# Parameter Efficient Fine-Tuning of Segment Anything Model for Biomedical Imaging

arXiv: https://arxiv.org/abs/2502.00418 · HTML: https://mlsanity.com/paper/2502.00418/

## Key facts

- Cited by 1 papers in the map (data through 14 Oct 2026).
- Builds on 23 of its 46 references that are in the map.
- First posted on arXiv 1 Feb 2025.

## Builds on (most cited first, 23 of 23)

- [BERT: Pre-training of Deep Bidirectional Transformers for Language Understanding](https://mlsanity.com/paper/1810.04805/) (2018)
- [Language Models are Few-Shot Learners](https://mlsanity.com/paper/2005.14165/) (2020)
- [An Image is Worth 16x16 Words: Transformers for Image Recognition at Scale](https://mlsanity.com/paper/2010.11929/) (2020)
- [LoRA: Low-Rank Adaptation of Large Language Models](https://mlsanity.com/paper/2106.09685/) (2021)
- [Segment Anything](https://mlsanity.com/paper/2304.02643/) (2023)
- [QLoRA: Efficient Finetuning of Quantized LLMs](https://mlsanity.com/paper/2305.14314/) (2023)
- [SAM 2: Segment Anything in Images and Videos](https://mlsanity.com/paper/2408.00714/) (2024)
- [UNETR: Transformers for 3D Medical Image Segmentation](https://mlsanity.com/paper/2103.10504/) (2021)
- [AdaptFormer: Adapting Vision Transformers for Scalable Visual Recognition](https://mlsanity.com/paper/2205.13535/) (2022)
- [TotalSegmentator: robust segmentation of 104 anatomical structures in CT images](https://mlsanity.com/paper/2208.05868/) (2022)
- [Scaling & Shifting Your Features: A New Baseline for Efficient Model Tuning](https://mlsanity.com/paper/2210.08823/) (2022)
- [Customized Segment Anything Model for Medical Image Segmentation](https://mlsanity.com/paper/2304.13785/) (2023)
- [Parameter-Efficient Fine-Tuning Methods for Pretrained Language Models: A Critical Review and Assessment](https://mlsanity.com/paper/2312.12148/) (2023)
- [Cell Detection with Star-convex Polygons](https://mlsanity.com/paper/1806.03535/) (2018)
- [FacT: Factor-Tuning for Lightweight Adaptation on Vision Transformer](https://mlsanity.com/paper/2212.03145/) (2022)
- [BiomedParse: a biomedical foundation model for image parsing of everything everywhere all at once](https://mlsanity.com/paper/2405.12971/) (2024)
- [MA-SAM: Modality-agnostic SAM Adaptation for 3D Medical Image Segmentation](https://mlsanity.com/paper/2309.08842/) (2023)
- [Parameter-Efficient Fine-Tuning for Medical Image Analysis: The Missed Opportunity](https://mlsanity.com/paper/2305.08252/) (2023)
- [Empirical Analysis of the Strengths and Weaknesses of PEFT Techniques for LLMs](https://mlsanity.com/paper/2304.14999/) (2023)
- [Strong Baselines for Parameter Efficient Few-Shot Fine-tuning](https://mlsanity.com/paper/2304.01917/) (2023)
- [How to build the best medical image segmentation algorithm using foundation models: a comprehensive empirical study with Segment Anything Model](https://mlsanity.com/paper/2404.09957/) (2024)
- [Parameter Efficient Fine Tuning: A Comprehensive Analysis Across Applications](https://mlsanity.com/paper/2404.13506/) (2024)
- [CellSeg1: Robust Cell Segmentation with One Training Image](https://mlsanity.com/paper/2412.01410/) (2024)

## Built on by (most cited first, 1 of 1)

- [Are Vision Foundation Models Foundational for Electron Microscopy Image Segmentation?](https://mlsanity.com/paper/2602.08505/) (2026)

## Abstract (arXiv)

Segmentation is an important analysis task for biomedical images, enabling the study of individual organelles, cells or organs. Deep learning has massively improved segmentation methods, but challenges remain in generalization to new conditions, requiring costly data annotation. Vision foundation models, such as Segment Anything Model (SAM), address this issue through improved generalization. However, these models still require finetuning on annotated data, although with less annotations, to achieve optimal results for new conditions. As a downside, they require more computational resources. This makes parameter-efficient finetuning (PEFT) relevant. We contribute the first comprehensive study of PEFT for SAM applied to biomedical images. We find that the placement of PEFT layers is more important for efficiency than the type of layer for vision transformers and we provide a recipe for resource-efficient finetuning. Our code is publicly available at https://github.com/computational-cell-analytics/peft-sam.