# Panacea: Mitigating Harmful Fine-tuning for Large Language Models via Post-fine-tuning Perturbation

arXiv: https://arxiv.org/abs/2501.18100 · HTML: https://mlsanity.com/paper/2501.18100/

## Key facts

- Cited by 20 papers in the map (data through 14 Oct 2026).
- Builds on 65 of its 146 references that are in the map.
- First posted on arXiv 30 Jan 2025.

## Builds on (most cited first, 30 of 65)

- [Training language models to follow instructions with human feedback](https://mlsanity.com/paper/2203.02155/) (2022)
- [LoRA: Low-Rank Adaptation of Large Language Models](https://mlsanity.com/paper/2106.09685/) (2021)
- [Llama 2: Open Foundation and Fine-Tuned Chat Models](https://mlsanity.com/paper/2307.09288/) (2023)
- [Training Verifiers to Solve Math Word Problems](https://mlsanity.com/paper/2110.14168/) (2021)
- [Direct Preference Optimization: Your Language Model is Secretly a Reward Model](https://mlsanity.com/paper/2305.18290/) (2023)
- [Training a Helpful and Harmless Assistant with Reinforcement Learning from Human Feedback](https://mlsanity.com/paper/2204.05862/) (2022)
- [Universal and Transferable Adversarial Attacks on Aligned Language Models](https://mlsanity.com/paper/2307.15043/) (2023)
- [Character-level Convolutional Networks for Text Classification](https://mlsanity.com/paper/1509.01626/) (2015)
- [Qwen2 Technical Report](https://mlsanity.com/paper/2407.10671/) (2024)
- [Gemma 2: Improving Open Language Models at a Practical Size](https://mlsanity.com/paper/2408.00118/) (2024)
- [Decoupled Weight Decay Regularization](https://mlsanity.com/paper/1711.05101/) (2017)
- [Fine-tuning Aligned Language Models Compromises Safety, Even When Users Do Not Intend To!](https://mlsanity.com/paper/2310.03693/) (2023)
- [BeaverTails: Towards Improved Safety Alignment of LLM via a Human-Preference Dataset](https://mlsanity.com/paper/2307.04657/) (2023)
- [RAFT: Reward rAnked FineTuning for Generative Foundation Model Alignment](https://mlsanity.com/paper/2304.06767/) (2023)
- [Safety Alignment Should Be Made More Than Just a Few Tokens Deep](https://mlsanity.com/paper/2406.05946/) (2024)
- [RRHF: Rank Responses to Align Language Models with Human Feedback without tears](https://mlsanity.com/paper/2304.05302/) (2023)
- [Safety-Tuned LLaMAs: Lessons From Improving the Safety of Large Language Models that Follow Instructions](https://mlsanity.com/paper/2309.07875/) (2023)
- [Shadow Alignment: The Ease of Subverting Safely-Aligned Language Models](https://mlsanity.com/paper/2310.02949/) (2023)
- [SORRY-Bench: Systematically Evaluating Large Language Model Safety Refusal](https://mlsanity.com/paper/2406.14598/) (2024)
- [Assessing the Brittleness of Safety Alignment via Pruning and Low-Rank Modifications](https://mlsanity.com/paper/2402.05162/) (2024)
- [LoRA Fine-tuning Efficiently Undoes Safety Training in Llama 2-Chat 70B](https://mlsanity.com/paper/2310.20624/) (2023)
- [Latent Adversarial Training Improves Robustness to Persistent Harmful Behaviors in LLMs](https://mlsanity.com/paper/2407.15549/) (2024)
- [Removing RLHF Protections in GPT-4 via Fine-Tuning](https://mlsanity.com/paper/2311.05553/) (2023)
- [Safety Fine-Tuning at (Almost) No Cost: A Baseline for Vision Large Language Models](https://mlsanity.com/paper/2402.02207/) (2024)
- [Chain of Hindsight Aligns Language Models with Feedback](https://mlsanity.com/paper/2302.02676/) (2023)
- [Tamper-Resistant Safeguards for Open-Weight LLMs](https://mlsanity.com/paper/2408.00761/) (2024)
- [Safety Layers in Aligned Large Language Models: The Key to LLM Security](https://mlsanity.com/paper/2408.17003/) (2024)
- [Safe LoRA: the Silver Lining of Reducing Safety Risks when Fine-tuning Large Language Models](https://mlsanity.com/paper/2405.16833/) (2024)
- [What is in Your Safe Data? Identifying Benign Data that Breaks Safety](https://mlsanity.com/paper/2404.01099/) (2024)
- [Vaccine: Perturbation-aware Alignment for Large Language Models against Harmful Fine-tuning Attack](https://mlsanity.com/paper/2402.01109/) (2024)

## Built on by (most cited first, 20 of 20)

- [A Comprehensive Survey in LLM(-Agent) Full Stack Safety: Data, Training and Deployment](https://mlsanity.com/paper/2504.15585/) (2025)
- [Safety at Scale: A Comprehensive Survey of Large Model and Agent Safety](https://mlsanity.com/paper/2502.05206/) (2025)
- [Backdoor Cleaning without External Guidance in MLLM Fine-tuning](https://mlsanity.com/paper/2505.16916/) (2025)
- [Benign Samples Matter! Fine-tuning On Outlier Benign Samples Severely Breaks Safety](https://mlsanity.com/paper/2505.06843/) (2025)
- [Adaptive Defense against Harmful Fine-Tuning for Large Language Models via Bayesian Data Scheduler](https://mlsanity.com/paper/2510.27172/) (2025)
- [CTRAP: Embedding Collapse Trap to Safeguard Large Language Models from Harmful Fine-Tuning](https://mlsanity.com/paper/2505.16559/) (2025)
- [Shape it Up! Restoring LLM Safety during Finetuning](https://mlsanity.com/paper/2505.17196/) (2025)
- [Towards Resilient Safety-driven Unlearning for Diffusion Models against Downstream Fine-tuning](https://mlsanity.com/paper/2507.16302/) (2025)
- [Reshaping Representation Space to Balance the Safety and Over-rejection in Large Audio Language Models](https://mlsanity.com/paper/2505.19670/) (2025)
- [Safety Subspaces are Not Linearly Distinct: A Fine-Tuning Case Study](https://mlsanity.com/paper/2505.14185/) (2025)
- [Pharmacist: Safety Alignment Data Curation for Large Language Models against Harmful Fine-tuning](https://mlsanity.com/paper/2510.10085/) (2025)
- [Antibody: Strengthening Defense Against Harmful Fine-Tuning for Large Language Models via Attenuating Harmful Gradient Influence](https://mlsanity.com/paper/2603.00498/) (2026)
- [Q-realign: Piggybacking Realignment on Quantization for Safe and Efficient LLM Deployment](https://mlsanity.com/paper/2601.08089/) (2026)
- [Surgery: Mitigating Harmful Fine-Tuning for Large Language Models via Attention Sink](https://mlsanity.com/paper/2602.05228/) (2026)
- [Preventing Safety Drift in Large Language Models via Coupled Weight and Activation Constraints](https://mlsanity.com/paper/2604.12384/) (2026)
- [Safety-Aligned Weights Are Not Enough: Refusal-Teacher-Guided Finetuning Enhances Safety and Downstream Performance under Harmful Finetuning Attacks](https://mlsanity.com/paper/2506.07356/) (2025)
- [Safeguarding LLM Fine-tuning via Push-Pull Distributional Alignment](https://mlsanity.com/paper/2601.07200/) (2026)
- [Safety Anchor: Defending Harmful Fine-tuning via Geometric Bottlenecks](https://mlsanity.com/paper/2605.05995/) (2026)
- [Jailbreak to Protect: Buffering and Reinforcing via Temporary Jailbreaking for Safe Fine-Tuning in Large Language Models](https://mlsanity.com/paper/2605.24550/) (2026)
- [The Safeguard Worked. Is the LLM System Safer?](https://mlsanity.com/paper/2609.00519/) (2026)

## Abstract (arXiv)

Harmful fine-tuning attack introduces significant security risks to the fine-tuning services. Main-stream defenses aim to vaccinate the model such that the later harmful fine-tuning attack is less effective. However, our evaluation results show that such defenses are fragile--with a few fine-tuning steps, the model still can learn the harmful knowledge. To this end, we do further experiment and find that an embarrassingly simple solution--adding purely random perturbations to the fine-tuned model, can recover the model from harmful behaviors, though it leads to a degradation in the model's fine-tuning performance. To address the degradation of fine-tuning performance, we further propose Panacea, which optimizes an adaptive perturbation that will be applied to the model after fine-tuning. Panacea maintains model's safety alignment performance without compromising downstream fine-tuning performance. Comprehensive experiments are conducted on different harmful ratios, fine-tuning tasks and mainstream LLMs, where the average harmful scores are reduced by up-to 21.2%, while maintaining fine-tuning performance. As a by-product, we analyze the adaptive perturbation and show that different layers in various LLMs have distinct safety affinity, which coincide with finding from several previous study. Source code available at https://github.com/w-yibo/Panacea.