# Cell Nuclei Detection and Classification in Whole Slide Images with Transformers

arXiv: https://arxiv.org/abs/2502.06307 · HTML: https://mlsanity.com/paper/2502.06307/

## Key facts

- Cited by 1 papers in the map (data through 14 Oct 2026).
- Builds on 14 of its 29 references that are in the map.
- First posted on arXiv 10 Feb 2025.

## Builds on (most cited first, 14 of 14)

- [Deep Residual Learning for Image Recognition](https://mlsanity.com/paper/1512.03385/) (2015)
- [An Image is Worth 16x16 Words: Transformers for Image Recognition at Scale](https://mlsanity.com/paper/2010.11929/) (2020)
- [U-Net: Convolutional Networks for Biomedical Image Segmentation](https://mlsanity.com/paper/1505.04597/) (2015)
- [Microsoft COCO: Common Objects in Context](https://mlsanity.com/paper/1405.0312/) (2014)
- [Swin Transformer: Hierarchical Vision Transformer using Shifted Windows](https://mlsanity.com/paper/2103.14030/) (2021)
- [End-to-End Object Detection with Transformers](https://mlsanity.com/paper/2005.12872/) (2020)
- [Mask R-CNN](https://mlsanity.com/paper/1703.06870/) (2017)
- [Deformable DETR: Deformable Transformers for End-to-End Object Detection](https://mlsanity.com/paper/2010.04159/) (2020)
- [HoVer-Net: Simultaneous Segmentation and Classification of Nuclei in Multi-Tissue Histology Images](https://mlsanity.com/paper/1812.06499/) (2018)
- [PanNuke Dataset Extension, Insights and Baselines](https://mlsanity.com/paper/2003.10778/) (2020)
- [Hierarchical Graph Representations in Digital Pathology](https://mlsanity.com/paper/2102.11057/) (2021)
- [Micro-Net: A unified model for segmentation of various objects in microscopy images](https://mlsanity.com/paper/1804.08145/) (2018)
- [Attention-Based Transformers for Instance Segmentation of Cells in Microstructures](https://mlsanity.com/paper/2011.09763/) (2020)
- [Affine-Consistent Transformer for Multi-Class Cell Nuclei Detection](https://mlsanity.com/paper/2310.14154/) (2023)

## Built on by (most cited first, 1 of 1)

- [NuNext: Reframing Nucleus Detection as Next-Point Detection](https://mlsanity.com/paper/2603.07098/) (2026)

## Abstract (arXiv)

Accurate and efficient cell nuclei detection and classification in histopathological Whole Slide Images (WSIs) are pivotal for digital pathology applications. Traditional cell segmentation approaches, while commonly used, are computationally expensive and require extensive post-processing, limiting their practicality for high-throughput clinical settings. In this paper, we propose a paradigm shift from segmentation to detection for extracting cell information from WSIs, introducing CellNuc-DETR as a more effective solution. We evaluate the accuracy performance of CellNuc-DETR on the PanNuke dataset and conduct cross-dataset evaluations on CoNSeP and MoNuSeg to assess robustness and generalization capabilities. Our results demonstrate state-of-the-art performance in both cell nuclei detection and classification tasks. Additionally, we assess the efficiency of CellNuc-DETR on large WSIs, showing that it not only outperforms current methods in accuracy but also significantly reduces inference times. Specifically, CellNuc-DETR is twice as fast as the fastest segmentation-based method, HoVer-NeXt, while achieving substantially higher accuracy. Moreover, it surpasses CellViT in accuracy and is approximately ten times more efficient in inference speed on WSIs. These results establish CellNuc-DETR as a superior approach for cell analysis in digital pathology, combining high accuracy with computational efficiency.