# Solving Linear-Gaussian Bayesian Inverse Problems with Decoupled Diffusion Sequential Monte Carlo

arXiv: https://arxiv.org/abs/2502.06379 · HTML: https://mlsanity.com/paper/2502.06379/

## Key facts

- Cited by 10 papers in the map (data through 14 Oct 2026).
- Placed in Inverse problems and image restoration, one of 14 directions in Diffusion models.
- Builds on 36 of its 56 references that are in the map.
- First posted on arXiv 10 Feb 2025.

## Placed in

- Diffusion models / [Inverse problems and image restoration](https://mlsanity.com/diffusion/inverse-problems-and-image-restoration/)

## Builds on (most cited first, 30 of 36)

- [Denoising Diffusion Probabilistic Models](https://mlsanity.com/paper/2006.11239/) (2020)
- [U-Net: Convolutional Networks for Biomedical Image Segmentation](https://mlsanity.com/paper/1505.04597/) (2015)
- [High-Resolution Image Synthesis with Latent Diffusion Models](https://mlsanity.com/paper/2112.10752/) (2021)
- [The Unreasonable Effectiveness of Deep Features as a Perceptual Metric](https://mlsanity.com/paper/1801.03924/) (2018)
- [Denoising Diffusion Implicit Models](https://mlsanity.com/paper/2010.02502/) (2020)
- [Score-Based Generative Modeling through Stochastic Differential Equations](https://mlsanity.com/paper/2011.13456/) (2020)
- [Diffusion Models Beat GANs on Image Synthesis](https://mlsanity.com/paper/2105.05233/) (2021)
- [Deep Unsupervised Learning using Nonequilibrium Thermodynamics](https://mlsanity.com/paper/1503.03585/) (2015)
- [Photorealistic Text-to-Image Diffusion Models with Deep Language Understanding](https://mlsanity.com/paper/2205.11487/) (2022)
- [A Style-Based Generator Architecture for Generative Adversarial Networks](https://mlsanity.com/paper/1812.04948/) (2018)
- [Classifier-Free Diffusion Guidance](https://mlsanity.com/paper/2207.12598/) (2022)
- [Elucidating the Design Space of Diffusion-Based Generative Models](https://mlsanity.com/paper/2206.00364/) (2022)
- [Structured Denoising Diffusion Models in Discrete State-Spaces](https://mlsanity.com/paper/2107.03006/) (2021)
- [Diffusion Posterior Sampling for General Noisy Inverse Problems](https://mlsanity.com/paper/2209.14687/) (2022)
- [DiffWave: A Versatile Diffusion Model for Audio Synthesis](https://mlsanity.com/paper/2009.09761/) (2020)
- [Denoising Diffusion Restoration Models](https://mlsanity.com/paper/2201.11793/) (2022)
- [Equivariant Diffusion for Molecule Generation in 3D](https://mlsanity.com/paper/2203.17003/) (2022)
- [WaveGrad: Estimating Gradients for Waveform Generation](https://mlsanity.com/paper/2009.00713/) (2020)
- [GeoDiff: a Geometric Diffusion Model for Molecular Conformation Generation](https://mlsanity.com/paper/2203.02923/) (2022)
- [A Continuous Time Framework for Discrete Denoising Models](https://mlsanity.com/paper/2205.14987/) (2022)
- [DiffDock: Diffusion Steps, Twists, and Turns for Molecular Docking](https://mlsanity.com/paper/2210.01776/) (2022)
- [Diffusion probabilistic modeling of protein backbones in 3D for the motif-scaffolding problem](https://mlsanity.com/paper/2206.04119/) (2022)
- [Practical and Asymptotically Exact Conditional Sampling in Diffusion Models](https://mlsanity.com/paper/2306.17775/) (2023)
- [Continuous diffusion for categorical data](https://mlsanity.com/paper/2211.15089/) (2022)
- [SNIPS: Solving Noisy Inverse Problems Stochastically](https://mlsanity.com/paper/2105.14951/) (2021)
- [Score-based Continuous-time Discrete Diffusion Models](https://mlsanity.com/paper/2211.16750/) (2022)
- [Improving Diffusion Inverse Problem Solving with Decoupled Noise Annealing](https://mlsanity.com/paper/2407.01521/) (2024)
- [Refining Generative Process with Discriminator Guidance in Score-based Diffusion Models](https://mlsanity.com/paper/2211.17091/) (2022)
- [Principled Probabilistic Imaging using Diffusion Models as Plug-and-Play Priors](https://mlsanity.com/paper/2405.18782/) (2024)
- [A Deep and Tractable Density Estimator](https://mlsanity.com/paper/1310.1757/) (2013)

## Built on by (most cited first, 10 of 10)

- [Solving Inverse Problems via Diffusion-Based Priors: An Approximation-Free Ensemble Sampling Approach](https://mlsanity.com/paper/2506.03979/) (2025)
- [ESS-Flow: Training-free guidance of flow-based models as inference in source space](https://mlsanity.com/paper/2510.05849/) (2025)
- [D-Flow SGLD: Source-Space Posterior Sampling for Scientific Inverse Problems with Flow Matching](https://mlsanity.com/paper/2602.21469/) (2026)
- [Particle-Guided Diffusion Models for Partial Differential Equations](https://mlsanity.com/paper/2601.23262/) (2026)
- [Generative diffusion posterior sampling for informative likelihoods](https://mlsanity.com/paper/2506.01083/) (2025)
- [Predictive posterior sampling from non-stationnary Gaussian process priors via Diffusion models with application to climate data](https://mlsanity.com/paper/2505.24556/) (2025)
- [Modelling Gas-Phase Reaction Kinetics with Guided Particle Diffusion Sampling](https://mlsanity.com/paper/2604.16461/) (2026)
- [Backward SDEs-based Diffusion for Physics-Constrained Generation](https://mlsanity.com/paper/2609.15702/) (2026)
- [Interacting particle guidance for sampling reward-tilted generative priors](https://mlsanity.com/paper/2609.37227/) (2026)
- [Getting Your Guidance Weights Right in diffusion and flow-matching posterior sampling](https://mlsanity.com/paper/2610.03503/) (2026)

## Abstract (arXiv)

A recent line of research has exploited pre-trained generative diffusion models as priors for solving Bayesian inverse problems. We contribute to this research direction by designing a sequential Monte Carlo method for linear-Gaussian inverse problems which builds on "decoupled diffusion", where the generative process is designed such that larger updates to the sample are possible. The method is asymptotically exact and we demonstrate the effectiveness of our Decoupled Diffusion Sequential Monte Carlo (DDSMC) algorithm on both synthetic as well as protein and image data. Further, we demonstrate how the approach can be extended to discrete data.