# TabulaTime: A Novel Multimodal Deep Learning Framework for Advancing Acute Coronary Syndrome Prediction through Environmental and Clinical Data Integration

arXiv: https://arxiv.org/abs/2502.17049 · HTML: https://mlsanity.com/paper/2502.17049/

## Key facts

- Cited by 1 papers in the map (data through 14 Oct 2026).
- Builds on 13 of its 71 references that are in the map.
- First posted on arXiv 24 Feb 2025.

## Builds on (most cited first, 13 of 13)

- [Neural Machine Translation by Jointly Learning to Align and Translate](https://mlsanity.com/paper/1409.0473/) (2014)
- [Learning Phrase Representations using RNN Encoder-Decoder for Statistical Machine Translation](https://mlsanity.com/paper/1406.1078/) (2014)
- [A Time Series is Worth 64 Words: Long-term Forecasting with Transformers](https://mlsanity.com/paper/2211.14730/) (2022)
- [Autoformer: Decomposition Transformers with Auto-Correlation for Long-Term Series Forecasting](https://mlsanity.com/paper/2106.13008/) (2021)
- [Are Transformers Effective for Time Series Forecasting?](https://mlsanity.com/paper/2205.13504/) (2022)
- [TimesNet: Temporal 2D-Variation Modeling for General Time Series Analysis](https://mlsanity.com/paper/2210.02186/) (2022)
- [All Models are Wrong, but Many are Useful: Learning a Variable's Importance by Studying an Entire Class of Prediction Models Simultaneously](https://mlsanity.com/paper/1801.01489/) (2018)
- [SCINet: Time Series Modeling and Forecasting with Sample Convolution and Interaction](https://mlsanity.com/paper/2106.09305/) (2021)
- [Recurrent Neural Networks for Time Series Forecasting: Current Status and Future Directions](https://mlsanity.com/paper/1909.00590/) (2019)
- [Less Is More: Fast Multivariate Time Series Forecasting with Light Sampling-oriented MLP Structures](https://mlsanity.com/paper/2207.01186/) (2022)
- [Foundations and Trends in Multimodal Machine Learning: Principles, Challenges, and Open Questions](https://mlsanity.com/paper/2209.03430/) (2022)
- [Time Series Modeling for Heart Rate Prediction: From ARIMA to Transformers](https://mlsanity.com/paper/2406.12199/) (2024)
- [A Review on Methods and Applications in Multimodal Deep Learning](https://mlsanity.com/paper/2202.09195/) (2022)

## Built on by (most cited first, 1 of 1)

- [BlackGoose Rimer: Harnessing RWKV-7 as a Simple yet Superior Replacement for Transformers in Large-Scale Time Series Modeling](https://mlsanity.com/paper/2503.06121/) (2025)

## Abstract (arXiv)

Acute Coronary Syndromes (ACS), including ST-segment elevation myocardial infarctions (STEMI) and non-ST-segment elevation myocardial infarctions (NSTEMI), remain a leading cause of mortality worldwide. Traditional cardiovascular risk scores rely primarily on clinical data, often overlooking environmental influences like air pollution that significantly impact heart health. Moreover, integrating complex time-series environmental data with clinical records is challenging. We introduce TabulaTime, a multimodal deep learning framework that enhances ACS risk prediction by combining clinical risk factors with air pollution data. TabulaTime features three key innovations: First, it integrates time-series air pollution data with clinical tabular data to improve prediction accuracy. Second, its PatchRWKV module automatically extracts complex temporal patterns, overcoming limitations of traditional feature engineering while maintaining linear computational complexity. Third, attention mechanisms enhance interpretability by revealing interactions between clinical and environmental factors. Experimental results show that TabulaTime improves prediction accuracy by over 20% compared to conventional models such as CatBoost, Random Forest, and LightGBM, with air pollution data alone contributing over a 10% improvement. Feature importance analysis identifies critical predictors including previous angina, systolic blood pressure, PM10, and NO2. Overall, TabulaTime bridges clinical and environmental insights, supporting personalized prevention strategies and informing public health policies to mitigate ACS risk.