# Robust sensitivity control in digital pathology via tile score distribution matching

arXiv: https://arxiv.org/abs/2502.20144 · HTML: https://mlsanity.com/paper/2502.20144/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 9 of its 25 references that are in the map.
- First posted on arXiv 27 Feb 2025.

## Builds on (most cited first, 9 of 9)

- [On Calibration of Modern Neural Networks](https://mlsanity.com/paper/1706.04599/) (2017)
- [In Search of Lost Domain Generalization](https://mlsanity.com/paper/2007.01434/) (2020)
- [Quantifying the effects of data augmentation and stain color normalization in convolutional neural networks for computational pathology](https://mlsanity.com/paper/1902.06543/) (2019)
- [Phikon-v2, A large and public feature extractor for biomarker prediction](https://mlsanity.com/paper/2409.09173/) (2024)
- [Multiple Instance Learning for Digital Pathology: A Review on the State-of-the-Art, Limitations & Future Potential](https://mlsanity.com/paper/2206.04425/) (2022)
- [Text-guided Foundation Model Adaptation for Pathological Image Classification](https://mlsanity.com/paper/2307.14901/) (2023)
- [Predicting Axillary Lymph Node Metastasis in Early Breast Cancer Using Deep Learning on Primary Tumor Biopsy Slides](https://mlsanity.com/paper/2112.02222/) (2021)
- [Classification and Disease Localization in Histopathology Using Only Global Labels: A Weakly-Supervised Approach](https://mlsanity.com/paper/1802.02212/) (2018)
- [HEROHE Challenge: assessing HER2 status in breast cancer without immunohistochemistry or in situ hybridization](https://mlsanity.com/paper/2111.04738/) (2021)

## Abstract (arXiv)

Deploying digital pathology models across medical centers is challenging due to distribution shifts. Recent advances in domain generalization improve model transferability in terms of aggregated performance measured by the Area Under Curve (AUC). However, clinical regulations often require to control the transferability of other metrics, such as prescribed sensitivity levels. We introduce a novel approach to control the sensitivity of whole slide image (WSI) classification models, based on optimal transport and Multiple Instance Learning (MIL). Validated across multiple cohorts and tasks, our method enables robust sensitivity control with only a handful of calibration samples, providing a practical solution for reliable deployment of computational pathology systems.