# RGAR: Recurrence Generation-augmented Retrieval for Factual-aware Medical Question Answering

arXiv: https://arxiv.org/abs/2502.13361 · HTML: https://mlsanity.com/paper/2502.13361/

## Key facts

- Cited by 5 papers in the map (data through 14 Oct 2026).
- Placed in Medical and biomedical RAG, one of 15 directions in Retrieval-augmented generation.
- Builds on 45 of its 83 references that are in the map.
- First posted on arXiv 19 Feb 2025.

## Placed in

- Retrieval-augmented generation / [Medical and biomedical RAG](https://mlsanity.com/rag/medical-and-biomedical-rag/)

## Builds on (most cited first, 30 of 45)

- [BERT: Pre-training of Deep Bidirectional Transformers for Language Understanding](https://mlsanity.com/paper/1810.04805/) (2018)
- [GPT-4 Technical Report](https://mlsanity.com/paper/2303.08774/) (2023)
- [The Llama 3 Herd of Models](https://mlsanity.com/paper/2407.21783/) (2024)
- [Retrieval-Augmented Generation for Knowledge-Intensive NLP Tasks](https://mlsanity.com/paper/2005.11401/) (2020)
- [Measuring Massive Multitask Language Understanding](https://mlsanity.com/paper/2009.03300/) (2020)
- [Self-Consistency Improves Chain of Thought Reasoning in Language Models](https://mlsanity.com/paper/2203.11171/) (2022)
- [Large Language Models are Zero-Shot Reasoners](https://mlsanity.com/paper/2205.11916/) (2022)
- [SQuAD: 100,000+ Questions for Machine Comprehension of Text](https://mlsanity.com/paper/1606.05250/) (2016)
- [Dense Passage Retrieval for Open-Domain Question Answering](https://mlsanity.com/paper/2004.04906/) (2020)
- [Extracting Training Data from Large Language Models](https://mlsanity.com/paper/2012.07805/) (2020)
- [What Disease does this Patient Have? A Large-scale Open Domain Question Answering Dataset from Medical Exams](https://mlsanity.com/paper/2009.13081/) (2020)
- [PubMedQA: A Dataset for Biomedical Research Question Answering](https://mlsanity.com/paper/1909.06146/) (2019)
- [Llama Guard: LLM-based Input-Output Safeguard for Human-AI Conversations](https://mlsanity.com/paper/2312.06674/) (2023)
- [Large Language Models Can Be Easily Distracted by Irrelevant Context](https://mlsanity.com/paper/2302.00093/) (2023)
- [Compositional Visual Generation with Composable Diffusion Models](https://mlsanity.com/paper/2206.01714/) (2022)
- [Stealing Machine Learning Models via Prediction APIs](https://mlsanity.com/paper/1609.02943/) (2016)
- [GSM-Symbolic: Understanding the Limitations of Mathematical Reasoning in Large Language Models](https://mlsanity.com/paper/2410.05229/) (2024)
- [RAPTOR: Recursive Abstractive Processing for Tree-Organized Retrieval](https://mlsanity.com/paper/2401.18059/) (2024)
- [Adaptive-RAG: Learning to Adapt Retrieval-Augmented Large Language Models through Question Complexity](https://mlsanity.com/paper/2403.14403/) (2024)
- [Search-o1: Agentic Search-Enhanced Large Reasoning Models](https://mlsanity.com/paper/2501.05366/) (2025)
- [Benchmarking Retrieval-Augmented Generation for Medicine](https://mlsanity.com/paper/2402.13178/) (2024)
- [Generate rather than Retrieve: Large Language Models are Strong Context Generators](https://mlsanity.com/paper/2209.10063/) (2022)
- [Generation-Augmented Retrieval for Open-domain Question Answering](https://mlsanity.com/paper/2009.08553/) (2020)
- [MedCPT: Contrastive Pre-trained Transformers with Large-scale PubMed Search Logs for Zero-shot Biomedical Information Retrieval](https://mlsanity.com/paper/2307.00589/) (2023)
- [PullNet: Open Domain Question Answering with Iterative Retrieval on Knowledge Bases and Text](https://mlsanity.com/paper/1904.09537/) (2019)
- [Do Large Language Models Latently Perform Multi-Hop Reasoning?](https://mlsanity.com/paper/2402.16837/) (2024)
- [Stealing Part of a Production Language Model](https://mlsanity.com/paper/2403.06634/) (2024)
- [Enhancing Noise Robustness of Retrieval-Augmented Language Models with Adaptive Adversarial Training](https://mlsanity.com/paper/2405.20978/) (2024)
- [CEHR-BERT: Incorporating temporal information from structured EHR data to improve prediction tasks](https://mlsanity.com/paper/2111.08585/) (2021)
- [Improving Retrieval-Augmented Generation in Medicine with Iterative Follow-up Questions](https://mlsanity.com/paper/2408.00727/) (2024)

## Built on by (most cited first, 5 of 5)

- [MedCoT-RAG: Causal Chain-of-Thought RAG for Medical Question Answering](https://mlsanity.com/paper/2508.15849/) (2025)
- [TARSE: Test-Time Adaptation via Retrieval of Skills and Experience for Reasoning Agents](https://mlsanity.com/paper/2603.01241/) (2026)
- [RAR2: Retrieval-Augmented Medical Reasoning via Thought-Driven Retrieval](https://mlsanity.com/paper/2509.22713/) (2025)
- [MedCoG: Maximizing LLM Inference Density in Medical Reasoning via Meta-Cognitive Regulation](https://mlsanity.com/paper/2602.07905/) (2026)
- [Refine Medical Diagnosis Using Generation Augmented Retrieval and Clinical Practice Guidelines](https://mlsanity.com/paper/2506.21615/) (2025)

## Abstract (arXiv)

Medical question answering requires extensive access to specialized conceptual knowledge. The current paradigm, Retrieval-Augmented Generation (RAG), acquires expertise medical knowledge through large-scale corpus retrieval and uses this knowledge to guide a general-purpose large language model (LLM) for generating answers. However, existing retrieval approaches often overlook the importance of factual knowledge, which limits the relevance of retrieved conceptual knowledge and restricts its applicability in real-world scenarios, such as clinical decision-making based on Electronic Health Records (EHRs). This paper introduces RGAR, a recurrence generation-augmented retrieval framework that retrieves both relevant factual and conceptual knowledge from dual sources (i.e., EHRs and the corpus), allowing them to interact and refine each another. Through extensive evaluation across three factual-aware medical question answering benchmarks, RGAR establishes a new state-of-the-art performance among medical RAG systems. Notably, the Llama-3.1-8B-Instruct model with RGAR surpasses the considerably larger, RAG-enhanced GPT-3.5. Our findings demonstrate the benefit of extracting factual knowledge for retrieval, which consistently yields improved generation quality.