# Identity Preserving Latent Diffusion for Brain Aging Modeling

arXiv: https://arxiv.org/abs/2503.09634 · HTML: https://mlsanity.com/paper/2503.09634/

## Key facts

- Cited by 1 papers in the map (data through 14 Oct 2026).
- Placed in Medical imaging and segmentation, one of 14 directions in Diffusion models.
- Builds on 45 of its 67 references that are in the map.
- First posted on arXiv 11 Mar 2025.

## Placed in

- Diffusion models / [Medical imaging and segmentation](https://mlsanity.com/diffusion/medical-imaging-and-segmentation/)

## Builds on (most cited first, 30 of 45)

- [Denoising Diffusion Probabilistic Models](https://mlsanity.com/paper/2006.11239/) (2020)
- [High-Resolution Image Synthesis with Latent Diffusion Models](https://mlsanity.com/paper/2112.10752/) (2021)
- [A Simple Framework for Contrastive Learning of Visual Representations](https://mlsanity.com/paper/2002.05709/) (2020)
- [The Unreasonable Effectiveness of Deep Features as a Perceptual Metric](https://mlsanity.com/paper/1801.03924/) (2018)
- [Hierarchical Text-Conditional Image Generation with CLIP Latents](https://mlsanity.com/paper/2204.06125/) (2022)
- [Photorealistic Text-to-Image Diffusion Models with Deep Language Understanding](https://mlsanity.com/paper/2205.11487/) (2022)
- [Adding Conditional Control to Text-to-Image Diffusion Models](https://mlsanity.com/paper/2302.05543/) (2023)
- [Image-to-Image Translation with Conditional Adversarial Networks](https://mlsanity.com/paper/1611.07004/) (2016)
- [GLIDE: Towards Photorealistic Image Generation and Editing with Text-Guided Diffusion Models](https://mlsanity.com/paper/2112.10741/) (2021)
- [InstructPix2Pix: Learning to Follow Image Editing Instructions](https://mlsanity.com/paper/2211.09800/) (2022)
- [Stable Video Diffusion: Scaling Latent Video Diffusion Models to Large Datasets](https://mlsanity.com/paper/2311.15127/) (2023)
- [SDEdit: Guided Image Synthesis and Editing with Stochastic Differential Equations](https://mlsanity.com/paper/2108.01073/) (2021)
- [Align your Latents: High-Resolution Video Synthesis with Latent Diffusion Models](https://mlsanity.com/paper/2304.08818/) (2023)
- [AnimateDiff: Animate Your Personalized Text-to-Image Diffusion Models without Specific Tuning](https://mlsanity.com/paper/2307.04725/) (2023)
- [Blended Diffusion for Text-driven Editing of Natural Images](https://mlsanity.com/paper/2111.14818/) (2021)
- [Multimodal Unsupervised Image-to-Image Translation](https://mlsanity.com/paper/1804.04732/) (2018)
- [Vector-quantized Image Modeling with Improved VQGAN](https://mlsanity.com/paper/2110.04627/) (2021)
- [ModelScope Text-to-Video Technical Report](https://mlsanity.com/paper/2308.06571/) (2023)
- [Unsupervised Image-to-Image Translation Networks](https://mlsanity.com/paper/1703.00848/) (2017)
- [Diffusion Autoencoders: Toward a Meaningful and Decodable Representation](https://mlsanity.com/paper/2111.15640/) (2021)
- [Blended Latent Diffusion](https://mlsanity.com/paper/2206.02779/) (2022)
- [Latent Video Diffusion Models for High-Fidelity Long Video Generation](https://mlsanity.com/paper/2211.13221/) (2022)
- [DualGAN: Unsupervised Dual Learning for Image-to-Image Translation](https://mlsanity.com/paper/1704.02510/) (2017)
- [Contrastive learning of global and local features for medical image segmentation with limited annotations](https://mlsanity.com/paper/2006.10511/) (2020)
- [Inversion-Based Style Transfer with Diffusion Models](https://mlsanity.com/paper/2211.13203/) (2022)
- [Brain Imaging Generation with Latent Diffusion Models](https://mlsanity.com/paper/2209.07162/) (2022)
- [Generating Long Videos of Dynamic Scenes](https://mlsanity.com/paper/2206.03429/) (2022)
- [Lifespan Age Transformation Synthesis](https://mlsanity.com/paper/2003.09764/) (2020)
- [SADM: Sequence-Aware Diffusion Model for Longitudinal Medical Image Generation](https://mlsanity.com/paper/2212.08228/) (2022)
- [Reuse and Diffuse: Iterative Denoising for Text-to-Video Generation](https://mlsanity.com/paper/2309.03549/) (2023)

## Built on by (most cited first, 1 of 1)

- [Delta-Diffusion: Modeling Longitudinal Brain Amyloid-PET Trajectories via Conditional Poisson Diffusion Bridge](https://mlsanity.com/paper/2606.22216/) (2026)

## Abstract (arXiv)

Structural and appearance changes in brain imaging over time are crucial indicators of neurodevelopment and neurodegeneration. The rapid advancement of large-scale generative models provides a promising backbone for modeling these complex global and local changes in brain images, such as transforming the age of a source image to a target age. However, current generative models, typically trained on independently and identically distributed (i.i.d.) data, may struggle to maintain intra-subject spatiotemporal consistency during transformations. We propose the Identity-Preserving Longitudinal Diffusion Model (IP-LDM), designed to accurately transform brain ages while preserving subject identity. Our approach involves first extracting the identity representation from the source image. Then, conditioned on the target age, the latent diffusion model learns to generate the age-transformed target image. To ensure consistency within the same subject over time, we regularize the identity representation using a triplet contrastive formulation. Our experiments on both elderly and infant brain datasets demonstrate that our model outperforms existing conditional generative models, producing realistic age transformations while preserving intra-subject identity.