# Bridging Contrastive Learning and Domain Adaptation: Theoretical Perspective and Practical Application

arXiv: https://arxiv.org/abs/2502.00052 · HTML: https://mlsanity.com/paper/2502.00052/

## Key facts

- Cited by 1 papers in the map (data through 14 Oct 2026).
- Builds on 29 of its 53 references that are in the map.
- First posted on arXiv 28 Jan 2025.

## Builds on (most cited first, 29 of 29)

- [Learning Transferable Visual Models From Natural Language Supervision](https://mlsanity.com/paper/2103.00020/) (2021)
- [High-Resolution Image Synthesis with Latent Diffusion Models](https://mlsanity.com/paper/2112.10752/) (2021)
- [A Simple Framework for Contrastive Learning of Visual Representations](https://mlsanity.com/paper/2002.05709/) (2020)
- [Representation Learning with Contrastive Predictive Coding](https://mlsanity.com/paper/1807.03748/) (2018)
- [Momentum Contrast for Unsupervised Visual Representation Learning](https://mlsanity.com/paper/1911.05722/) (2019)
- [Densely Connected Convolutional Networks](https://mlsanity.com/paper/1608.06993/) (2016)
- [Scaling Up Visual and Vision-Language Representation Learning With Noisy Text Supervision](https://mlsanity.com/paper/2102.05918/) (2021)
- [Domain-Adversarial Training of Neural Networks](https://mlsanity.com/paper/1505.07818/) (2015)
- [Supervised Contrastive Learning](https://mlsanity.com/paper/2004.11362/) (2020)
- [SimCSE: Simple Contrastive Learning of Sentence Embeddings](https://mlsanity.com/paper/2104.08821/) (2021)
- [Adversarial Discriminative Domain Adaptation](https://mlsanity.com/paper/1702.05464/) (2017)
- [Deep Transfer Learning with Joint Adaptation Networks](https://mlsanity.com/paper/1605.06636/) (2016)
- [Contrastive learning of global and local features for medical image segmentation with limited annotations](https://mlsanity.com/paper/2006.10511/) (2020)
- [A Brief Review of Domain Adaptation](https://mlsanity.com/paper/2010.03978/) (2020)
- [Sliced Wasserstein Discrepancy for Unsupervised Domain Adaptation](https://mlsanity.com/paper/1903.04064/) (2019)
- [DeepJDOT: Deep Joint Distribution Optimal Transport for Unsupervised Domain Adaptation](https://mlsanity.com/paper/1803.10081/) (2018)
- [A review of domain adaptation without target labels](https://mlsanity.com/paper/1901.05335/) (2019)
- [Selective-Supervised Contrastive Learning with Noisy Labels](https://mlsanity.com/paper/2203.04181/) (2022)
- [Deep Neural Networks Improve Radiologists' Performance in Breast Cancer Screening](https://mlsanity.com/paper/1903.08297/) (2019)
- [End-to-end Training for Whole Image Breast Cancer Diagnosis using An All Convolutional Design](https://mlsanity.com/paper/1711.05775/) (2017)
- [Self-Supervised Learning with Kernel Dependence Maximization](https://mlsanity.com/paper/2106.08320/) (2021)
- [CLDA: Contrastive Learning for Semi-Supervised Domain Adaptation](https://mlsanity.com/paper/2107.00085/) (2021)
- [Contrastive Domain Adaptation](https://mlsanity.com/paper/2103.15566/) (2021)
- [Federated Contrastive Learning for Decentralized Unlabeled Medical Images](https://mlsanity.com/paper/2109.07504/) (2021)
- [Federated Contrastive Learning for Volumetric Medical Image Segmentation](https://mlsanity.com/paper/2204.10983/) (2022)
- [Breast Cancer Diagnosis in Two-View Mammography Using End-to-End Trained EfficientNet-Based Convolutional Network](https://mlsanity.com/paper/2110.01606/) (2021)
- [Domain generalization in deep learning-based mass detection in mammography: A large-scale multi-center study](https://mlsanity.com/paper/2201.11620/) (2022)
- [Optimizing CLIP Models for Image Retrieval with Maintained Joint-Embedding Alignment](https://mlsanity.com/paper/2409.01936/) (2024)
- [A Unified Joint Maximum Mean Discrepancy for Domain Adaptation](https://mlsanity.com/paper/2101.09979/) (2021)

## Built on by (most cited first, 1 of 1)

- [ST-DAI: Single-shot 2.5D Spatial Transcriptomics with Intra-Sample Domain Adaptive Imputation for Cost-efficient 3D Reconstruction](https://mlsanity.com/paper/2507.21516/) (2025)

## Abstract (arXiv)

This work studies the relationship between Contrastive Learning and Domain Adaptation from a theoretical perspective. The two standard contrastive losses, NT-Xent loss (Self-supervised) and Supervised Contrastive loss, are related to the Class-wise Mean Maximum Discrepancy (CMMD), a dissimilarity measure widely used for Domain Adaptation. Our work shows that minimizing the contrastive losses decreases the CMMD and simultaneously improves class-separability, laying the theoretical groundwork for the use of Contrastive Learning in the context of Domain Adaptation. Due to the relevance of Domain Adaptation in medical imaging, we focused the experiments on mammography images. Extensive experiments on three mammography datasets - synthetic patches, clinical (real) patches, and clinical (real) images - show improved Domain Adaptation, class-separability, and classification performance, when minimizing the Supervised Contrastive loss.