# LEAD: An EEG Foundation Model for Alzheimer's Disease Detection

arXiv: https://arxiv.org/abs/2502.01678 · HTML: https://mlsanity.com/paper/2502.01678/

## Key facts

- Cited by 9 papers in the map (data through 14 Oct 2026).
- Builds on 32 of its 117 references that are in the map.
- First posted on arXiv 2 Feb 2025.

## Builds on (most cited first, 30 of 32)

- [A Simple Framework for Contrastive Learning of Visual Representations](https://mlsanity.com/paper/2002.05709/) (2020)
- [Masked Autoencoders Are Scalable Vision Learners](https://mlsanity.com/paper/2111.06377/) (2021)
- [Bootstrap your own latent: A new approach to self-supervised Learning](https://mlsanity.com/paper/2006.07733/) (2020)
- [wav2vec 2.0: A Framework for Self-Supervised Learning of Speech Representations](https://mlsanity.com/paper/2006.11477/) (2020)
- [A Time Series is Worth 64 Words: Long-term Forecasting with Transformers](https://mlsanity.com/paper/2211.14730/) (2022)
- [Unsupervised Feature Learning via Non-Parametric Instance-level Discrimination](https://mlsanity.com/paper/1805.01978/) (2018)
- [GLU Variants Improve Transformer](https://mlsanity.com/paper/2002.05202/) (2020)
- [An Empirical Evaluation of Generic Convolutional and Recurrent Networks for Sequence Modeling](https://mlsanity.com/paper/1803.01271/) (2018)
- [TimesNet: Temporal 2D-Variation Modeling for General Time Series Analysis](https://mlsanity.com/paper/2210.02186/) (2022)
- [Self-Supervised Learning from Images with a Joint-Embedding Predictive Architecture](https://mlsanity.com/paper/2301.08243/) (2023)
- [iTransformer: Inverted Transformers Are Effective for Time Series Forecasting](https://mlsanity.com/paper/2310.06625/) (2023)
- [EEGNet: A Compact Convolutional Network for EEG-based Brain-Computer Interfaces](https://mlsanity.com/paper/1611.08024/) (2016)
- [Temporal Convolutional Networks for Action Segmentation and Detection](https://mlsanity.com/paper/1611.05267/) (2016)
- [Large Brain Model for Learning Generic Representations with Tremendous EEG Data in BCI](https://mlsanity.com/paper/2405.18765/) (2024)
- [BENDR: using transformers and a contrastive self-supervised learning task to learn from massive amounts of EEG data](https://mlsanity.com/paper/2101.12037/) (2021)
- [CBraMod: A Criss-Cross Brain Foundation Model for EEG Decoding](https://mlsanity.com/paper/2412.07236/) (2024)
- [Large-scale Training of Foundation Models for Wearable Biosignals](https://mlsanity.com/paper/2312.05409/) (2023)
- [NeuroLM: A Universal Multi-task Foundation Model for Bridging the Gap between Language and EEG Signals](https://mlsanity.com/paper/2409.00101/) (2024)
- [Neuro-GPT: Towards A Foundation Model for EEG](https://mlsanity.com/paper/2311.03764/) (2023)
- [Contrast Everything: A Hierarchical Contrastive Framework for Medical Time-Series](https://mlsanity.com/paper/2310.14017/) (2023)
- [Medformer: A Multi-Granularity Patching Transformer for Medical Time-Series Classification](https://mlsanity.com/paper/2405.19363/) (2024)
- [EEG2Rep: Enhancing Self-supervised EEG Representation Through Informative Masked Inputs](https://mlsanity.com/paper/2402.17772/) (2024)
- [ICLabel: An automated electroencephalographic independent component classifier, dataset, and website](https://mlsanity.com/paper/1901.07915/) (2019)
- [Brant-X: A Unified Physiological Signal Alignment Framework](https://mlsanity.com/paper/2409.00122/) (2024)
- [EEG-Inception: An Accurate and Robust End-to-End Neural Network for EEG-based Motor Imagery Classification](https://mlsanity.com/paper/2101.10932/) (2021)
- [Neuro-BERT: Rethinking Masked Autoencoding for Self-supervised Neurological Pretraining](https://mlsanity.com/paper/2204.12440/) (2022)
- [Adaptive Gated Graph Convolutional Network for Explainable Diagnosis of Alzheimer's Disease using EEG Data](https://mlsanity.com/paper/2304.05874/) (2023)
- [Eeg2vec: Self-Supervised Electroencephalographic Representation Learning](https://mlsanity.com/paper/2305.13957/) (2023)
- [EEG functional connectivity and deep learning for automatic diagnosis of brain disorders: Alzheimer's disease and schizophrenia](https://mlsanity.com/paper/2110.06140/) (2021)
- [What Causes Performance Degradation in Cross-Subject EEG Classification?](https://mlsanity.com/paper/2410.03057/) (2024)

## Built on by (most cited first, 9 of 9)

- [EEG Foundation Challenge: From Cross-Task to Cross-Subject EEG Decoding](https://mlsanity.com/paper/2506.19141/) (2025)
- [Foundation Models for Cross-Domain EEG Analysis Application: A Survey](https://mlsanity.com/paper/2508.15716/) (2025)
- [Variational Mixture of Graph Neural Experts for Alzheimer's Disease Recognition across Frequency Bands in EEG Brain Networks](https://mlsanity.com/paper/2510.11917/) (2025)
- [LERD: Latent Event-Relational Dynamics for Neurodegenerative Classification](https://mlsanity.com/paper/2602.18195/) (2026)
- [SpecMoE: Spectral Mixture-of-Experts Foundation Model for Cross-Species EEG Decoding](https://mlsanity.com/paper/2603.16739/) (2026)
- [Channel-Imposed Fusion: A Simple yet Effective Method for Medical Time Series Classification](https://mlsanity.com/paper/2506.00337/) (2025)
- [A Systematic Evaluation of Self-Supervised Learning for Label-Efficient Sleep Staging with Wearable EEG](https://mlsanity.com/paper/2510.07960/) (2025)
- [Technological Advances in Detecting and Managing Cognitive Impairment in Older Adults: Trends, Challenges, and Future Directions](https://mlsanity.com/paper/2607.28687/) (2026)
- [Benchmarking EEG Foundation Models at Scale: Lessons from 20,000 Evaluations](https://mlsanity.com/paper/2609.32743/) (2026)

## Abstract (arXiv)

Electroencephalography (EEG) provides a non-invasive, highly accessible, and cost-effective approach for detecting Alzheimer's disease (AD). However, existing methods, whether based on handcrafted feature engineering or standard deep learning, face three major challenges: 1) the lack of large-scale EEG-based AD datasets for robust representation learning and evaluation; 2) limited cross-subject generalizability; and 3) difficulty in adapting to highly heterogeneous data. To address these challenges, we curate the world's largest EEG-AD corpus to date, comprising 2,238 subjects. Leveraging this unique resource, we propose LEAD, the first foundation model for EEG-based AD detection. Specifically, we design a gated temporal-spatial Transformer that can adapt to EEG recordings with diverse lengths, channel configurations, and sampling rates. In addition, we introduce a subject-regularized training strategy to enhance end-to-end subject-level detection. We further employ medical contrastive learning to pre-train on 13 datasets, including 4 AD datasets and 9 non-AD neurological disorder datasets, and fine-tune/test the model on the other 5 AD datasets. LEAD achieves the best average ranking across all 20 evaluations on 5 downstream datasets, substantially outperforming existing approaches, including state-of-the-art (SOTA) EEG foundation models. These results strongly demonstrate the effectiveness of our proposed method and significant progress for EEG-based AD detection. Source code: https://github.com/DL4mHealth/LEAD