# LLM Agents Making Agent Tools

arXiv: https://arxiv.org/abs/2502.11705 · HTML: https://mlsanity.com/paper/2502.11705/

## Key facts

- Cited by 48 papers in the map (data through 14 Oct 2026).
- Placed in Software engineering coding agents, one of 16 directions in LLM agents and tool use.
- Builds on 31 of its 61 references that are in the map.
- First posted on arXiv 17 Feb 2025.

## Placed in

- LLM agents and tool use / [Software engineering coding agents](https://mlsanity.com/agents/software-engineering-coding-agents/)

## Builds on (most cited first, 30 of 31)

- [Training language models to follow instructions with human feedback](https://mlsanity.com/paper/2203.02155/) (2022)
- [DeepSeekMath: Pushing the Limits of Mathematical Reasoning in Open Language Models](https://mlsanity.com/paper/2402.03300/) (2024)
- [Toolformer: Language Models Can Teach Themselves to Use Tools](https://mlsanity.com/paper/2302.04761/) (2023)
- [SWE-bench: Can Language Models Resolve Real-World GitHub Issues?](https://mlsanity.com/paper/2310.06770/) (2023)
- [LiveCodeBench: Holistic and Contamination Free Evaluation of Large Language Models for Code](https://mlsanity.com/paper/2403.07974/) (2024)
- [Large Language Models Encode Clinical Knowledge](https://mlsanity.com/paper/2212.13138/) (2022)
- [The AI Scientist: Towards Fully Automated Open-Ended Scientific Discovery](https://mlsanity.com/paper/2408.06292/) (2024)
- [OpenHands: An Open Platform for AI Software Developers as Generalist Agents](https://mlsanity.com/paper/2407.16741/) (2024)
- [ChatDev: Communicative Agents for Software Development](https://mlsanity.com/paper/2307.07924/) (2023)
- [ChemCrow: Augmenting large-language models with chemistry tools](https://mlsanity.com/paper/2304.05376/) (2023)
- [Smarter, Better, Faster, Longer: A Modern Bidirectional Encoder for Fast, Memory Efficient, and Long Context Finetuning and Inference](https://mlsanity.com/paper/2412.13663/) (2024)
- [BigCodeBench: Benchmarking Code Generation with Diverse Function Calls and Complex Instructions](https://mlsanity.com/paper/2406.15877/) (2024)
- [Agent Laboratory: Using LLM Agents as Research Assistants](https://mlsanity.com/paper/2501.04227/) (2025)
- [Agentless: Demystifying LLM-based Software Engineering Agents](https://mlsanity.com/paper/2407.01489/) (2024)
- [RepoBench: Benchmarking Repository-Level Code Auto-Completion Systems](https://mlsanity.com/paper/2306.03091/) (2023)
- [Large Language Models as Tool Makers](https://mlsanity.com/paper/2305.17126/) (2023)
- [Agent Hospital: A Simulacrum of Hospital with Evolvable Medical Agents](https://mlsanity.com/paper/2405.02957/) (2024)
- [Virchow2: Scaling Self-Supervised Mixed Magnification Models in Pathology](https://mlsanity.com/paper/2408.00738/) (2024)
- [CRAFT: Customizing LLMs by Creating and Retrieving from Specialized Toolsets](https://mlsanity.com/paper/2309.17428/) (2023)
- [Empowering Biomedical Discovery with AI Agents](https://mlsanity.com/paper/2404.02831/) (2024)
- [On the Planning Abilities of Large Language Models (A Critical Investigation with a Proposed Benchmark)](https://mlsanity.com/paper/2302.06706/) (2023)
- [Phikon-v2, A large and public feature extractor for biomarker prediction](https://mlsanity.com/paper/2409.09173/) (2024)
- [ML-Bench: Evaluating Large Language Models and Agents for Machine Learning Tasks on Repository-Level Code](https://mlsanity.com/paper/2311.09835/) (2023)
- [FlowMap: High-Quality Camera Poses, Intrinsics, and Depth via Gradient Descent](https://mlsanity.com/paper/2404.15259/) (2024)
- [LegalAgentBench: Evaluating LLM Agents in Legal Domain](https://mlsanity.com/paper/2412.17259/) (2024)
- [SUPER: Evaluating Agents on Setting Up and Executing Tasks from Research Repositories](https://mlsanity.com/paper/2409.07440/) (2024)
- [AgileCoder: Dynamic Collaborative Agents for Software Development based on Agile Methodology](https://mlsanity.com/paper/2406.11912/) (2024)
- [AgentMD: Empowering Language Agents for Risk Prediction with Large-Scale Clinical Tool Learning](https://mlsanity.com/paper/2402.13225/) (2024)
- [Automating Exploratory Proteomics Research via Language Models](https://mlsanity.com/paper/2411.03743/) (2024)
- [Autonomous Artificial Intelligence Agents for Clinical Decision Making in Oncology](https://mlsanity.com/paper/2404.04667/) (2024)

## Built on by (most cited first, 30 of 48)

- [Model Context Protocol (MCP): Landscape, Security Threats, and Future Research Directions](https://mlsanity.com/paper/2503.23278/) (2025)
- [APIGen-MT: Agentic Pipeline for Multi-Turn Data Generation via Simulated Agent-Human Interplay](https://mlsanity.com/paper/2504.03601/) (2025)
- [Open Challenges in Multi-Agent Security: Towards Secure Systems of Interacting AI Agents](https://mlsanity.com/paper/2505.02077/) (2025)
- [A Survey of Agentic Reasoning for Large Language Models: Towards Recursively Self-Improving and Collective Agents](https://mlsanity.com/paper/2601.12538/) (2026)
- [Vibe Coding vs. Agentic Coding: Fundamentals and Practical Implications of Agentic AI](https://mlsanity.com/paper/2505.19443/) (2025)
- [AgentOrchestra: Orchestrating Multi-Agent Intelligence with the Tool-Environment-Agent(TEA) Protocol](https://mlsanity.com/paper/2506.12508/) (2025)
- [CASCADE: Cumulative Agentic Skill Creation through Autonomous Development and Evolution](https://mlsanity.com/paper/2512.23880/) (2025)
- [Generative to Agentic AI: Survey, Conceptualization, and Challenges](https://mlsanity.com/paper/2504.18875/) (2025)
- [RingMo-Agent: A Unified Remote Sensing Foundation Model for Multi-Platform and Multi-Modal Reasoning](https://mlsanity.com/paper/2507.20776/) (2025)
- [Uncovering Security Threats and Architecting Defenses in Autonomous Agents: A Case Study of OpenClaw](https://mlsanity.com/paper/2603.12644/) (2026)
- [From Glue-Code to Protocols: A Critical Analysis of A2A and MCP Integration for Scalable Agent Systems](https://mlsanity.com/paper/2505.03864/) (2025)
- [The Evolution of Tool Use in LLM Agents: From Single-Tool Call to Multi-Tool Orchestration](https://mlsanity.com/paper/2603.22862/) (2026)
- [Autonomous Agents for Scientific Discovery: Orchestrating Scientists, Language, Code, and Physics](https://mlsanity.com/paper/2510.09901/) (2025)
- [Code2MCP: Transforming Code Repositories into MCP Services](https://mlsanity.com/paper/2509.05941/) (2025)
- [What Makes a Good LLM Agent for Real-world Penetration Testing?](https://mlsanity.com/paper/2602.17622/) (2026)
- [A Call for Collaborative Intelligence: Why Human-Agent Systems Should Precede AI Autonomy](https://mlsanity.com/paper/2506.09420/) (2025)
- [Uncertainty-Aware Clarification in LLM Agents with Information Gain](https://mlsanity.com/paper/2606.03135/) (2026)
- [LLM-Agent-Controller: A Universal Multi-Agent Large Language Model System as a Control Engineer](https://mlsanity.com/paper/2505.19567/) (2025)
- [Open Agent Specification (Agent Spec): A Unified Representation for AI Agents](https://mlsanity.com/paper/2510.04173/) (2025)
- [Agentic Systems in Radiology: Design, Applications, Evaluation, and Challenges](https://mlsanity.com/paper/2510.09404/) (2025)
- [Deep Tabular Research via Continual Experience-Driven Execution](https://mlsanity.com/paper/2603.09151/) (2026)
- [RADAR: Redundancy-Aware Diffusion for Multi-Agent Communication Structure Generation](https://mlsanity.com/paper/2605.09907/) (2026)
- [Proof-of-Use: Mitigating Tool-Call Hacking in Deep Research Agents](https://mlsanity.com/paper/2510.10931/) (2025)
- [Unifying Dynamic Tool Creation and Cross-Task Experience Sharing through Cognitive Memory Architecture](https://mlsanity.com/paper/2512.11303/) (2025)
- [Experience-Driven Multi-Agent Systems Are Training-free Context-aware Earth Observers](https://mlsanity.com/paper/2602.02559/) (2026)
- [Learning to Rewrite Tool Descriptions for Reliable LLM-Agent Tool Use](https://mlsanity.com/paper/2602.20426/) (2026)
- [FinTrace: Holistic Trajectory-Level Evaluation of LLM Tool Calling for Long-Horizon Financial Tasks](https://mlsanity.com/paper/2604.10015/) (2026)
- [Giving AI Agents Access to Cryptocurrency and Smart Contracts Creates New Vectors of AI Harm](https://mlsanity.com/paper/2507.08249/) (2025)
- [LAMMI-Pathology: A Tool-Centric Bottom-Up LVLM-Agent Framework for Molecularly Informed Medical Intelligence in Pathology](https://mlsanity.com/paper/2602.18773/) (2026)
- [EH-Benchmark Ophthalmic Hallucination Benchmark and Agent-Driven Top-Down Traceable Reasoning Workflow](https://mlsanity.com/paper/2507.22929/) (2025)

## Abstract (arXiv)

Tool use has turned large language models (LLMs) into powerful agents that can perform complex multi-step tasks by dynamically utilising external software components. However, these tools must be implemented in advance by human developers, hindering the applicability of LLM agents in domains demanding large numbers of highly specialised tools, like in life sciences and medicine. Motivated by the growing trend of scientific studies accompanied by public code repositories, we propose ToolMaker, an agentic framework that autonomously transforms papers with code into LLM-compatible tools. Given a GitHub URL and short task description, ToolMaker autonomously installs dependencies and generates code to perform the task, using a closed-loop self-correction mechanism for debugging. To evaluate our approach, we introduce a benchmark comprising 15 complex computational tasks spanning various domains with over 100 unit tests to assess correctness and robustness. Our method correctly implements 80% of the tasks, substantially outperforming current state-of-the-art software engineering agents. ToolMaker therefore is a step towards fully autonomous agent-based scientific workflows. Our code and benchmark are publicly available at https://github.com/KatherLab/ToolMaker.