# Distilled Prompt Learning for Incomplete Multimodal Survival Prediction

arXiv: https://arxiv.org/abs/2503.01653 · HTML: https://mlsanity.com/paper/2503.01653/

## Key facts

- Cited by 11 papers in the map (data through 14 Oct 2026).
- Builds on 26 of its 45 references that are in the map.
- First posted on arXiv 3 Mar 2025.

## Builds on (most cited first, 26 of 26)

- [Learning to Prompt for Vision-Language Models](https://mlsanity.com/paper/2109.01134/) (2021)
- [BioBERT: a pre-trained biomedical language representation model for biomedical text mining](https://mlsanity.com/paper/1901.08746/) (2019)
- [LLaVA-Med: Training a Large Language-and-Vision Assistant for Biomedicine in One Day](https://mlsanity.com/paper/2306.00890/) (2023)
- [Attention-based Deep Multiple Instance Learning](https://mlsanity.com/paper/1802.04712/) (2018)
- [Diffusion Models in Vision: A Survey](https://mlsanity.com/paper/2209.04747/) (2022)
- [Self-Normalizing Neural Networks](https://mlsanity.com/paper/1706.02515/) (2017)
- [TransMIL: Transformer based Correlated Multiple Instance Learning for Whole Slide Image Classification](https://mlsanity.com/paper/2106.00908/) (2021)
- [Dual-stream Multiple Instance Learning Network for Whole Slide Image Classification with Self-supervised Contrastive Learning](https://mlsanity.com/paper/2011.08939/) (2020)
- [DTFD-MIL: Double-Tier Feature Distillation Multiple Instance Learning for Histopathology Whole Slide Image Classification](https://mlsanity.com/paper/2203.12081/) (2022)
- [SMIL: Multimodal Learning with Severely Missing Modality](https://mlsanity.com/paper/2103.05677/) (2021)
- [Multi-modal Learning with Missing Modality via Shared-Specific Feature Modelling](https://mlsanity.com/paper/2307.14126/) (2023)
- [Multimodal Prompting with Missing Modalities for Visual Recognition](https://mlsanity.com/paper/2303.03369/) (2023)
- [Missing MRI Pulse Sequence Synthesis using Multi-Modal Generative Adversarial Network](https://mlsanity.com/paper/1904.12200/) (2019)
- [Modeling Dense Multimodal Interactions Between Biological Pathways and Histology for Survival Prediction](https://mlsanity.com/paper/2304.06819/) (2023)
- [MambaMIL: Enhancing Long Sequence Modeling with Sequence Reordering in Computational Pathology](https://mlsanity.com/paper/2403.06800/) (2024)
- [Multimodal Optimal Transport-based Co-Attention Transformer with Global Structure Consistency for Survival Prediction](https://mlsanity.com/paper/2306.08330/) (2023)
- [M3Care: Learning with Missing Modalities in Multimodal Healthcare Data](https://mlsanity.com/paper/2210.17292/) (2022)
- [Cross-Modal Translation and Alignment for Survival Analysis](https://mlsanity.com/paper/2309.12855/) (2023)
- [Multiple Instance Learning for Digital Pathology: A Review on the State-of-the-Art, Limitations & Future Potential](https://mlsanity.com/paper/2206.04425/) (2022)
- [Multimodal Prototyping for cancer survival prediction](https://mlsanity.com/paper/2407.00224/) (2024)
- [Prototypical Information Bottlenecking and Disentangling for Multimodal Cancer Survival Prediction](https://mlsanity.com/paper/2401.01646/) (2024)
- [MoME: Mixture of Multimodal Experts for Cancer Survival Prediction](https://mlsanity.com/paper/2406.09696/) (2024)
- [ModDrop++: A Dynamic Filter Network with Intra-subject Co-training for Multiple Sclerosis Lesion Segmentation with Missing Modalities](https://mlsanity.com/paper/2203.04959/) (2022)
- [Modality Completion via Gaussian Process Prior Variational Autoencoders for Multi-Modal Glioma Segmentation](https://mlsanity.com/paper/2107.03442/) (2021)
- [Multimodal Data Integration for Precision Oncology: Challenges and Future Directions](https://mlsanity.com/paper/2406.19611/) (2024)
- [GTP-4o: Modality-prompted Heterogeneous Graph Learning for Omni-modal Biomedical Representation](https://mlsanity.com/paper/2407.05540/) (2024)

## Built on by (most cited first, 11 of 11)

- [Inference-Time Dynamic Modality Selection for Incomplete Multimodal Classification](https://mlsanity.com/paper/2601.22853/) (2026)
- [Cross-Cancer Knowledge Transfer in WSI-based Prognosis Prediction](https://mlsanity.com/paper/2508.13482/) (2025)
- [A Flow Model with Low-Rank Transformers for Incomplete Multimodal Survival Analysis](https://mlsanity.com/paper/2510.21829/) (2025)
- [Together, Then Apart: Balancing Alignment and Distinctiveness for Multimodal Survival Analysis](https://mlsanity.com/paper/2511.18089/) (2025)
- [Spatio-Temporal Conditional Denoising Transformer for Modality-Missing RGBT Tracking](https://mlsanity.com/paper/2607.24701/) (2026)
- [Investigating Trustworthiness of Nonparametric Deep Survival Models for Alzheimer's Disease Progression Analysis](https://mlsanity.com/paper/2605.04063/) (2026)
- [Robust Fuzzy Multi-view Learning under View Conflict](https://mlsanity.com/paper/2605.24475/) (2026)
- [Multi-FRuGaL: Multimodal Flexible Redundancy-aware Decomposed Gated Learning for Cancer Diagnosis and Prognosis](https://mlsanity.com/paper/2606.06867/) (2026)
- [Evidential Fusion Network for Multimodal Survival Prediction under Missing Modalities](https://mlsanity.com/paper/2606.20757/) (2026)
- [Learning to Act under Visual Interruptions with Vision-Language-Action Models](https://mlsanity.com/paper/2609.35003/) (2026)
- [Do More Modalities Always Help? A Geometric Perspective on Missing-Modality Robustness](https://mlsanity.com/paper/2610.04792/) (2026)

## Abstract (arXiv)

The integration of multimodal data including pathology images and gene profiles is widely applied in precise survival prediction. Despite recent advances in multimodal survival models, collecting complete modalities for multimodal fusion still poses a significant challenge, hindering their application in clinical settings. Current approaches tackling incomplete modalities often fall short, as they typically compensate for only a limited part of the knowledge of missing modalities. To address this issue, we propose a Distilled Prompt Learning framework (DisPro) to utilize the strong robustness of Large Language Models (LLMs) to missing modalities, which employs two-stage prompting for compensation of comprehensive information for missing modalities. In the first stage, Unimodal Prompting (UniPro) distills the knowledge distribution of each modality, preparing for supplementing modality-specific knowledge of the missing modality in the subsequent stage. In the second stage, Multimodal Prompting (MultiPro) leverages available modalities as prompts for LLMs to infer the missing modality, which provides modality-common information. Simultaneously, the unimodal knowledge acquired in the first stage is injected into multimodal inference to compensate for the modality-specific knowledge of the missing modality. Extensive experiments covering various missing scenarios demonstrated the superiority of the proposed method. The code is available at https://github.com/Innse/DisPro.