# Exploring Large Protein Language Models in Constrained Evaluation Scenarios within the FLIP Benchmark

arXiv: https://arxiv.org/abs/2501.18223 · HTML: https://mlsanity.com/paper/2501.18223/

## Key facts

- Cited by 1 papers in the map (data through 14 Oct 2026).
- First posted on arXiv 30 Jan 2025.

## Built on by (most cited first, 1 of 1)

- [EpiBench: Can LLMs Understand Epitopes for Antibody Drug Discovery?](https://mlsanity.com/paper/2608.06022/) (2026)

## Abstract (arXiv)

In this study, we expand upon the FLIP benchmark-designed for evaluating protein fitness prediction models in small, specialized prediction tasks-by assessing the performance of state-of-the-art large protein language models, including ESM-2 and SaProt on the FLIP dataset. Unlike larger, more diverse benchmarks such as ProteinGym, which cover a broad spectrum of tasks, FLIP focuses on constrained settings where data availability is limited. This makes it an ideal framework to evaluate model performance in scenarios with scarce task-specific data. We investigate whether recent advances in protein language models lead to significant improvements in such settings. Our findings provide valuable insights into the performance of large-scale models in specialized protein prediction tasks.