# Efficient 4D fMRI ASD Classification using Spatial-Temporal-Omics-based Learning Framework

arXiv: https://arxiv.org/abs/2502.19386 · HTML: https://mlsanity.com/paper/2502.19386/

## Key facts

- Cited by 1 papers in the map (data through 14 Oct 2026).
- Builds on 6 of its 23 references that are in the map.
- First posted on arXiv 26 Feb 2025.

## Builds on (most cited first, 6 of 6)

- [Multi-site fMRI Analysis Using Privacy-preserving Federated Learning and Domain Adaptation: ABIDE Results](https://mlsanity.com/paper/2001.05647/) (2020)
- [ASD-DiagNet: A hybrid learning approach for detection of Autism Spectrum Disorder using fMRI data](https://mlsanity.com/paper/1904.07577/) (2019)
- [Pooling Regularized Graph Neural Network for fMRI Biomarker Analysis](https://mlsanity.com/paper/2007.14589/) (2020)
- [Simple 1-D Convolutional Networks for Resting-State fMRI Based Classification in Autism](https://mlsanity.com/paper/1907.01288/) (2019)
- [A Hybrid 3DCNN and 3DC-LSTM based model for 4D Spatio-temporal fMRI data: An ABIDE Autism Classification study](https://mlsanity.com/paper/2002.05981/) (2020)
- [4D Spatio-Temporal Deep Learning with 4D fMRI Data for Autism Spectrum Disorder Classification](https://mlsanity.com/paper/2004.10165/) (2020)

## Built on by (most cited first, 1 of 1)

- [FedSKD: Aggregation-free Model-heterogeneous Federated Learning via Multi-dimensional Similarity Knowledge Distillation for Medical Image Classification](https://mlsanity.com/paper/2503.18981/) (2025)

## Abstract (arXiv)

Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder impacting social and behavioral development. Resting-state fMRI, a non-invasive tool for capturing brain connectivity patterns, aids in early ASD diagnosis and differentiation from typical controls (TC). However, previous methods, which rely on either mean time series or full 4D data, are limited by a lack of spatial information or by high computational costs. This underscores the need for an efficient solution that preserves both spatial and temporal information. In this paper, we propose a novel, simple, and efficient spatial-temporal-omics learning framework designed to efficiently extract spatio-temporal features from fMRI for ASD classification. Our approach addresses these limitations by utilizing 3D time-domain derivatives as the spatial-temporal inter-voxel omics, which preserve full spatial resolution while capturing diverse statistical characteristics of the time series at each voxel. Meanwhile, functional connectivity features serve as the spatial-temporal inter-regional omics, capturing correlations across brain regions. Extensive experiments and ablation studies on the ABIDE dataset demonstrate that our framework significantly outperforms previous methods while maintaining computational efficiency. We believe our research offers valuable insights that will inform and advance future ASD studies, particularly in the realm of spatial-temporal-omics-based learning.