# PathVG: A New Benchmark and Dataset for Pathology Visual Grounding

arXiv: https://arxiv.org/abs/2502.20869 · HTML: https://mlsanity.com/paper/2502.20869/

## Key facts

- Cited by 2 papers in the map (data through 14 Oct 2026).
- Builds on 16 of its 20 references that are in the map.
- First posted on arXiv 28 Feb 2025.

## Builds on (most cited first, 16 of 16)

- [LLaVA-Med: Training a Large Language-and-Vision Assistant for Biomedicine in One Day](https://mlsanity.com/paper/2306.00890/) (2023)
- [Attention-based Deep Multiple Instance Learning](https://mlsanity.com/paper/1802.04712/) (2018)
- [Data Efficient and Weakly Supervised Computational Pathology on Whole Slide Images](https://mlsanity.com/paper/2004.09666/) (2020)
- [TransMIL: Transformer based Correlated Multiple Instance Learning for Whole Slide Image Classification](https://mlsanity.com/paper/2106.00908/) (2021)
- [YOLOv10: Real-Time End-to-End Object Detection](https://mlsanity.com/paper/2405.14458/) (2024)
- [PathVQA: 30000+ Questions for Medical Visual Question Answering](https://mlsanity.com/paper/2003.10286/) (2020)
- [Making the Most of Text Semantics to Improve Biomedical Vision--Language Processing](https://mlsanity.com/paper/2204.09817/) (2022)
- [TransVG: End-to-End Visual Grounding with Transformers](https://mlsanity.com/paper/2104.08541/) (2021)
- [SeqTR: A Simple yet Universal Network for Visual Grounding](https://mlsanity.com/paper/2203.16265/) (2022)
- [PathMMU: A Massive Multimodal Expert-Level Benchmark for Understanding and Reasoning in Pathology](https://mlsanity.com/paper/2401.16355/) (2024)
- [SimVG: A Simple Framework for Visual Grounding with Decoupled Multi-modal Fusion](https://mlsanity.com/paper/2409.17531/) (2024)
- [CLIP-VG: Self-paced Curriculum Adapting of CLIP for Visual Grounding](https://mlsanity.com/paper/2305.08685/) (2023)
- [Medical Phrase Grounding with Region-Phrase Context Contrastive Alignment](https://mlsanity.com/paper/2303.07618/) (2023)
- [Dynamic MDETR: A Dynamic Multimodal Transformer Decoder for Visual Grounding](https://mlsanity.com/paper/2209.13959/) (2022)
- [Context Disentangling and Prototype Inheriting for Robust Visual Grounding](https://mlsanity.com/paper/2312.11967/) (2023)
- [A Refer-and-Ground Multimodal Large Language Model for Biomedicine](https://mlsanity.com/paper/2406.18146/) (2024)

## Built on by (most cited first, 2 of 2)

- [Pix2Fact: When Vision Is Not Enough -- Benchmarking Fine-Grained VQA with Web Verification on High-Resolution Real-World Scenes](https://mlsanity.com/paper/2602.00593/) (2026)
- [Do Pathology Vision-Language Models Truly See Pathology?](https://mlsanity.com/paper/2607.21065/) (2026)

## Abstract (arXiv)

With the rapid development of computational pathology, many AI-assisted diagnostic tasks have emerged. Cellular nuclei segmentation can segment various types of cells for downstream analysis, but it relies on predefined categories and lacks flexibility. Moreover, pathology visual question answering can perform image-level understanding but lacks region-level detection capability. To address this, we propose a new benchmark called Pathology Visual Grounding (PathVG), which aims to detect regions based on expressions with different attributes. To evaluate PathVG, we create a new dataset named RefPath which contains 27,610 images with 33,500 language-grounded boxes. Compared to visual grounding in other domains, PathVG presents pathological images at multi-scale and contains expressions with pathological knowledge. In the experimental study, we found that the biggest challenge was the implicit information underlying the pathological expressions. Based on this, we proposed Pathology Knowledge-enhanced Network (PKNet) as the baseline model for PathVG. PKNet leverages the knowledge-enhancement capabilities of Large Language Models (LLMs) to convert pathological terms with implicit information into explicit visual features, and fuses knowledge features with expression features through the designed Knowledge Fusion Module (KFM). The proposed method achieves state-of-the-art performance on the PathVG benchmark.