# RiskAgent: Synergizing Language Models with Validated Tools for Evidence-Based Risk Prediction

arXiv: https://arxiv.org/abs/2503.03802 · HTML: https://mlsanity.com/paper/2503.03802/

## Key facts

- Cited by 3 papers in the map (data through 14 Oct 2026).
- Builds on 28 of its 48 references that are in the map.
- First posted on arXiv 5 Mar 2025.

## Builds on (most cited first, 28 of 28)

- [GPT-4 Technical Report](https://mlsanity.com/paper/2303.08774/) (2023)
- [LoRA: Low-Rank Adaptation of Large Language Models](https://mlsanity.com/paper/2106.09685/) (2021)
- [LLaMA: Open and Efficient Foundation Language Models](https://mlsanity.com/paper/2302.13971/) (2023)
- [Llama 2: Open Foundation and Fine-Tuned Chat Models](https://mlsanity.com/paper/2307.09288/) (2023)
- [ReAct: Synergizing Reasoning and Acting in Language Models](https://mlsanity.com/paper/2210.03629/) (2022)
- [Measuring Massive Multitask Language Understanding](https://mlsanity.com/paper/2009.03300/) (2020)
- [PaLM: Scaling Language Modeling with Pathways](https://mlsanity.com/paper/2204.02311/) (2022)
- [GPT-4o System Card](https://mlsanity.com/paper/2410.21276/) (2024)
- [Mistral 7B](https://mlsanity.com/paper/2310.06825/) (2023)
- [A Survey on Large Language Model based Autonomous Agents](https://mlsanity.com/paper/2308.11432/) (2023)
- [Survey of Hallucination in Natural Language Generation](https://mlsanity.com/paper/2202.03629/) (2022)
- [Mixtral of Experts](https://mlsanity.com/paper/2401.04088/) (2024)
- [LlamaFactory: Unified Efficient Fine-Tuning of 100+ Language Models](https://mlsanity.com/paper/2403.13372/) (2024)
- [What Disease does this Patient Have? A Large-scale Open Domain Question Answering Dataset from Medical Exams](https://mlsanity.com/paper/2009.13081/) (2020)
- [MedMCQA : A Large-scale Multi-Subject Multi-Choice Dataset for Medical domain Question Answering](https://mlsanity.com/paper/2203.14371/) (2022)
- [Towards Expert-Level Medical Question Answering with Large Language Models](https://mlsanity.com/paper/2305.09617/) (2023)
- [Chameleon: Plug-and-Play Compositional Reasoning with Large Language Models](https://mlsanity.com/paper/2304.09842/) (2023)
- [Can Generalist Foundation Models Outcompete Special-Purpose Tuning? Case Study in Medicine](https://mlsanity.com/paper/2311.16452/) (2023)
- [MedAgents: Large Language Models as Collaborators for Zero-shot Medical Reasoning](https://mlsanity.com/paper/2311.10537/) (2023)
- [MEDITRON-70B: Scaling Medical Pretraining for Large Language Models](https://mlsanity.com/paper/2311.16079/) (2023)
- [Adapted Large Language Models Can Outperform Medical Experts in Clinical Text Summarization](https://mlsanity.com/paper/2309.07430/) (2023)
- [Med-HALT: Medical Domain Hallucination Test for Large Language Models](https://mlsanity.com/paper/2307.15343/) (2023)
- [A Survey of Large Language Models in Medicine: Progress, Application, and Challenge](https://mlsanity.com/paper/2311.05112/) (2023)
- [Advancing Multimodal Medical Capabilities of Gemini](https://mlsanity.com/paper/2405.03162/) (2024)
- [BOLAA: Benchmarking and Orchestrating LLM-augmented Autonomous Agents](https://mlsanity.com/paper/2308.05960/) (2023)
- [AutoAct: Automatic Agent Learning from Scratch for QA via Self-Planning](https://mlsanity.com/paper/2401.05268/) (2024)
- [MedCalc-Bench: Evaluating Large Language Models for Medical Calculations](https://mlsanity.com/paper/2406.12036/) (2024)
- [AgentMD: Empowering Language Agents for Risk Prediction with Large-Scale Clinical Tool Learning](https://mlsanity.com/paper/2402.13225/) (2024)

## Built on by (most cited first, 3 of 3)

- [MedCalc-Bench Doesn't Measure What You Think: A Benchmark Audit and the Case for Open-Book Evaluation](https://mlsanity.com/paper/2603.02222/) (2026)
- [Beyond the Leaderboard: Rethinking Medical Benchmarks for Large Language Models](https://mlsanity.com/paper/2508.04325/) (2025)
- [Agentic systems for breast cancer treatment recommendations](https://mlsanity.com/paper/2607.12051/) (2026)

## Abstract (arXiv)

Large Language Models (LLMs) achieve competitive results compared to human experts in medical examinations. However, it remains a challenge to apply LLMs to complex clinical decision-making, which requires a deep understanding of medical knowledge and differs from the standardized, exam-style scenarios commonly used in current efforts. A common approach is to fine-tune LLMs for target tasks, which, however, not only requires substantial data and computational resources but also remains prone to generating `hallucinations'. In this work, we present RiskAgent, which synergizes language models with hundreds of validated clinical decision tools supported by evidence-based medicine, to provide generalizable and faithful recommendations. Our experiments show that RiskAgent not only achieves superior performance on a broad range of clinical risk predictions across diverse scenarios and diseases, but also demonstrates robust generalization in tool learning on the external MedCalc-Bench dataset, as well as in medical reasoning and question answering on three representative benchmarks, MedQA, MedMCQA, and MMLU.