# M3DA: Benchmark for Unsupervised Domain Adaptation in 3D Medical Image Segmentation

arXiv: https://arxiv.org/abs/2502.17029 · HTML: https://mlsanity.com/paper/2502.17029/

## Key facts

- Cited by 1 papers in the map (data through 14 Oct 2026).
- Builds on 49 of its 80 references that are in the map.
- First posted on arXiv 24 Feb 2025.

## Builds on (most cited first, 30 of 49)

- [Batch Normalization: Accelerating Deep Network Training by Reducing Internal Covariate Shift](https://mlsanity.com/paper/1502.03167/) (2015)
- [Generative Adversarial Networks](https://mlsanity.com/paper/2203.00667/) (2022)
- [Unsupervised Domain Adaptation by Backpropagation](https://mlsanity.com/paper/1409.7495/) (2014)
- [Learning Transferable Features with Deep Adaptation Networks](https://mlsanity.com/paper/1502.02791/) (2015)
- [Adversarial Discriminative Domain Adaptation](https://mlsanity.com/paper/1702.05464/) (2017)
- [A Survey on Deep Learning in Medical Image Analysis](https://mlsanity.com/paper/1702.05747/) (2017)
- [A Comprehensive Survey on Transfer Learning](https://mlsanity.com/paper/1911.02685/) (2019)
- [In Search of Lost Domain Generalization](https://mlsanity.com/paper/2007.01434/) (2020)
- [UNETR: Transformers for 3D Medical Image Segmentation](https://mlsanity.com/paper/2103.10504/) (2021)
- [Swin UNETR: Swin Transformers for Semantic Segmentation of Brain Tumors in MRI Images](https://mlsanity.com/paper/2201.01266/) (2022)
- [Deep Visual Domain Adaptation: A Survey](https://mlsanity.com/paper/1802.03601/) (2018)
- [ADVENT: Adversarial Entropy Minimization for Domain Adaptation in Semantic Segmentation](https://mlsanity.com/paper/1811.12833/) (2018)
- [Deep Domain Confusion: Maximizing for Domain Invariance](https://mlsanity.com/paper/1412.3474/) (2014)
- [Learning to Adapt Structured Output Space for Semantic Segmentation](https://mlsanity.com/paper/1802.10349/) (2018)
- [FDA: Fourier Domain Adaptation for Semantic Segmentation](https://mlsanity.com/paper/2004.05498/) (2020)
- [Return of Frustratingly Easy Domain Adaptation](https://mlsanity.com/paper/1511.05547/) (2015)
- [A Survey of Unsupervised Deep Domain Adaptation](https://mlsanity.com/paper/1812.02849/) (2018)
- [Domain Adaptation for Medical Image Analysis: A Survey](https://mlsanity.com/paper/2102.09508/) (2021)
- [AMOS: A Large-Scale Abdominal Multi-Organ Benchmark for Versatile Medical Image Segmentation](https://mlsanity.com/paper/2206.08023/) (2022)
- [CHAOS Challenge -- Combined (CT-MR) Healthy Abdominal Organ Segmentation](https://mlsanity.com/paper/2001.06535/) (2020)
- [nnU-Net Revisited: A Call for Rigorous Validation in 3D Medical Image Segmentation](https://mlsanity.com/paper/2404.09556/) (2024)
- [CLIP-Driven Universal Model for Organ Segmentation and Tumor Detection](https://mlsanity.com/paper/2301.00785/) (2023)
- [Improved Texture Networks: Maximizing Quality and Diversity in Feed-forward Stylization and Texture Synthesis](https://mlsanity.com/paper/1701.02096/) (2017)
- [MedNeXt: Transformer-driven Scaling of ConvNets for Medical Image Segmentation](https://mlsanity.com/paper/2303.09975/) (2023)
- [Unsupervised domain adaptation in brain lesion segmentation with adversarial networks](https://mlsanity.com/paper/1612.08894/) (2016)
- [Shape-aware Meta-learning for Generalizing Prostate MRI Segmentation to Unseen Domains](https://mlsanity.com/paper/2007.02035/) (2020)
- [Causality-inspired Single-source Domain Generalization for Medical Image Segmentation](https://mlsanity.com/paper/2111.12525/) (2021)
- [Standardized Assessment of Automatic Segmentation of White Matter Hyperintensities and Results of the WMH Segmentation Challenge](https://mlsanity.com/paper/1904.00682/) (2019)
- [Translating and Segmenting Multimodal Medical Volumes with Cycle- and Shape-Consistency Generative Adversarial Network](https://mlsanity.com/paper/1802.09655/) (2018)
- [Unsupervised domain adaptation for medical imaging segmentation with self-ensembling](https://mlsanity.com/paper/1811.06042/) (2018)

## Built on by (most cited first, 1 of 1)

- [How Far from Clinical Deployment? Evaluating the Complete Unsupervised Domain Adaptation Pipeline in Medical Imaging](https://mlsanity.com/paper/2608.12035/) (2026)

## Abstract (arXiv)

Domain shift presents a significant challenge in applying Deep Learning to the segmentation of 3D medical images from sources like Magnetic Resonance Imaging (MRI) and Computed Tomography (CT). Although numerous Domain Adaptation methods have been developed to address this issue, they are often evaluated under impractical data shift scenarios. Specifically, the medical imaging datasets used are often either private, too small for robust training and evaluation, or limited to single or synthetic tasks. To overcome these limitations, we introduce a M3DA /"mEd@/ benchmark comprising four publicly available, multiclass segmentation datasets. We have designed eight domain pairs featuring diverse and practically relevant distribution shifts. These include inter-modality shifts between MRI and CT and intra-modality shifts among various MRI acquisition parameters, different CT radiation doses, and presence/absence of contrast enhancement in images. Within the proposed benchmark, we evaluate more than ten existing domain adaptation methods. Our results show that none of them can consistently close the performance gap between the domains. For instance, the most effective method reduces the performance gap by about 62% across the tasks. This highlights the need for developing novel domain adaptation algorithms to enhance the robustness and scalability of deep learning models in medical imaging. We made our M3DA benchmark publicly available: https://github.com/BorisShirokikh/M3DA.