# VisTA: Vision-Text Alignment Model with Contrastive Learning using Multimodal Data for Evidence-Driven, Reliable, and Explainable Alzheimer's Disease Diagnosis

arXiv: https://arxiv.org/abs/2502.01535 · HTML: https://mlsanity.com/paper/2502.01535/

## Key facts

- Cited by 1 papers in the map (data through 14 Oct 2026).
- Builds on 14 of its 61 references that are in the map.
- First posted on arXiv 3 Feb 2025.

## Builds on (most cited first, 14 of 14)

- [A Simple Framework for Contrastive Learning of Visual Representations](https://mlsanity.com/paper/2002.05709/) (2020)
- [Momentum Contrast for Unsupervised Visual Representation Learning](https://mlsanity.com/paper/1911.05722/) (2019)
- [A Unified Approach to Interpreting Model Predictions](https://mlsanity.com/paper/1705.07874/) (2017)
- [Explainable Artificial Intelligence (XAI): Concepts, Taxonomies, Opportunities and Challenges toward Responsible AI](https://mlsanity.com/paper/1910.10045/) (2019)
- [Contrastive Learning of Medical Visual Representations from Paired Images and Text](https://mlsanity.com/paper/2010.00747/) (2020)
- [MedCLIP: Contrastive Learning from Unpaired Medical Images and Text](https://mlsanity.com/paper/2210.10163/) (2022)
- [A Survey on Explainable Artificial Intelligence (XAI): Towards Medical XAI](https://mlsanity.com/paper/1907.07374/) (2019)
- [Big Self-Supervised Models Advance Medical Image Classification](https://mlsanity.com/paper/2101.05224/) (2021)
- [Contrastive learning of global and local features for medical image segmentation with limited annotations](https://mlsanity.com/paper/2006.10511/) (2020)
- [Interpretable Machine Learning -- A Brief History, State-of-the-Art and Challenges](https://mlsanity.com/paper/2010.09337/) (2020)
- [Integrated multimodal artificial intelligence framework for healthcare applications](https://mlsanity.com/paper/2202.12998/) (2022)
- [BayLIME: Bayesian Local Interpretable Model-Agnostic Explanations](https://mlsanity.com/paper/2012.03058/) (2020)
- [Attention-based Saliency Maps Improve Interpretability of Pneumothorax Classification](https://mlsanity.com/paper/2303.01871/) (2023)
- [SCEHR: Supervised Contrastive Learning for Clinical Risk Prediction using Electronic Health Records](https://mlsanity.com/paper/2110.04943/) (2021)

## Built on by (most cited first, 1 of 1)

- [REMEMBER: Retrieval-based Explainable Multimodal Evidence-guided Modeling for Brain Evaluation and Reasoning in Zero- and Few-shot Neurodegenerative Diagnosis](https://mlsanity.com/paper/2504.09354/) (2025)

## Abstract (arXiv)

Objective: Assessing Alzheimer's disease (AD) using high-dimensional radiology images is clinically important but challenging. Although Artificial Intelligence (AI) has advanced AD diagnosis, it remains unclear how to design AI models embracing predictability and explainability. Here, we propose VisTA, a multimodal language-vision model assisted by contrastive learning, to optimize disease prediction and evidence-based, interpretable explanations for clinical decision-making. Methods: We developed VisTA (Vision-Text Alignment Model) for AD diagnosis. Architecturally, we built VisTA from BiomedCLIP and fine-tuned it using contrastive learning to align images with verified abnormalities and their descriptions. To train VisTA, we used a constructed reference dataset containing images, abnormality types, and descriptions verified by medical experts. VisTA produces four outputs: predicted abnormality type, similarity to reference cases, evidence-driven explanation, and final AD diagnoses. To illustrate VisTA's efficacy, we reported accuracy metrics for abnormality retrieval and dementia prediction. To demonstrate VisTA's explainability, we compared its explanations with human experts' explanations. Results: Compared to 15 million images used for baseline pretraining, VisTA only used 170 samples for fine-tuning and obtained significant improvement in abnormality retrieval and dementia prediction. For abnormality retrieval, VisTA reached 74% accuracy and an AUC of 0.87 (26% and 0.74, respectively, from baseline models). For dementia prediction, VisTA achieved 88% accuracy and an AUC of 0.82 (30% and 0.57, respectively, from baseline models). The generated explanations agreed strongly with human experts' and provided insights into the diagnostic process. Taken together, VisTA optimize prediction, clinical reasoning, and explanation.