# ActiveSSF: An Active-Learning-Guided Self-Supervised Framework for Long-Tailed Megakaryocyte Classification

arXiv: https://arxiv.org/abs/2502.08200 · HTML: https://mlsanity.com/paper/2502.08200/

## Key facts

- Cited by 1 papers in the map (data through 14 Oct 2026).
- Builds on 10 of its 17 references that are in the map.
- First posted on arXiv 12 Feb 2025.

## Builds on (most cited first, 10 of 10)

- [An Image is Worth 16x16 Words: Transformers for Image Recognition at Scale](https://mlsanity.com/paper/2010.11929/) (2020)
- [Momentum Contrast for Unsupervised Visual Representation Learning](https://mlsanity.com/paper/1911.05722/) (2019)
- [Masked Autoencoders Are Scalable Vision Learners](https://mlsanity.com/paper/2111.06377/) (2021)
- [Identity Mappings in Deep Residual Networks](https://mlsanity.com/paper/1603.05027/) (2016)
- [An Empirical Study of Training Self-Supervised Vision Transformers](https://mlsanity.com/paper/2104.02057/) (2021)
- [ConvMAE: Masked Convolution Meets Masked Autoencoders](https://mlsanity.com/paper/2205.03892/) (2022)
- [Mixed Autoencoder for Self-supervised Visual Representation Learning](https://mlsanity.com/paper/2303.17152/) (2023)
- [HFGS: 4D Gaussian Splatting with Emphasis on Spatial and Temporal High-Frequency Components for Endoscopic Scene Reconstruction](https://mlsanity.com/paper/2405.17872/) (2024)
- [Ultrasound Nodule Segmentation Using Asymmetric Learning with Simple Clinical Annotation](https://mlsanity.com/paper/2404.14852/) (2024)
- [SAM-Driven Weakly Supervised Nodule Segmentation with Uncertainty-Aware Cross Teaching](https://mlsanity.com/paper/2407.13553/) (2024)

## Built on by (most cited first, 1 of 1)

- [Divide, Conquer and Unite: Hierarchical Style-Recalibrated Prototype Alignment for Federated Medical Segmentation](https://mlsanity.com/paper/2511.10945/) (2025)

## Abstract (arXiv)

Precise classification of megakaryocytes is crucial for diagnosing myelodysplastic syndromes. Although self-supervised learning has shown promise in medical image analysis, its application to classifying megakaryocytes in stained slides faces three main challenges: (1) pervasive background noise that obscures cellular details, (2) a long-tailed distribution that limits data for rare subtypes, and (3) complex morphological variations leading to high intra-class variability. To address these issues, we propose the ActiveSSF framework, which integrates active learning with self-supervised pretraining. Specifically, our approach employs Gaussian filtering combined with K-means clustering and HSV analysis (augmented by clinical prior knowledge) for accurate region-of-interest extraction; an adaptive sample selection mechanism that dynamically adjusts similarity thresholds to mitigate class imbalance; and prototype clustering on labeled samples to overcome morphological complexity. Experimental results on clinical megakaryocyte datasets demonstrate that ActiveSSF not only achieves state-of-the-art performance but also significantly improves recognition accuracy for rare subtypes. Moreover, the integration of these advanced techniques further underscores the practical potential of ActiveSSF in clinical settings.