# Towards Physiologically Sensible Predictions via the Rule-based Reinforcement Learning Layer

arXiv: https://arxiv.org/abs/2501.19055 · HTML: https://mlsanity.com/paper/2501.19055/

## Key facts

- Cited by 1 papers in the map (data through 14 Oct 2026).
- Placed in RL for clinical treatment and surgery, one of 15 directions in Deep reinforcement learning methods.
- First posted on arXiv 31 Jan 2025.

## Placed in

- Deep reinforcement learning methods / [RL for clinical treatment and surgery](https://mlsanity.com/deeprl/rl-for-clinical-treatment-and-surgery/)

## Built on by (most cited first, 1 of 1)

- [Beyond Prediction: Reinforcement Learning as the Defining Leap in Healthcare AI](https://mlsanity.com/paper/2508.21101/) (2025)

## Abstract (arXiv)

This paper adds to the growing literature of reinforcement learning (RL) for healthcare by proposing a novel paradigm: augmenting any predictor with Rule-based RL Layer (RRLL) that corrects the model's physiologically impossible predictions. Specifically, RRLL takes as input states predicted labels and outputs corrected labels as actions. The reward of the state-action pair is evaluated by a set of general rules. RRLL is efficient, general and lightweight: it does not require heavy expert knowledge like prior work but only a set of impossible transitions. This set is much smaller than all possible transitions; yet it can effectively reduce physiologically impossible mistakes made by the state-of-the-art predictor models. We verify the utility of RRLL on a variety of important healthcare classification problems and observe significant improvements using the same setup, with only the domain-specific set of impossibility changed. In-depth analysis shows that RRLL indeed improves accuracy by effectively reducing the presence of physiologically impossible predictions.