excitation Networks](https://mlsanity.com/paper/1709.01507/) (2017)
- [Federated Optimization in Heterogeneous Networks](https://mlsanity.com/paper/1812.06127/) (2018)
- [Aggregated Residual Transformations for Deep Neural Networks](https://mlsanity.com/paper/1611.05431/) (2016)
- [Photo-Realistic Single Image Super-Resolution Using a Generative Adversarial Network](https://mlsanity.com/paper/1609.04802/) (2016)
- [An Empirical Evaluation of Generic Convolutional and Recurrent Networks for Sequence Modeling](https://mlsanity.com/paper/1803.01271/) (2018)
- [ShuffleNet V2: Practical Guidelines for Efficient CNN Architecture Design](https://mlsanity.com/paper/1807.11164/) (2018)
- [SqueezeNet: AlexNet-level accuracy with 50x fewer parameters and <0.5MB model size](https://mlsanity.com/paper/1602.07360/) (2016)
- [Ensemble Distillation for Robust Model Fusion in Federated Learning](https://mlsanity.com/paper/2006.07242/) (2020)
- [Ditto: Fair and Robust Federated Learning Through Personalization](https://mlsanity.com/paper/2012.04221/) (2020)
- [UNet++: Redesigning Skip Connections to Exploit Multiscale Features in Image Segmentation](https://mlsanity.com/paper/1912.05074/) (2019)
- [Federated Learning with Personalization Layers](https://mlsanity.com/paper/1912.00818/) (2019)
- [Exploiting Shared Representations for Personalized Federated Learning](https://mlsanity.com/paper/2102.07078/) (2021)
- [Clustered Federated Learning: Model-Agnostic Distributed Multi-Task Optimization under Privacy Constraints](https://mlsanity.com/paper/1910.01991/) (2019)
- [FedMD: Heterogenous Federated Learning via Model Distillation](https://mlsanity.com/paper/1910.03581/) (2019)
- [A Transformer-based Framework for Multivariate Time Series Representation Learning](https://mlsanity.com/paper/2010.02803/) (2020)
- [Adaptive Personalized Federated Learning](https://mlsanity.com/paper/2003.13461/) (2020)
- [Think Locally, Act Globally: Federated Learning with Local and Global Representations](https://mlsanity.com/paper/2001.01523/) (2020)
- [Three Approaches for Personalization with Applications to Federated Learning](https://mlsanity.com/paper/2002.10619/) (2020)
- [Personalized Cross-Silo Federated Learning on Non-IID Data](https://mlsanity.com/paper/2007.03797/) (2020)
- [ResUNet-a: a deep learning framework for semantic segmentation of remotely sensed data](https://mlsanity.com/paper/1904.00592/) (2019)
- [Federated Learning of a Mixture of Global and Local Models](https://mlsanity.com/paper/2002.05516/) (2020)
- [FedHealth: A Federated Transfer Learning Framework for Wearable Healthcare](https://mlsanity.com/paper/1907.09173/) (2019)
- [Polyp-PVT: Polyp Segmentation with Pyramid Vision Transformers](https://mlsanity.com/paper/2108.06932/) (2021)
- [Distillation-Based Semi-Supervised Federated Learning for Communication-Efficient Collaborative Training with Non-IID Private Data](https://mlsanity.com/paper/2008.06180/) (2020)

## Built on by (most cited first, 9 of 9)

- [Aggregation Alignment for Federated Learning with Mixture-of-Experts under Data Heterogeneity](https://mlsanity.com/paper/2603.21276/) (2026)
- [The Rise of Sparse Mixture-of-Experts: A Survey from Algorithmic Foundations to Decentralized Architectures and Vertical Domain Applications](https://mlsanity.com/paper/2602.08019/) (2026)
- [Wireless Federated Multi-Task LLM Fine-Tuning via Sparse-and-Orthogonal LoRA](https://mlsanity.com/paper/2602.20492/) (2026)
- [Robust Client-Server Watermarking for Split Federated Learning](https://mlsanity.com/paper/2511.13598/) (2025)
- [AdaBFL: Multi-Layer Defensive Adaptive Aggregation for Bzantine-Robust Federated Learning](https://mlsanity.com/paper/2604.27434/) (2026)
- [Conflict-Aware Federated Fine-Tuning of Large Language Models with Mixture-of-Experts](https://mlsanity.com/paper/2606.15625/) (2026)
- [FoMoE: Breaking the Full-Replica Barrier with a Federation of MoEs](https://mlsanity.com/paper/2606.19025/) (2026)
- [Fisher-Routed Mixture of Experts for Federated Class-Incremental Learning](https://mlsanity.com/paper/2606.28835/) (2026)
- [Regime-Aware Router Learning for Multi-Domain Medical Image Generation with Diffusion Experts](https://mlsanity.com/paper/2610.16082/) (2026)

## Abstract (arXiv)

Federated learning has wide applications in the medical field. It enables knowledge sharing among different healthcare institutes while protecting patients' privacy. However, existing federated learning systems are typically centralized, requiring clients to upload client-specific knowledge to a central server for aggregation. This centralized approach would integrate the knowledge from each client into a centralized server, and the knowledge would be already undermined during the centralized integration before it reaches back to each client. Besides, the centralized approach also creates a dependency on the central server, which may affect training stability if the server malfunctions or connections are unstable. To address these issues, we propose a decentralized federated learning framework named dFLMoE. In our framework, clients directly exchange lightweight head models with each other. After exchanging, each client treats both local and received head models as individual experts, and utilizes a client-specific Mixture of Experts (MoE) approach to make collective decisions. This design not only reduces the knowledge damage with client-specific aggregations but also removes the dependency on the central server to enhance the robustness of the framework. We validate our framework on multiple medical tasks, demonstrating that our method evidently outperforms state-of-the-art approaches under both model homogeneity and heterogeneity settings.