# ExKG-LLM: Leveraging Large Language Models for Automated Expansion of Cognitive Neuroscience Knowledge Graphs

arXiv: https://arxiv.org/abs/2503.06479 · HTML: https://mlsanity.com/paper/2503.06479/

## Key facts

- Cited by 2 papers in the map (data through 14 Oct 2026).
- Builds on 14 of its 32 references that are in the map.
- First posted on arXiv 9 Mar 2025.

## Builds on (most cited first, 14 of 14)

- [Attention Is All You Need](https://mlsanity.com/paper/1706.03762/) (2017)
- [A Survey of Large Language Models](https://mlsanity.com/paper/2303.18223/) (2023)
- [BioBERT: a pre-trained biomedical language representation model for biomedical text mining](https://mlsanity.com/paper/1901.08746/) (2019)
- [Large Language Models Encode Clinical Knowledge](https://mlsanity.com/paper/2212.13138/) (2022)
- [Embedding Entities and Relations for Learning and Inference in Knowledge Bases](https://mlsanity.com/paper/1412.6575/) (2014)
- [Complex Embeddings for Simple Link Prediction](https://mlsanity.com/paper/1606.06357/) (2016)
- [RotatE: Knowledge Graph Embedding by Relational Rotation in Complex Space](https://mlsanity.com/paper/1902.10197/) (2019)
- [Convolutional 2D Knowledge Graph Embeddings](https://mlsanity.com/paper/1707.01476/) (2017)
- [Building a PubMed knowledge graph](https://mlsanity.com/paper/2005.04308/) (2020)
- [Knowledge Graph-Enhanced Large Language Models via Path Selection](https://mlsanity.com/paper/2406.13862/) (2024)
- [Trans4E: Link Prediction on Scholarly Knowledge Graphs](https://mlsanity.com/paper/2107.03297/) (2021)
- [Relation Extraction from Biomedical and Clinical Text: Unified Multitask Learning Framework](https://mlsanity.com/paper/2009.09509/) (2020)
- [Clinical Named Entity Recognition using Contextualized Token Representations](https://mlsanity.com/paper/2106.12608/) (2021)
- [Coronavirus Knowledge Graph: A Case Study](https://mlsanity.com/paper/2007.10287/) (2020)

## Built on by (most cited first, 2 of 2)

- [SpineBench: A Clinically Salient, Level-Aware Benchmark Powered by the SpineMed-450k Corpus](https://mlsanity.com/paper/2510.03160/) (2025)
- [Enhancing Serendipity Recommendation System by Constructing Dynamic User Knowledge Graphs with Large Language Models](https://mlsanity.com/paper/2508.04032/) (2025)

## Abstract (arXiv)

The paper introduces ExKG-LLM, a framework designed to automate the expansion of cognitive neuroscience knowledge graphs (CNKG) using large language models (LLMs). It addresses limitations in existing tools by enhancing accuracy, completeness, and usefulness in CNKG. The framework leverages a large dataset of scientific papers and clinical reports, applying state-of-the-art LLMs to extract, optimize, and integrate new entities and relationships. Evaluation metrics include precision, recall, and graph density. Results show significant improvements: precision (0.80, +6.67%), recall (0.81, +15.71%), F1 score (0.805, +11.81%), and increased edge nodes (21.13% and 31.92%). Graph density slightly decreased, reflecting a broader but more fragmented structure. Engagement rates rose by 20%, while CNKG diameter increased to 15, indicating a more distributed structure. Time complexity improved to O(n log n), but space complexity rose to O(n2), indicating higher memory usage. ExKG-LLM demonstrates potential for enhancing knowledge generation, semantic search, and clinical decision-making in cognitive neuroscience, adaptable to broader scientific fields.