# AdverX-Ray: Ensuring X-Ray Integrity Through Frequency-Sensitive Adversarial VAEs

arXiv: https://arxiv.org/abs/2502.16610 · HTML: https://mlsanity.com/paper/2502.16610/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 12 of its 19 references that are in the map.
- First posted on arXiv 23 Feb 2025.

## Builds on (most cited first, 12 of 12)

- [Batch Normalization: Accelerating Deep Network Training by Reducing Internal Covariate Shift](https://mlsanity.com/paper/1502.03167/) (2015)
- [Glow: Generative Flow with Invertible 1x1 Convolutions](https://mlsanity.com/paper/1807.03039/) (2018)
- [Generalized Out-of-Distribution Detection: A Survey](https://mlsanity.com/paper/2110.11334/) (2021)
- [Why Normalizing Flows Fail to Detect Out-of-Distribution Data](https://mlsanity.com/paper/2006.08545/) (2020)
- [Denoising diffusion models for out-of-distribution detection](https://mlsanity.com/paper/2211.07740/) (2022)
- [BIMCV COVID-19+: a large annotated dataset of RX and CT images from COVID-19 patients](https://mlsanity.com/paper/2006.01174/) (2020)
- [Batch Normalization Increases Adversarial Vulnerability and Decreases Adversarial Transferability: A Non-Robust Feature Perspective](https://mlsanity.com/paper/2010.03316/) (2020)
- [Removing Batch Normalization Boosts Adversarial Training](https://mlsanity.com/paper/2207.01156/) (2022)
- [Catch Missing Details: Image Reconstruction with Frequency Augmented Variational Autoencoder](https://mlsanity.com/paper/2305.02541/) (2023)
- [Exploring The Effect of High-frequency Components in GANs Training](https://mlsanity.com/paper/2103.11093/) (2021)
- [Exploring Covariate and Concept Shift for Detection and Calibration of Out-of-Distribution Data](https://mlsanity.com/paper/2110.15231/) (2021)
- [AVAE: Adversarial Variational Auto Encoder](https://mlsanity.com/paper/2012.11551/) (2020)

## Abstract (arXiv)

Ensuring the quality and integrity of medical images is crucial for maintaining diagnostic accuracy in deep learning-based Computer-Aided Diagnosis and Computer-Aided Detection (CAD) systems. Covariate shifts are subtle variations in the data distribution caused by different imaging devices or settings and can severely degrade model performance, similar to the effects of adversarial attacks. Therefore, it is vital to have a lightweight and fast method to assess the quality of these images prior to using CAD models. AdverX-Ray addresses this need by serving as an image-quality assessment layer, designed to detect covariate shifts effectively. This Adversarial Variational Autoencoder prioritizes the discriminator's role, using the suboptimal outputs of the generator as negative samples to fine-tune the discriminator's ability to identify high-frequency artifacts. Images generated by adversarial networks often exhibit severe high-frequency artifacts, guiding the discriminator to focus excessively on these components. This makes the discriminator ideal for this approach. Trained on patches from X-ray images of specific machine models, AdverX-Ray can evaluate whether a scan matches the training distribution, or if a scan from the same machine is captured under different settings. Extensive comparisons with various OOD detection methods show that AdverX-Ray significantly outperforms existing techniques, achieving a 96.2% average AUROC using only 64 random patches from an X-ray. Its lightweight and fast architecture makes it suitable for real-time applications, enhancing the reliability of medical imaging systems. The code and pretrained models are publicly available.