# Correctness Coverage Evaluation for Medical Multiple-Choice Question Answering Based on the Enhanced Conformal Prediction Framework

arXiv: https://arxiv.org/abs/2503.05505 · HTML: https://mlsanity.com/paper/2503.05505/

## Key facts

- Cited by 1 papers in the map (data through 14 Oct 2026).
- Builds on 11 of its 16 references that are in the map.
- First posted on arXiv 7 Mar 2025.

## Builds on (most cited first, 11 of 11)

- [Language Models are Few-Shot Learners](https://mlsanity.com/paper/2005.14165/) (2020)
- [Training language models to follow instructions with human feedback](https://mlsanity.com/paper/2203.02155/) (2022)
- [A Survey on Hallucination in Large Language Models: Principles, Taxonomy, Challenges, and Open Questions](https://mlsanity.com/paper/2311.05232/) (2023)
- [A Survey of Large Language Models for Healthcare: from Data, Technology, and Applications to Accountability and Ethics](https://mlsanity.com/paper/2310.05694/) (2023)
- [Shifting Attention to Relevance: Towards the Predictive Uncertainty Quantification of Free-Form Large Language Models](https://mlsanity.com/paper/2307.01379/) (2023)
- [Benchmarking LLMs via Uncertainty Quantification](https://mlsanity.com/paper/2401.12794/) (2024)
- [Quantifying Uncertainty in Answers from any Language Model and Enhancing their Trustworthiness](https://mlsanity.com/paper/2308.16175/) (2023)
- [Selection by Prediction with Conformal p-values](https://mlsanity.com/paper/2210.01408/) (2022)
- [ConU: Conformal Uncertainty in Large Language Models with Correctness Coverage Guarantees](https://mlsanity.com/paper/2407.00499/) (2024)
- [Conformal Prediction for Natural Language Processing: A Survey](https://mlsanity.com/paper/2405.01976/) (2024)
- [Word-Sequence Entropy: Towards Uncertainty Estimation in Free-Form Medical Question Answering Applications and Beyond](https://mlsanity.com/paper/2402.14259/) (2024)

## Built on by (most cited first, 1 of 1)

- [What Does Neuro Mean to Cardio? Investigating the Role of Clinical Specialty Data in Medical LLMs](https://mlsanity.com/paper/2505.10113/) (2025)

## Abstract (arXiv)

Large language models (LLMs) are increasingly adopted in medical question-answering (QA) scenarios. However, LLMs can generate hallucinations and nonfactual information, undermining their trustworthiness in high-stakes medical tasks. Conformal Prediction (CP) provides a statistically rigorous framework for marginal (average) coverage guarantees but has limited exploration in medical QA. This paper proposes an enhanced CP framework for medical multiple-choice question-answering (MCQA) tasks. By associating the non-conformance score with the frequency score of correct options and leveraging self-consistency, the framework addresses internal model opacity and incorporates a risk control strategy with a monotonic loss function. Evaluated on MedMCQA, MedQA, and MMLU datasets using four off-the-shelf LLMs, the proposed method meets specified error rate guarantees while reducing average prediction set size with increased risk level, offering a promising uncertainty evaluation metric for LLMs.