# Compressing Language Models for Specialized Domains

arXiv: https://arxiv.org/abs/2502.18424 · HTML: https://mlsanity.com/paper/2502.18424/

## Key facts

- Cited by 4 papers in the map (data through 14 Oct 2026).
- Builds on 61 of its 90 references that are in the map.
- First posted on arXiv 25 Feb 2025.

## Builds on (most cited first, 30 of 61)

- [Attention Is All You Need](https://mlsanity.com/paper/1706.03762/) (2017)
- [BERT: Pre-training of Deep Bidirectional Transformers for Language Understanding](https://mlsanity.com/paper/1810.04805/) (2018)
- [Language Models are Few-Shot Learners](https://mlsanity.com/paper/2005.14165/) (2020)
- [Exploring the Limits of Transfer Learning with a Unified Text-to-Text Transformer](https://mlsanity.com/paper/1910.10683/) (2019)
- [Llama 2: Open Foundation and Fine-Tuned Chat Models](https://mlsanity.com/paper/2307.09288/) (2023)
- [Measuring Massive Multitask Language Understanding](https://mlsanity.com/paper/2009.03300/) (2020)
- [mixup: Beyond Empirical Risk Minimization](https://mlsanity.com/paper/1710.09412/) (2017)
- [Think you have Solved Question Answering? Try ARC, the AI2 Reasoning Challenge](https://mlsanity.com/paper/1803.05457/) (2018)
- [HellaSwag: Can a Machine Really Finish Your Sentence?](https://mlsanity.com/paper/1905.07830/) (2019)
- [Pointer Sentinel Mixture Models](https://mlsanity.com/paper/1609.07843/) (2016)
- [PIQA: Reasoning about Physical Commonsense in Natural Language](https://mlsanity.com/paper/1911.11641/) (2019)
- [BoolQ: Exploring the Surprising Difficulty of Natural Yes/No Questions](https://mlsanity.com/paper/1905.10044/) (2019)
- [Learning both Weights and Connections for Efficient Neural Networks](https://mlsanity.com/paper/1506.02626/) (2015)
- [Gemma 2: Improving Open Language Models at a Practical Size](https://mlsanity.com/paper/2408.00118/) (2024)
- [BioBERT: a pre-trained biomedical language representation model for biomedical text mining](https://mlsanity.com/paper/1901.08746/) (2019)
- [Large Language Models Encode Clinical Knowledge](https://mlsanity.com/paper/2212.13138/) (2022)
- [mT5: A massively multilingual pre-trained text-to-text transformer](https://mlsanity.com/paper/2010.11934/) (2020)
- [What Disease does this Patient Have? A Large-scale Open Domain Question Answering Dataset from Medical Exams](https://mlsanity.com/paper/2009.13081/) (2020)
- [AWQ: Activation-aware Weight Quantization for LLM Compression and Acceleration](https://mlsanity.com/paper/2306.00978/) (2023)
- [PubMedQA: A Dataset for Biomedical Research Question Answering](https://mlsanity.com/paper/1909.06146/) (2019)
- [SparseGPT: Massive Language Models Can Be Accurately Pruned in One-Shot](https://mlsanity.com/paper/2301.00774/) (2023)
- [Domain-Specific Language Model Pretraining for Biomedical Natural Language Processing](https://mlsanity.com/paper/2007.15779/) (2020)
- [The LAMBADA dataset: Word prediction requiring a broad discourse context](https://mlsanity.com/paper/1606.06031/) (2016)
- [A Survey of Quantization Methods for Efficient Neural Network Inference](https://mlsanity.com/paper/2103.13630/) (2021)
- [Up or Down? Adaptive Rounding for Post-Training Quantization](https://mlsanity.com/paper/2004.10568/) (2020)
- [OLMo: Accelerating the Science of Language Models](https://mlsanity.com/paper/2402.00838/) (2024)
- [BioGPT: Generative Pre-trained Transformer for Biomedical Text Generation and Mining](https://mlsanity.com/paper/2210.10341/) (2022)
- [A Corpus and Evaluation Framework for Deeper Understanding of Commonsense Stories](https://mlsanity.com/paper/1604.01696/) (2016)
- [Movement Pruning: Adaptive Sparsity by Fine-Tuning](https://mlsanity.com/paper/2005.07683/) (2020)
- [SpQR: A Sparse-Quantized Representation for Near-Lossless LLM Weight Compression](https://mlsanity.com/paper/2306.03078/) (2023)

## Built on by (most cited first, 4 of 4)

- [Leave it to the Specialist: Repair Sparse LLMs with Sparse Fine-Tuning via Sparsity Evolution](https://mlsanity.com/paper/2505.24037/) (2025)
- [GAPrune: Gradient-Alignment Pruning for Domain-Aware Embeddings](https://mlsanity.com/paper/2509.10844/) (2025)
- [On the Utility and Factual Reliability of Pruned Mixture-of-Experts Models in the Biomedical Domain](https://mlsanity.com/paper/2607.01444/) (2026)
- [Damage Predicts Recovery: When Calibration Data Matters in Compressing Financial LLMs](https://mlsanity.com/paper/2609.26241/) (2026)

## Abstract (arXiv)

Language models (LMs) excel at tasks across diverse domains, yet require substantial computational resources during inference. Compression techniques such as pruning and quantization offer a practical path towards efficient LM deployment, exemplified by their ability to preserve performance on general-purpose benchmarks. However, general-purpose LM compression methods can negatively affect performance in specialized domains (e.g. biomedical or legal). Recent work has sought to address this issue, but requires a computationally expensive full-parameter fine-tuning pipeline. To this end, we propose MixCal, a novel calibration method designed to improve the in-domain performance of compressed LMs in a post-training setting. Through extensive experimentation, we demonstrate that MixCal substantially outperforms existing approaches on domain-specific tasks and preserves general performance. Notably, these performance gains are achieved while also reducing the computational cost of LM compression.